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Flux balance analysis (FBA) is a mathemati … Flux balance analysis (FBA) is a mathematical method for simulating metabolism in genome-scale reconstructions of metabolic networks. In comparison to traditional methods of modeling, FBA is less intensive in terms of the input data required for constructing the model. Simulations performed using FBA are computationally inexpensive and can calculate steady-state metabolic fluxes for large models (over 2000 reactions) in a few seconds on modern personal computers. The related method of metabolic pathway analysis seeks to find and list all possible pathways between metabolites. FBA finds applications in bioprocess engineering to systematically identify modifications to the metabolic networks of microbes used in fermentation processes that improve product yields of industrially important chemicals such as ethanol and succinic acid. It has also been used for the identification of putative drug targets in cancer and pathogens, rational design of culture media, and host–pathogen interactions. The results of FBA can be visualized using flux maps similar to the image on the right, which illustrates the steady-state fluxes carried by reactions in glycolysis. The thickness of the arrows is proportional to the flux through the reaction. FBA formalizes the system of equations describing the concentration changes in a metabolic network as the dot product of a matrix of the stoichiometric coefficients (the stoichiometric matrix S) and the vector v of the unsolved fluxes. The right-hand side of the dot product is a vector of zeros representing the system at steady state. Linear programming is then used to calculate a solution of fluxes corresponding to the steady state. fluxes corresponding to the steady state.
, El análisis de balance de flujo (ABF) es u … El análisis de balance de flujo (ABF) es un método matemático para analizar el metabolismo en un sistema biológico. A diferencia de otros métodos de modelaje, no requiere conocer previamente las concentraciones de los metabolitos o los detalles de la cinética enzimática del sistema. Se asume que el sistema bajo estudio se encuentra en estado estacionario. La técnica entonces intenta responder a la pregunta: dados algunos nutrientes conocidos, ¿cuál es el conjunto de flujos metabólicos que maximizan la tasa de crecimiento de un organismo preservando la concentración interna de metabolitos? Un ejemplo notable del éxito del ABF es la capacidad de predecir con precisión la tasa de crecimiento del procarionte E. coli al ser cultivado en diferentes condiciones. Los organismos apropiados para este análisis pueden ser cultivados en concentraciones de nutrientes definidas, midiendo sus tasas de crecimiento. Estas tasas de crecimiento experimentales son comparadas con las predicciones del ABF, lo que permite corregir el modelo con las observaciones. Una buena descripción de los conceptos básicos de ABF se encuentra en el material suplementario de Edwards et al. 2001 (texto en inglés) el cuál puede consultarse en el sitio web de Nature. Otros recursos son el libro "Systems Biology" de B. Palsson, y artículos por J. Orth,por Lee et al. 2006 y Feist et al. 2008.por Lee et al. 2006 y Feist et al. 2008.
, Анализ баланса потоков (АМП) (англ. flux b … Анализ баланса потоков (АМП) (англ. flux balance analysis, FBA), — метод математического моделирования метаболизма, позволяющий определить скорость реакций в метаболической сети (одном пути или наборе путей). Метод применяется в моделировании разных воздействий на клетку или оптимизации условий её роста. Ключевыми особенностями метода являются использование стационарного приближения (допущения, при котором концентрация каждого вещества считается постоянной) и малая потребность в вычислительной мощности.лая потребность в вычислительной мощности.
, 대사유체는 세포내외의 대사물들의 흐름의 총체를 말한다. 이것은 대사체와 비교되는 말로서 flux balance분석에서 모든 대사체들간의 정량화의 총체를 의미한다. 이것은 체학의 등장에 따라 생겨난 신조어이다.
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Flux balance analysis (FBA) is a mathemati … Flux balance analysis (FBA) is a mathematical method for simulating metabolism in genome-scale reconstructions of metabolic networks. In comparison to traditional methods of modeling, FBA is less intensive in terms of the input data required for constructing the model. Simulations performed using FBA are computationally inexpensive and can calculate steady-state metabolic fluxes for large models (over 2000 reactions) in a few seconds on modern personal computers. The related method of metabolic pathway analysis seeks to find and list all possible pathways between metabolites.all possible pathways between metabolites.
, Анализ баланса потоков (АМП) (англ. flux b … Анализ баланса потоков (АМП) (англ. flux balance analysis, FBA), — метод математического моделирования метаболизма, позволяющий определить скорость реакций в метаболической сети (одном пути или наборе путей). Метод применяется в моделировании разных воздействий на клетку или оптимизации условий её роста. Ключевыми особенностями метода являются использование стационарного приближения (допущения, при котором концентрация каждого вещества считается постоянной) и малая потребность в вычислительной мощности.лая потребность в вычислительной мощности.
, El análisis de balance de flujo (ABF) es u … El análisis de balance de flujo (ABF) es un método matemático para analizar el metabolismo en un sistema biológico. A diferencia de otros métodos de modelaje, no requiere conocer previamente las concentraciones de los metabolitos o los detalles de la cinética enzimática del sistema. Se asume que el sistema bajo estudio se encuentra en estado estacionario. La técnica entonces intenta responder a la pregunta: dados algunos nutrientes conocidos, ¿cuál es el conjunto de flujos metabólicos que maximizan la tasa de crecimiento de un organismo preservando la concentración interna de metabolitos?o la concentración interna de metabolitos?
, 대사유체는 세포내외의 대사물들의 흐름의 총체를 말한다. 이것은 대사체와 비교되는 말로서 flux balance분석에서 모든 대사체들간의 정량화의 총체를 의미한다. 이것은 체학의 등장에 따라 생겨난 신조어이다.
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Análisis de balance de flujo
, Flux balance analysis
, 대사유체
, Анализ метаболических потоков
|
