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The type 2 secretion system (often referre … The type 2 secretion system (often referred to as the type II secretion system or by the initials T2SS) is a type of protein secretion machinery found in various species of Gram-negative bacteria, including many human pathogens such as Pseudomonas aeruginosa and Vibrio cholerae. The type II secretion system is one of six protein secretory systems commonly found in Gram-negative bacteria, along with the type I, type III, and type IV secretion systems, as well as the chaperone/usher pathway, the autotransporter pathway/type V secretion system, and the type VI secretion system (some bacteria also utilize the type VII secretion system). Like these other systems, the type II secretion system enables the transport of cytoplasmic proteins across the lipid bilayers that make up the cell membranes of Gram-negative bacteria. Secretion of proteins and effector molecules out of the cell plays a critical role in signaling other cells and in the invasion and parasitism of host cells.the invasion and parasitism of host cells.
, Das Sec-System ist ein Proteinkomplex und … Das Sec-System ist ein Proteinkomplex und dient dem Transport von Proteinen über oder in die Zytoplasmamembran bei Bakterien und höheren Zellen. Es kommt bei den Typen II, IV und V der bakteriellen Proteinsekretion in Gram-negativen Bakterien vor. Es handelt sich um Transportproteine aus der Familie der Membran-ATPasen. Man unterscheidet in cotranslationalen Proteintransport und posttranslationalen Proteintransport. Das Sec-System kann beide Transportformen durchführen, im Gegensatz zum Tat-System, welches nur posttranslational gefaltete Proteine transportiert. Es besteht aus einem Chaperon und einem Multiproteinkomplex, der als Translokase dient. Das als Chaperon wirkende SecB-Protein bindet an das neu synthetisierte Protein und verhindert dessen vorzeitige Faltung. Der Transportmotor SecA erkennt die Signalsequenz, bringt das Protein an den Translocator aus SecY, SecE, SecG, SecD und SecF und liefert durch ATP-Hydrolyse die Energie für den Transfer über die Membran. Die Transportgleichung für Sec-Systeme lautet: ATP + pmf + Präprotein (Zytoplasma) ⇔ ADP + Pi + Präprotein (Periplasma oder Zytoplasmamembran) Der Begriff Sec-System ist abgeleitet von Sekretion.f Sec-System ist abgeleitet von Sekretion.
, Sistem sekresi tipe II atau tipe 2 (dising … Sistem sekresi tipe II atau tipe 2 (disingkat T2SS dalam bahasa Inggris) adalah suatu sistem sekresi protein yang terdapat dalam berbagai bakteri gram-negatif, termasuk berbagai patogen pada manusia, seperti Pseudomonas aeruginosa dan Vibrio cholerae. Sistem sekresi tipe II adalah satu dari enam jenis sistem sekresi protein yang umum ditemui pada bakteri gram-negatif. Seperti sistem-sistem lainnya, sistem sekresi tipe II membuka jalan bagi pemindahan protein sitoplasmik melintasi lipida dwilapis pada membran sel bakteri gram-negatif. Sistem ini terdiri dari dua tahap. Tahap pertama menggunakan jalur sekresi Sec dan yang memindahkan protein melintasi membran dalam menuju periplasma. Setelah protein yang disekresikan berada di periplasma, terjadilah tahap kedua dan protein tersebut dikeluarkan dari sel.dan protein tersebut dikeluarkan dari sel.
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| rdfs:comment |
The type 2 secretion system (often referre … The type 2 secretion system (often referred to as the type II secretion system or by the initials T2SS) is a type of protein secretion machinery found in various species of Gram-negative bacteria, including many human pathogens such as Pseudomonas aeruginosa and Vibrio cholerae. The type II secretion system is one of six protein secretory systems commonly found in Gram-negative bacteria, along with the type I, type III, and type IV secretion systems, as well as the chaperone/usher pathway, the autotransporter pathway/type V secretion system, and the type VI secretion system (some bacteria also utilize the type VII secretion system). Like these other systems, the type II secretion system enables the transport of cytoplasmic proteins across the lipid bilayers that make up the cell membranes bilayers that make up the cell membranes
, Sistem sekresi tipe II atau tipe 2 (dising … Sistem sekresi tipe II atau tipe 2 (disingkat T2SS dalam bahasa Inggris) adalah suatu sistem sekresi protein yang terdapat dalam berbagai bakteri gram-negatif, termasuk berbagai patogen pada manusia, seperti Pseudomonas aeruginosa dan Vibrio cholerae. Sistem sekresi tipe II adalah satu dari enam jenis sistem sekresi protein yang umum ditemui pada bakteri gram-negatif. Seperti sistem-sistem lainnya, sistem sekresi tipe II membuka jalan bagi pemindahan protein sitoplasmik melintasi lipida dwilapis pada membran sel bakteri gram-negatif.pis pada membran sel bakteri gram-negatif.
, Das Sec-System ist ein Proteinkomplex und … Das Sec-System ist ein Proteinkomplex und dient dem Transport von Proteinen über oder in die Zytoplasmamembran bei Bakterien und höheren Zellen. Es kommt bei den Typen II, IV und V der bakteriellen Proteinsekretion in Gram-negativen Bakterien vor. Es handelt sich um Transportproteine aus der Familie der Membran-ATPasen. Die Transportgleichung für Sec-Systeme lautet: ATP + pmf + Präprotein (Zytoplasma) ⇔ ADP + Pi + Präprotein (Periplasma oder Zytoplasmamembran) Der Begriff Sec-System ist abgeleitet von Sekretion.f Sec-System ist abgeleitet von Sekretion.
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| rdfs:label |
Type II secretion system
, Sistem sekresi tipe II
, Sec-System
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