| Birthplace
|
http://dbpedia.org/resource/Chicago +
|
| http://dbpedia.org/ontology/abstract
|
Mark Ptashne (born June 5, 1940, in Chicag … Mark Ptashne (born June 5, 1940, in Chicago) is a molecular biologist. He is the Ludwig Chair of Molecular Biology at Memorial Sloan–Kettering Cancer Center in New York City. Ptashne grew up in Chicago. He earned his undergraduate degree at Reed College in Portland, Oregon in 1961 and his PhD from Harvard in 1968, after which he joined the faculty of Harvard. He was made professor there in 1971 and became chair of the Department of Biochemistry and Molecular Biology in 1980. In 1993 he was awarded an endowed chair, and in 1997 he left Harvard for MSK. The focus of his scientific career has been gene regulation. Ptashne was the first scientist to demonstrate specific binding between protein and DNA, and his lifelong work has been the elucidation of the molecular mechanisms of switch between lytic and lysogenic lifecyle of bacteriophage lambda, as well as how the yeast transcriptional activator Gal4 works. He was the originator of the "ball and stick" model of transcription factor function, demonstrating in bacteria and in yeast that they typically consist of separable regions that mediate DNA binding and interaction with transcriptional activators or repressors. In 1980 he cofounded Genetics Institute, Inc. with Thomas Maniatis. The founding of a company by a Harvard scientist was something new at the time, and was very controversial. In 1985, he was awarded the Louisa Gross Horwitz Prize from Columbia University. He won the Albert Lasker Award for Basic Medical Research in 1997, and the Massry Prize from the Keck School of Medicine, University of Southern California in 1998. He has written popular books for a wider scientific audience, including his book Genes and Signals. Selected worksBooks
* Ptashne, M; Gann, A (2002). Genes and Signals. Cold Harbor Spring Laboratory Press. ISBN 978-0-87969-633-7.
* Ptashne, M (2004). A Genetic Switch: Phage Lambda Revisited (3rd ed.). Cold Harbor Spring Laboratory Press. ISBN 978-0-87969-716-7.Papers
* Ptashne, M (1967). "Specific Binding of the λ Phage Repressor to λ DNA". Nature. 214 (5085): 232–234. Bibcode:1967Natur.214..232P. doi:10.1038/214232a0. PMID 6034235. S2CID 4209094.
* Ptashne, M; et al. (1980). "How the λ repressor and cro work". Cell. 19 (1): 1–11. doi:10.1016/0092-8674(80)90383-9. PMID 6444544. S2CID 54281357.
* Ptashne, M. (2011). "Horace Judson (1931–2011)". PLOS Biology. 9 (7): e1001104. doi:10.1371/journal.pbio.1001104. PMC 3134443.10.1371/journal.pbio.1001104. PMC 3134443.
, マーク・スティーヴン・プタシュネ(Mark Steven Ptashne、1940年6月5日 - )はアメリカ合衆国の分子生物学者。転写因子による遺伝子発現の研究で知られる。シカゴ出身。 1961年オレゴン州ポートランドのリード大学で化学の学士号を、1968年ハーバード大学で分子生物学の博士号を取得。1971年同大学教授に就任し、1997年よりニューヨークのスローン・ケタリング記念癌センター教授。
, Mark Ptashne, né le 5 juin 1940 à Chicago, est biologiste moléculaire.
, Mark Steven Ptashne (* 5. Juni 1940 in Chicago) ist ein US-amerikanischer Molekularbiologe und Professor am Memorial Sloan-Kettering Cancer Center.
, Марк Ташне (англ. Mark Ptashne, род. 5 июн … Марк Ташне (англ. Mark Ptashne, род. 5 июня 1940, Чикаго, США) — американский молекулярный биолог и скрипач. Был первым ученым, показавшим специфическое связывание белка и ДНК. Всю жизнь работал над исследованием механизма переключение между лизисом и лизогенией бактериофага λ и механизмом действия активатора транскрипции Gal4 дрожжей. Впервые продемонстрировал, что транскрипционные факторы бактерий дрожжей имеют два раздельных региона для связывания ДНК и взаимодействия с активаторами или репрессорами. В 1980 году, совместно с Томасом Маниатисом, основал компанию , которая была впоследствии приобретена компанией Wyeth в 1996 году. Является автором популярных книг по молекулярной биологии и биохимии. книг по молекулярной биологии и биохимии.
, 马克·普塔什尼（英語：Mark Ptashne，1940年6月5日－），美国分子生物学家和小提琴家。他目前担任纽约的纪念斯隆 - 凯特琳癌症中心分子路德维希生物学主席。
, Mark Steven Ptashne (Chicago, 5 de junho de 1940) é um biólogo molecular estadunidense.
|
| http://dbpedia.org/ontology/academicDiscipline
|
http://dbpedia.org/resource/Molecular_Biology +
|
| http://dbpedia.org/ontology/almaMater
|
http://dbpedia.org/resource/Harvard_University +
, http://dbpedia.org/resource/Reed_College +
|
| http://dbpedia.org/ontology/award
|
http://dbpedia.org/resource/NAS_Award_in_Molecular_Biology +
, http://dbpedia.org/resource/Lasker_Award +
, http://dbpedia.org/resource/Massry_Prize +
, http://dbpedia.org/resource/Louisa_Gross_Horwitz_Prize +
|
| http://dbpedia.org/ontology/birthDate
|
"1940-06-05"^^xsd:date
|
| http://dbpedia.org/ontology/institution
|
http://dbpedia.org/resource/Memorial_Sloan%E2%80%93Kettering_Cancer_Center +
|
| http://dbpedia.org/ontology/thumbnail
|
http://commons.wikimedia.org/wiki/Special:FilePath/Nci-vol-8185-300_mark_ptashne.jpg?width=300 +
|
| http://dbpedia.org/ontology/wikiPageExternalLink
|
https://web.archive.org/web/20080516085153/http:/www.cooperstownmusicfest.org/Artists/Ptashne/Ptashne.htm +
, http://www.mskcc.org/mskcc/html/10387.cfm +
|
| http://dbpedia.org/ontology/wikiPageID
|
19619508
|
| http://dbpedia.org/ontology/wikiPageLength
|
5591
|
| http://dbpedia.org/ontology/wikiPageRevisionID
|
1120846869
|
| http://dbpedia.org/ontology/wikiPageWikiLink
|
http://dbpedia.org/resource/Louisa_Gross_Horwitz_Prize +
, http://dbpedia.org/resource/Transcription_factor +
, http://dbpedia.org/resource/Albert_Lasker_Award_for_Basic_Medical_Research +
, http://dbpedia.org/resource/Lytic +
, http://dbpedia.org/resource/Keck_School_of_Medicine +
, http://dbpedia.org/resource/Category:Members_of_the_United_States_National_Academy_of_Sciences +
, http://dbpedia.org/resource/Lysogenic +
, http://dbpedia.org/resource/University_of_Southern_California +
, http://dbpedia.org/resource/Harvard_University +
, http://dbpedia.org/resource/Category:Massry_Prize_recipients +
, http://dbpedia.org/resource/Molecular_biology +
, http://dbpedia.org/resource/Gene_regulation +
, http://dbpedia.org/resource/Lambda_phage +
, http://dbpedia.org/resource/Chicago +
, http://dbpedia.org/resource/Category:21st-century_violinists +
, http://dbpedia.org/resource/Category:Harvard_University_faculty +
, http://dbpedia.org/resource/Category:Harvard_University_alumni +
, http://dbpedia.org/resource/Category:Reed_College_alumni +
, http://dbpedia.org/resource/Massry_Prize +
, http://dbpedia.org/resource/Gal4_transcription_factor +
, http://dbpedia.org/resource/Category:American_molecular_biologists +
, http://dbpedia.org/resource/Lasker_Award +
, http://dbpedia.org/resource/NAS_Award_in_Molecular_Biology +
, http://dbpedia.org/resource/Category:Living_people +
, http://dbpedia.org/resource/Columbia_University +
, http://dbpedia.org/resource/Portland%2C_Oregon +
, http://dbpedia.org/resource/Memorial_Sloan%E2%80%93Kettering_Cancer_Center +
, http://dbpedia.org/resource/Category:Jewish_biologists +
, http://dbpedia.org/resource/Category:Recipients_of_the_Albert_Lasker_Award_for_Basic_Medical_Research +
, http://dbpedia.org/resource/Thomas_Maniatis +
, http://dbpedia.org/resource/New_York_City +
, http://dbpedia.org/resource/Category:1940_births +
, http://dbpedia.org/resource/Molecular_Biology +
, http://dbpedia.org/resource/Genetics_Institute%2C_Inc. +
, http://dbpedia.org/resource/Reed_College +
|
| http://dbpedia.org/property/almaMater
|
http://dbpedia.org/resource/Reed_College +
, http://dbpedia.org/resource/Harvard_University +
|
| http://dbpedia.org/property/awards
|
Massry Prize
, Louisa Gross Horwitz Prize
, Lasker Award
, NAS Award in Molecular Biology
|
| http://dbpedia.org/property/birthDate
|
"1940-06-05"^^xsd:date
|
| http://dbpedia.org/property/birthPlace
|
http://dbpedia.org/resource/Chicago +
|
| http://dbpedia.org/property/fields
|
http://dbpedia.org/resource/Molecular_Biology +
|
| http://dbpedia.org/property/name
|
Mark Ptashne
|
| http://dbpedia.org/property/wikiPageUsesTemplate
|
http://dbpedia.org/resource/Template:Cite_book +
, http://dbpedia.org/resource/Template:Eli_Lilly_Award_in_Biological_Chemistry +
, http://dbpedia.org/resource/Template:Birth_date_and_age +
, http://dbpedia.org/resource/Template:Reflist +
, http://dbpedia.org/resource/Template:Infobox_scientist +
, http://dbpedia.org/resource/Template:US-violinist-stub +
, http://dbpedia.org/resource/Template:Authority_control +
, http://dbpedia.org/resource/Template:Small +
, http://dbpedia.org/resource/Template:US-biologist-stub +
, http://dbpedia.org/resource/Template:Cite_journal +
|
| http://dbpedia.org/property/workplaces
|
http://dbpedia.org/resource/Memorial_Sloan%E2%80%93Kettering_Cancer_Center +
|
| http://purl.org/dc/terms/subject
|
http://dbpedia.org/resource/Category:Living_people +
, http://dbpedia.org/resource/Category:21st-century_violinists +
, http://dbpedia.org/resource/Category:Massry_Prize_recipients +
, http://dbpedia.org/resource/Category:1940_births +
, http://dbpedia.org/resource/Category:Harvard_University_faculty +
, http://dbpedia.org/resource/Category:Jewish_biologists +
, http://dbpedia.org/resource/Category:Reed_College_alumni +
, http://dbpedia.org/resource/Category:Recipients_of_the_Albert_Lasker_Award_for_Basic_Medical_Research +
, http://dbpedia.org/resource/Category:Harvard_University_alumni +
, http://dbpedia.org/resource/Category:American_molecular_biologists +
, http://dbpedia.org/resource/Category:Members_of_the_United_States_National_Academy_of_Sciences +
|
| http://purl.org/linguistics/gold/hypernym
|
http://dbpedia.org/resource/Biologist +
|
| http://schema.org/sameAs
|
http://viaf.org/viaf/79149901 +
|
| http://www.w3.org/ns/prov#wasDerivedFrom
|
http://en.wikipedia.org/wiki/Mark_Ptashne?oldid=1120846869&ns=0 +
|
| http://xmlns.com/foaf/0.1/depiction
|
http://commons.wikimedia.org/wiki/Special:FilePath/Nci-vol-8185-300_mark_ptashne.jpg +
|
| http://xmlns.com/foaf/0.1/isPrimaryTopicOf
|
http://en.wikipedia.org/wiki/Mark_Ptashne +
|
| http://xmlns.com/foaf/0.1/name
|
Mark Ptashne
|
| owl:sameAs |
http://d-nb.info/gnd/138150850 +
, https://global.dbpedia.org/id/pvEH +
, http://pt.dbpedia.org/resource/Mark_Ptashne +
, http://dbpedia.org/resource/Mark_Ptashne +
, http://ru.dbpedia.org/resource/%D0%A2%D0%B0%D1%88%D0%BD%D0%B5%2C_%D0%9C%D0%B0%D1%80%D0%BA +
, http://www.wikidata.org/entity/Q1900363 +
, http://zh.dbpedia.org/resource/%E9%A9%AC%E5%85%8B%C2%B7%E6%99%AE%E5%A1%94%E4%BB%80%E5%B0%BC +
, http://de.dbpedia.org/resource/Mark_Ptashne +
, http://rdf.freebase.com/ns/m.04n0vj6 +
, http://yago-knowledge.org/resource/Mark_Ptashne +
, http://viaf.org/viaf/79149901 +
, http://arz.dbpedia.org/resource/%D9%85%D8%A7%D8%B1%D9%83_%D8%A8%D8%AA%D8%A7%D8%B4%D9%86%D9%89 +
, http://ja.dbpedia.org/resource/%E3%83%9E%E3%83%BC%E3%82%AF%E3%83%BB%E3%83%97%E3%82%BF%E3%82%B7%E3%83%A5%E3%83%8D +
, http://data.bibliotheken.nl/id/thes/p071884432 +
, http://fr.dbpedia.org/resource/Mark_Ptashne +
|
| rdf:type |
http://dbpedia.org/class/yago/MolecularBiologist110327143 +
, http://dbpedia.org/ontology/Eukaryote +
, http://dbpedia.org/class/yago/WikicatAmericanBiologists +
, http://dbpedia.org/class/yago/WikicatAmericanPeople +
, http://dbpedia.org/class/yago/Associate109816771 +
, http://dbpedia.org/class/yago/Whole100003553 +
, http://dbpedia.org/class/yago/WikicatLivingPeople +
, http://dbpedia.org/class/yago/WikicatGuggenheimFellows +
, http://dbpedia.org/class/yago/YagoLegalActorGeo +
, http://dbpedia.org/ontology/Species +
, http://dbpedia.org/class/yago/YagoLegalActor +
, http://dbpedia.org/class/yago/Object100002684 +
, http://www.wikidata.org/entity/Q729 +
, http://dbpedia.org/class/yago/Person100007846 +
, http://www.wikidata.org/entity/Q5 +
, http://dbpedia.org/class/yago/Scientist110560637 +
, http://dbpedia.org/ontology/Scientist +
, http://dbpedia.org/class/yago/Colleague109935990 +
, http://www.wikidata.org/entity/Q215627 +
, http://dbpedia.org/class/yago/Peer109626238 +
, http://www.wikidata.org/entity/Q19088 +
, http://dbpedia.org/class/yago/Alumnus109786338 +
, http://dbpedia.org/class/yago/Scholar110557854 +
, http://schema.org/Person +
, http://dbpedia.org/class/yago/Intellectual109621545 +
, http://xmlns.com/foaf/0.1/Person +
, http://www.wikidata.org/entity/Q901 +
, http://dbpedia.org/class/yago/WikicatReedCollegeAlumni +
, http://www.ontologydesignpatterns.org/ont/dul/DUL.owl#NaturalPerson +
, http://dbpedia.org/class/yago/LivingThing100004258 +
, http://dbpedia.org/ontology/Person +
, http://dbpedia.org/class/yago/PhysicalEntity100001930 +
, http://dbpedia.org/class/yago/Biologist109855630 +
, http://dbpedia.org/class/yago/Organism100004475 +
, http://dbpedia.org/class/yago/WikicatBiologists +
, http://dbpedia.org/class/yago/WikicatMolecularBiologists +
, http://dbpedia.org/class/yago/CausalAgent100007347 +
, http://dbpedia.org/ontology/Animal +
|
| rdfs:comment |
Mark Steven Ptashne (* 5. Juni 1940 in Chicago) ist ein US-amerikanischer Molekularbiologe und Professor am Memorial Sloan-Kettering Cancer Center.
, 马克·普塔什尼（英語：Mark Ptashne，1940年6月5日－），美国分子生物学家和小提琴家。他目前担任纽约的纪念斯隆 - 凯特琳癌症中心分子路德维希生物学主席。
, Марк Ташне (англ. Mark Ptashne, род. 5 июн … Марк Ташне (англ. Mark Ptashne, род. 5 июня 1940, Чикаго, США) — американский молекулярный биолог и скрипач. Был первым ученым, показавшим специфическое связывание белка и ДНК. Всю жизнь работал над исследованием механизма переключение между лизисом и лизогенией бактериофага λ и механизмом действия активатора транскрипции Gal4 дрожжей. Впервые продемонстрировал, что транскрипционные факторы бактерий дрожжей имеют два раздельных региона для связывания ДНК и взаимодействия с активаторами или репрессорами. В 1980 году, совместно с Томасом Маниатисом, основал компанию , которая была впоследствии приобретена компанией Wyeth в 1996 году. Является автором популярных книг по молекулярной биологии и биохимии. книг по молекулярной биологии и биохимии.
, Mark Steven Ptashne (Chicago, 5 de junho de 1940) é um biólogo molecular estadunidense.
, Mark Ptashne (born June 5, 1940, in Chicag … Mark Ptashne (born June 5, 1940, in Chicago) is a molecular biologist. He is the Ludwig Chair of Molecular Biology at Memorial Sloan–Kettering Cancer Center in New York City. Ptashne grew up in Chicago. He earned his undergraduate degree at Reed College in Portland, Oregon in 1961 and his PhD from Harvard in 1968, after which he joined the faculty of Harvard. He was made professor there in 1971 and became chair of the Department of Biochemistry and Molecular Biology in 1980. In 1993 he was awarded an endowed chair, and in 1997 he left Harvard for MSK.hair, and in 1997 he left Harvard for MSK.
, Mark Ptashne, né le 5 juin 1940 à Chicago, est biologiste moléculaire.
, マーク・スティーヴン・プタシュネ(Mark Steven Ptashne、1940年6月5日 - )はアメリカ合衆国の分子生物学者。転写因子による遺伝子発現の研究で知られる。シカゴ出身。 1961年オレゴン州ポートランドのリード大学で化学の学士号を、1968年ハーバード大学で分子生物学の博士号を取得。1971年同大学教授に就任し、1997年よりニューヨークのスローン・ケタリング記念癌センター教授。
|
| rdfs:label |
Mark Ptashne
, Ташне, Марк
, マーク・プタシュネ
, 马克·普塔什尼
|
