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|
JNJ-7777120 was a drug being developed by … JNJ-7777120 was a drug being developed by Johnson & Johnson Pharmaceutical Research & Development which acts as a potent and selective antagonist at the histamine H4 receptor. It has anti-inflammatory effects, and has been demonstrated to be superior to traditional (H1) antihistamines in the treatment of pruritus (itching). The drug was abandoned because of its short in vivo half-life and hypoadrenocorticism toxicity in rats and dogs, that prevented advancing it into clinical studies.vented advancing it into clinical studies.
, JNJ-7777120 är ett läkemedel utvecklat av . Läkemedlet har antiflammatoriska effekter.
|
| http://dbpedia.org/ontology/casNumber
|
459168-41-3
|
| http://dbpedia.org/ontology/chEMBL
|
129198
|
| http://dbpedia.org/ontology/fdaUniiCode
|
4H1AU2V37X
|
| http://dbpedia.org/ontology/pubchem
|
4908365
|
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|
http://commons.wikimedia.org/wiki/Special:FilePath/JNJ-7777120.svg?width=300 +
|
| http://dbpedia.org/ontology/wikiPageID
|
18687255
|
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|
3706
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|
1120073178
|
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|
http://dbpedia.org/resource/Hypoadrenocorticism +
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, http://dbpedia.org/resource/Receptor_antagonist +
, http://dbpedia.org/resource/Category:Chloroarenes +
, http://dbpedia.org/resource/Category:Carboxamides +
, http://dbpedia.org/resource/Anti-inflammatory +
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|
| http://dbpedia.org/property/alt
|
Ball-and-stick model of the JNJ-7777120 molecule
, Skeletal formula of JNJ-7777120
|
| http://dbpedia.org/property/c
|
14
|
| http://dbpedia.org/property/casNumber
|
459168
|
| http://dbpedia.org/property/chembl
|
129198
|
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4090750
|
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1
|
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16
|
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JNJ-7777120-3D-spacefill.png
|
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5
|
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|
1278
|
| http://dbpedia.org/property/n
|
3
|
| http://dbpedia.org/property/o
|
1
|
| http://dbpedia.org/property/pubchem
|
4908365
|
| http://dbpedia.org/property/smiles
|
C3CNCCN3Cc[nH]c1ccc2Cl
|
| http://dbpedia.org/property/stdinchi
|
1
|
| http://dbpedia.org/property/stdinchikey
|
HUQJRYMLJBBEDO-UHFFFAOYSA-N
|
| http://dbpedia.org/property/synonyms
|
(1-[carbonyl]-4-methylpiperazine)
|
| http://dbpedia.org/property/unii
|
4
|
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|
changed
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394360889
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|
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|
| rdfs:comment |
JNJ-7777120 was a drug being developed by … JNJ-7777120 was a drug being developed by Johnson & Johnson Pharmaceutical Research & Development which acts as a potent and selective antagonist at the histamine H4 receptor. It has anti-inflammatory effects, and has been demonstrated to be superior to traditional (H1) antihistamines in the treatment of pruritus (itching). The drug was abandoned because of its short in vivo half-life and hypoadrenocorticism toxicity in rats and dogs, that prevented advancing it into clinical studies.vented advancing it into clinical studies.
, JNJ-7777120 är ett läkemedel utvecklat av . Läkemedlet har antiflammatoriska effekter.
|
| rdfs:label |
JNJ-7777120
|
