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تشتمل الكاتيكولامينات الموجودة في الجسم عل … تشتمل الكاتيكولامينات الموجودة في الجسم على مواد داخلية التنشؤ مثل الدوبامين والنورإبينفرين (نورأدرينالين) والإبينفرين (الأدرينالين)؛ بالإضافة إلى العديد من المركبات المصطنعة مثل الإيزوبرينالين. كانت الأبحاث التي أدت إلى اكتشاف هذه المركبات فصلاً بارزاً في تاريخ علم وظائف الأعضاء (الفيزيولوجيا) والكيمياء الحيوية والصيدلة. كان الأدرينالين أول هرمون استخرج من الغدد الصمّاء واستحصل عليه بصورة نقية قبل صياغة كلمة هرمون. وكان أيضاً أول هرمون تم توضيح بنيته واصطناعه الحيوي. بصرف النظر عن أستيل كولين، فقد كان الأدرينالين والنورأدرينالين أول نواقل عصبية يتم اكتشافها، وكانت أول إشارات كيميائية حيوية يتم العثور عليها في الحويصلات داخل الخلايا.تم العثور عليها في الحويصلات داخل الخلايا.
, The catecholamines comprise the endogenous … The catecholamines comprise the endogenous substances dopamine, noradrenaline (norepinephrine), and adrenaline (epinephrine), as well as numerous artificially synthesized compounds such as isoprenaline, an anti-bradycardiac medication. Their investigation comprises a major chapter in the history of physiology, biochemistry, and pharmacology. Adrenaline was the first hormone extracted from an endocrine gland and obtained in pure form, before the word hormone was coined. Adrenaline was also the first hormone whose structure and biosynthesis were discovered. Second to acetylcholine, adrenaline and noradrenaline were some of the first neurotransmitters discovered, and the first intercellular biochemical signals to be found in intracellular vesicles. The β-adrenoceptor was the first G protein-coupled receptor whose gene was cloned.in-coupled receptor whose gene was cloned.
, Zu den Katecholaminen (bzw. Catecholaminen … Zu den Katecholaminen (bzw. Catecholaminen) oder Brenzcatechinaminen gehören die körpereigenen Stoffe Dopamin, Noradrenalin (Norepinephrin) und Adrenalin (Epinephrin) sowie zahlreiche künstlich hergestellte Substanzen, unter denen Isoprenalin hervorzuheben ist. Ihre Erforschung bildet ein wichtiges Kapitel der Geschichte der Physiologie, Biochemie und Pharmakologie. Adrenalin war das erste aus einer endokrinen Drüse extrahierte, das erste rein dargestellte und das erste in seiner Struktur und Biosynthese geklärte Hormon, vor der Prägung des Wortes „Hormon“. Adrenalin und Noradrenalin waren neben Acetylcholin die erstentdeckten Neurotransmitter und die ersten Botenstoffe, die in intrazellulären Vesikeln gespeichert gefunden wurden. Der β-Adrenozeptor war der erste G-Protein-gekoppelte Hormon- und Neurotransmitterrezeptor, dessen Gen kloniert wurde. Die zielgerichtete Katecholaminforschung begann mit der Herstellung eines pharmakologisch wirksamen Extraktes aus Nebennieren durch George Oliver und Edward Albert Schäfer in den Jahren 1893 und 1894. Doch gab es frühere Hinweise.93 und 1894. Doch gab es frühere Hinweise.
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تشتمل الكاتيكولامينات الموجودة في الجسم عل … تشتمل الكاتيكولامينات الموجودة في الجسم على مواد داخلية التنشؤ مثل الدوبامين والنورإبينفرين (نورأدرينالين) والإبينفرين (الأدرينالين)؛ بالإضافة إلى العديد من المركبات المصطنعة مثل الإيزوبرينالين. كانت الأبحاث التي أدت إلى اكتشاف هذه المركبات فصلاً بارزاً في تاريخ علم وظائف الأعضاء (الفيزيولوجيا) والكيمياء الحيوية والصيدلة. كان الأدرينالين أول هرمون استخرج من الغدد الصمّاء واستحصل عليه بصورة نقية قبل صياغة كلمة هرمون. وكان أيضاً أول هرمون تم توضيح بنيته واصطناعه الحيوي. بصرف النظر عن أستيل كولين، فقد كان الأدرينالين والنورأدرينالين أول نواقل عصبية يتم اكتشافها، وكانت أول إشارات كيميائية حيوية يتم العثور عليها في الحويصلات داخل الخلايا.تم العثور عليها في الحويصلات داخل الخلايا.
, Zu den Katecholaminen (bzw. Catecholaminen … Zu den Katecholaminen (bzw. Catecholaminen) oder Brenzcatechinaminen gehören die körpereigenen Stoffe Dopamin, Noradrenalin (Norepinephrin) und Adrenalin (Epinephrin) sowie zahlreiche künstlich hergestellte Substanzen, unter denen Isoprenalin hervorzuheben ist. Ihre Erforschung bildet ein wichtiges Kapitel der Geschichte der Physiologie, Biochemie und Pharmakologie. Adrenalin war das erste aus einer endokrinen Drüse extrahierte, das erste rein dargestellte und das erste in seiner Struktur und Biosynthese geklärte Hormon, vor der Prägung des Wortes „Hormon“. Adrenalin und Noradrenalin waren neben Acetylcholin die erstentdeckten Neurotransmitter und die ersten Botenstoffe, die in intrazellulären Vesikeln gespeichert gefunden wurden. Der β-Adrenozeptor war der erste G-Protein-gekoppelte Hormor war der erste G-Protein-gekoppelte Hormo
, The catecholamines comprise the endogenous … The catecholamines comprise the endogenous substances dopamine, noradrenaline (norepinephrine), and adrenaline (epinephrine), as well as numerous artificially synthesized compounds such as isoprenaline, an anti-bradycardiac medication. Their investigation comprises a major chapter in the history of physiology, biochemistry, and pharmacology. Adrenaline was the first hormone extracted from an endocrine gland and obtained in pure form, before the word hormone was coined. Adrenaline was also the first hormone whose structure and biosynthesis were discovered. Second to acetylcholine, adrenaline and noradrenaline were some of the first neurotransmitters discovered, and the first intercellular biochemical signals to be found in intracellular vesicles. The β-adrenoceptor was the first G protein-ce β-adrenoceptor was the first G protein-c
|
| rdfs:label |
تاريخ أبحاث الكاتيكولامينات
, Geschichte der Katecholaminforschung
, History of catecholamine research
|
