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|
Group II introns are a large class of self … Group II introns are a large class of self-catalytic ribozymes and mobile genetic elements found within the genes of all three domains of life. Ribozyme activity (e.g., self-splicing) can occur under high-salt conditions in vitro. However, assistance from proteins is required for in vivo splicing. In contrast to group I introns, intron excision occurs in the absence of GTP and involves the formation of a lariat, with an A-residue branchpoint strongly resembling that found in lariats formed during splicing of nuclear pre-mRNA. It is hypothesized that pre-mRNA splicing (see spliceosome) may have evolved from group II introns, due to the similar catalytic mechanism as well as the structural similarity of the Group II Domain V substructure to the U6/U2 extended snRNA. Finally, their ability to site-specifically insert into DNA sites has been exploited as a tool for biotechnology. For example, group II introns can be modified to make site-specific genome insertions and deliver cargo DNA such as reporter genes or lox sitesgo DNA such as reporter genes or lox sites
|
| http://dbpedia.org/ontology/symbol
|
Domain_X
, GIIM
|
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|
http://commons.wikimedia.org/wiki/Special:FilePath/IntronGroupII.jpg?width=300 +
|
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|
7916185
|
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|
14774
|
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|
1112937161
|
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http://dbpedia.org/resource/RNA_splicing +
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, http://dbpedia.org/resource/Group_III_intron +
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, http://dbpedia.org/resource/Guanosine_triphosphate +
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|
| http://dbpedia.org/property/caption
|
full secondary structure of group II intron
|
| http://dbpedia.org/property/extra
|
300.0
, 180.0
|
| http://dbpedia.org/property/interpro
|
IPR013597
, IPR024937
|
| http://dbpedia.org/property/name
|
Group II catalytic intron, D1-D4
, Group II intron, maturase-specific
, Group II catalytic intron, D5
, Domain X
|
| http://dbpedia.org/property/pdb
|
4
, 6
|
| http://dbpedia.org/property/pfam
|
PF08388
, PF01348
|
| http://dbpedia.org/property/pfamClan
|
CL0359
|
| http://dbpedia.org/property/rfam
|
RF00029
|
| http://dbpedia.org/property/rfamClan
|
CL00102
|
| http://dbpedia.org/property/symbol
|
Intron_gpII
, GIIM
, Domain_X
, group-II-D1D4
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http://dbpedia.org/resource/Category:Ribozymes +
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|
| rdfs:comment |
Group II introns are a large class of self … Group II introns are a large class of self-catalytic ribozymes and mobile genetic elements found within the genes of all three domains of life. Ribozyme activity (e.g., self-splicing) can occur under high-salt conditions in vitro. However, assistance from proteins is required for in vivo splicing. In contrast to group I introns, intron excision occurs in the absence of GTP and involves the formation of a lariat, with an A-residue branchpoint strongly resembling that found in lariats formed during splicing of nuclear pre-mRNA. It is hypothesized that pre-mRNA splicing (see spliceosome) may have evolved from group II introns, due to the similar catalytic mechanism as well as the structural similarity of the Group II Domain V substructure to the U6/U2 extended snRNA. Finally, their ability to extended snRNA. Finally, their ability to
|
| rdfs:label |
Group II intron
|
