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GL261（Glioma 261）是一種常用於科研用途的小鼠神經膠質瘤細胞系，最初是通過顱內注射甲基膽甾醇，然後將腫瘤片段連續地顱內移植和皮下移植到體內誘導的。1990年代中期，已有多個研究小組從腫瘤中建立了永生細胞系。
, Glioma 261 (GL261) is a frequently used mu … Glioma 261 (GL261) is a frequently used murine glioma model. It was induced via intracranial injection of methylcholanthrene followed by serial intracranial and subcutaneous transplantations of tumor fragments into syngeneic C57BL/6 mice. By the mid-1990s, multiple groups had established a permanent cell line from the tumor. GL261 tumors resemble ependymoblastomas on histology but show many characteristics of glioblastoma phenotypes. They contain activating mutations of the K-ras as well as mutations of p53, resulting in high expression of c-myc. GL261 tumors also highly express MHC I, explaining their partial immunogenicity and have limited expression of MHC II, B7-1, and B7-2. The tumors are invasive, are not known to be metastatic, and do not spontaneously regress. Other immunocompetent murine models used to study GBM include GL26, CT-2A, SMA-560, and 4C8.GBM include GL26, CT-2A, SMA-560, and 4C8.
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| rdfs:comment |
GL261（Glioma 261）是一種常用於科研用途的小鼠神經膠質瘤細胞系，最初是通過顱內注射甲基膽甾醇，然後將腫瘤片段連續地顱內移植和皮下移植到體內誘導的。1990年代中期，已有多個研究小組從腫瘤中建立了永生細胞系。
, Glioma 261 (GL261) is a frequently used mu … Glioma 261 (GL261) is a frequently used murine glioma model. It was induced via intracranial injection of methylcholanthrene followed by serial intracranial and subcutaneous transplantations of tumor fragments into syngeneic C57BL/6 mice. By the mid-1990s, multiple groups had established a permanent cell line from the tumor. Other immunocompetent murine models used to study GBM include GL26, CT-2A, SMA-560, and 4C8.GBM include GL26, CT-2A, SMA-560, and 4C8.
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GL261
, Glioma 261
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