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Апротини́н (англ. Aprotinin, CAS-код 9087- … Апротини́н (англ. Aprotinin, CAS-код 9087-70-1, брутто-формула C284H432N84O79S7) — лекарственное средство, антиферментный препарат, получаемый из органов крупного рогатого скота (легкие и др.), поливалентный ингибитор протеаз. Торговое наименование — Аптотекс (лат. Aptotex). Активность апротинина выражают в различных единицах: КИЕ — калликреин инактивирующие единицы; Ph.Eur.U — трипсин инактивирующие единицы Европейской Фармакопеи, 1 Ph.Eur.U соответствует 1800 КИЕ; АТрЕ — антитрипсиновые единицы, 1 АТрЕ соответствует 1,33 КИЕ; ЕД — единицы действия фермента по Государственной Фармакопее СССР. Разработчиком лекарства апротинин позиционируется как средство для лечения панкреатита и . Однако, в данное время показания к применению апротинина и его аналогов существенно изменены. Так, он исключен из рекомендаций по лечению острого (и, тем более — хронического) панкреатита как не подтвердивший эффективности по критериям доказательной медицины не только на Западе (США и Европа), но и в России. При этом он разрешен в России для применения в отношении таких показаний, как:
* абстинентный синдром при опийной наркомании;
* лечение опиатного абстинентного синдрома как самостоятельно, так и в составе комплексной терапии;
* болезненная симптоматика, включая «нестерпимые боли», мышечные боли, синусопатии, ознобы, гипертермию, потливость, анорексию, бессонницу, дисфорию, ипохондричность.ию, бессонницу, дисфорию, ипохондричность.
, Aprotynina – inhibitor proteaz serynowo-tr … Aprotynina – inhibitor proteaz serynowo-treoninowych. Jest globularnym polipeptydem o długości 58 aminokwasów, którego struktura przestrzenna jest stabilizowana przez trzy mostki dwusiarczkowe. Aprotynina pozyskiwana z płuc wołowych jest stosowana w medycynie jako środek zmniejszający krwawienia przy skomplikowanych operacjach chirurgicznych. Aprotyninę stosuje się także w biochemii i biologii molekularnej do ochrony białek przed strawieniem przez proteazy serynowo-treoninowe. Apronityna jest składnikiem żelu stomatologicznego Trascodent.dnikiem żelu stomatologicznego Trascodent.
, Aprotinina è un principio attivo, un inibi … Aprotinina è un principio attivo, un inibitore della proteasi tripsina pancreatica bovina, una proteina antifibrinolitica che inibisce la tripsina e gli enzimi proteolitici correlati. Il farmaco ha il nome commerciale di Trasylol ed era somministrato per via parenterale per ridurre il sanguinamento durante interventi chirurgici complessi in modo tale da ridurre la necessità di trasfusioni di sangue e i danni agli organi dovuti all'ipotensione. Il farmaco rallenta la fibrinolisi, il processo che porta alla rottura dei coaguli di sangue. Il farmaco è stato temporaneamente ritirato in tutto il mondo nel 2007 a causa di alcuni studi che suggeriscono che il suo uso aumenta il rischio di complicanze e morte. Le vendite sono state sospese a maggio 2008, ad eccezione dell'uso per motivi di ricerca. Nel febbraio 2012 il comitato scientifico dell'Agenzia europea per i medicinali (EMA) ha raccomandato di revocare la sospensione.a raccomandato di revocare la sospensione.
, The drug aprotinin (Trasylol, previously B … The drug aprotinin (Trasylol, previously Bayer and now Nordic Group pharmaceuticals), is a small protein bovine pancreatic trypsin inhibitor (BPTI), or basic trypsin inhibitor of bovine pancreas, which is an antifibrinolytic molecule that inhibits trypsin and related proteolytic enzymes. Under the trade name Trasylol, aprotinin was used as a medication administered by injection to reduce bleeding during complex surgery, such as heart and liver surgery. Its main effect is the slowing down of fibrinolysis, the process that leads to the breakdown of blood clots. The aim in its use was to decrease the need for blood transfusions during surgery, as well as end-organ damage due to hypotension (low blood pressure) as a result of marked blood loss. The drug was temporarily withdrawn worldwide in 2007 after studies suggested that its use increased the risk of complications or death; this was confirmed by follow-up studies. Trasylol sales were suspended in May 2008, except for very restricted research use. In February 2012 the European Medicines Agency (EMA) scientific committee reverted its previous standpoint regarding aprotinin, and has recommended that the suspension be lifted. Nordic became distributor of aprotinin in 2012.c became distributor of aprotinin in 2012.
, Aprotinin (pankreatischer Trypsin-Inhibito … Aprotinin (pankreatischer Trypsin-Inhibitor) ist ein natürliches Polypeptid und ein Proteaseinhibitor. Das Aprotinin des Hausrinds wird in der Humanmedizin zur Reduktion der Blutungsneigung eingesetzt. Aprotinin wird z. B. bei Operationen am offenen Herzen oder in der Leberchirurgie verabreicht, um den Blutverlust zu reduzieren und den Bedarf an Bluttransfusionen zu minimieren. Im November 2007 wurde es aufgrund von Hinweisen auf erhöhte Nebenwirkungen vorübergehend weltweit vom Markt genommen. Es wird aus Lungengewebe von Kühen extrahiert. Der Trypsin-Inhibitor wurde 1930 durch den Münchner Arbeitskreis um Ernst Kurt Frey, H. Kraut und E. Werle entdeckt und 1959 von Bayer patentiert. Aprotinin besteht aus 58 Aminosäuren. Aprotinin ist ein Proteaseinhibitor, dessen Hauptwirkung in einer Hemmung der Serinprotease Plasmin besteht, wodurch der Abbau geronnenen Blutes (Fibrinolyse) verlangsamt wird.nen Blutes (Fibrinolyse) verlangsamt wird.
, El Aprotinina es un agente hemostático que inhibe las proteasas
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The drug aprotinin (Trasylol, previously B … The drug aprotinin (Trasylol, previously Bayer and now Nordic Group pharmaceuticals), is a small protein bovine pancreatic trypsin inhibitor (BPTI), or basic trypsin inhibitor of bovine pancreas, which is an antifibrinolytic molecule that inhibits trypsin and related proteolytic enzymes. Under the trade name Trasylol, aprotinin was used as a medication administered by injection to reduce bleeding during complex surgery, such as heart and liver surgery. Its main effect is the slowing down of fibrinolysis, the process that leads to the breakdown of blood clots. The aim in its use was to decrease the need for blood transfusions during surgery, as well as end-organ damage due to hypotension (low blood pressure) as a result of marked blood loss. The drug was temporarily withdrawn worldwide in 2g was temporarily withdrawn worldwide in 2
, Aprotinina è un principio attivo, un inibi … Aprotinina è un principio attivo, un inibitore della proteasi tripsina pancreatica bovina, una proteina antifibrinolitica che inibisce la tripsina e gli enzimi proteolitici correlati. Il farmaco ha il nome commerciale di Trasylol ed era somministrato per via parenterale per ridurre il sanguinamento durante interventi chirurgici complessi in modo tale da ridurre la necessità di trasfusioni di sangue e i danni agli organi dovuti all'ipotensione. Il farmaco rallenta la fibrinolisi, il processo che porta alla rottura dei coaguli di sangue. Il farmaco è stato temporaneamente ritirato in tutto il mondo nel 2007 a causa di alcuni studi che suggeriscono che il suo uso aumenta il rischio di complicanze e morte. Le vendite sono state sospese a maggio 2008, ad eccezione dell'uso per motivi di ricercad eccezione dell'uso per motivi di ricerca
, Апротини́н (англ. Aprotinin, CAS-код 9087- … Апротини́н (англ. Aprotinin, CAS-код 9087-70-1, брутто-формула C284H432N84O79S7) — лекарственное средство, антиферментный препарат, получаемый из органов крупного рогатого скота (легкие и др.), поливалентный ингибитор протеаз. Торговое наименование — Аптотекс (лат. Aptotex). Активность апротинина выражают в различных единицах: КИЕ — калликреин инактивирующие единицы; Ph.Eur.U — трипсин инактивирующие единицы Европейской Фармакопеи, 1 Ph.Eur.U соответствует 1800 КИЕ; АТрЕ — антитрипсиновые единицы, 1 АТрЕ соответствует 1,33 КИЕ; ЕД — единицы действия фермента по Государственной Фармакопее СССР.рмента по Государственной Фармакопее СССР.
, Aprotinin (pankreatischer Trypsin-Inhibito … Aprotinin (pankreatischer Trypsin-Inhibitor) ist ein natürliches Polypeptid und ein Proteaseinhibitor. Das Aprotinin des Hausrinds wird in der Humanmedizin zur Reduktion der Blutungsneigung eingesetzt. Aprotinin wird z. B. bei Operationen am offenen Herzen oder in der Leberchirurgie verabreicht, um den Blutverlust zu reduzieren und den Bedarf an Bluttransfusionen zu minimieren. Im November 2007 wurde es aufgrund von Hinweisen auf erhöhte Nebenwirkungen vorübergehend weltweit vom Markt genommen.vorübergehend weltweit vom Markt genommen.
, El Aprotinina es un agente hemostático que inhibe las proteasas
, Aprotynina – inhibitor proteaz serynowo-tr … Aprotynina – inhibitor proteaz serynowo-treoninowych. Jest globularnym polipeptydem o długości 58 aminokwasów, którego struktura przestrzenna jest stabilizowana przez trzy mostki dwusiarczkowe. Aprotynina pozyskiwana z płuc wołowych jest stosowana w medycynie jako środek zmniejszający krwawienia przy skomplikowanych operacjach chirurgicznych. Aprotyninę stosuje się także w biochemii i biologii molekularnej do ochrony białek przed strawieniem przez proteazy serynowo-treoninowe. Apronityna jest składnikiem żelu stomatologicznego Trascodent.dnikiem żelu stomatologicznego Trascodent.
|
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, Aprotynina
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