| http://dbpedia.org/ontology/abstract
|
Delta hexatoxin Hv1 (δ-HXTX-Hv1a, Versutox … Delta hexatoxin Hv1 (δ-HXTX-Hv1a, Versutoxin, or Versutotoxin, formerly known as Delta atracotoxin Hv1 and δ-ACTX-Hv1a) is a neurotoxic component found in the venom of the Australian funnel web spider (Atrax robustus). Delta hexatoxin Hv1 can result in fatality for primates, by downregulating the inactivation of voltage gated sodium ion channels (VGSCs) found in motor neurons. The structure of versutoxin contains a central beta region with a cystine knot motif, commonly found in other neurotoxic polypeptides, but not found in sea anemone or alpha-scorpion toxins despite their similar effects in terms of sodium channel modulation.cts in terms of sodium channel modulation.
|
| http://dbpedia.org/ontology/symbol
|
δ-HXTX-Hv1a
|
| http://dbpedia.org/ontology/thumbnail
|
http://commons.wikimedia.org/wiki/Special:FilePath/3D_Model_of_1vtx.png?width=300 +
|
| http://dbpedia.org/ontology/wikiPageID
|
69140680
|
| http://dbpedia.org/ontology/wikiPageLength
|
9565
|
| http://dbpedia.org/ontology/wikiPageRevisionID
|
1119452938
|
| http://dbpedia.org/ontology/wikiPageWikiLink
|
http://dbpedia.org/resource/Atracotoxin +
, http://dbpedia.org/resource/Asparagine +
, http://dbpedia.org/resource/Category:Spider_toxins +
, http://dbpedia.org/resource/Category:Neurotoxins +
, http://dbpedia.org/resource/Polypeptide +
, http://dbpedia.org/resource/Sucrose_gap +
, http://dbpedia.org/resource/Australian_funnel-web_spider +
, http://dbpedia.org/resource/Gurmarin +
, http://dbpedia.org/resource/Tryptophan +
, http://dbpedia.org/resource/Neuron +
, http://dbpedia.org/resource/Recombinant_DNA +
, http://dbpedia.org/resource/C-terminus +
, http://dbpedia.org/resource/Methionine +
, http://dbpedia.org/resource/Serine +
, http://dbpedia.org/resource/Neurotoxin +
, http://dbpedia.org/resource/Dorsal_unpaired_median +
, http://dbpedia.org/resource/Nemertide_%CE%B1-1 +
, http://dbpedia.org/resource/Sea_anemone_neurotoxin +
, http://dbpedia.org/resource/Lysine +
, http://dbpedia.org/resource/Biopesticide +
, http://dbpedia.org/resource/Glutamine +
, http://dbpedia.org/resource/Dorsal_root_ganglion +
, http://dbpedia.org/resource/Down-regulating +
, http://dbpedia.org/resource/Beta_turn +
, http://dbpedia.org/resource/Category:Sodium_channel_blockers +
, http://dbpedia.org/resource/Inhibitor_cystine_knot +
, http://dbpedia.org/resource/Isoleucine +
, http://dbpedia.org/resource/Biological_activity +
, http://dbpedia.org/resource/Disulphide_bond +
, http://dbpedia.org/resource/Sodium_channel_inhibitor +
, http://dbpedia.org/resource/Anti-parallel_%CE%B2_sheet +
, http://dbpedia.org/resource/Glycine +
, http://dbpedia.org/resource/310_helix +
, http://dbpedia.org/resource/Valine +
, http://dbpedia.org/resource/Voltage_gated_sodium_channels +
, http://dbpedia.org/resource/Scorpion_toxin +
, http://dbpedia.org/resource/Cysteine +
, http://dbpedia.org/resource/Voltage-gated_sodium_channel +
|
| http://dbpedia.org/property/caption
|
3
|
| http://dbpedia.org/property/interpro
|
IPR008017
|
| http://dbpedia.org/property/name
|
Delta Hexatoxin Hv1a
|
| http://dbpedia.org/property/opmFamily
|
112
|
| http://dbpedia.org/property/opmProtein
|
1
|
| http://dbpedia.org/property/pfam
|
PF05353
|
| http://dbpedia.org/property/symbol
|
δ-HXTX-Hv1a
|
| http://dbpedia.org/property/wikiPageUsesTemplate
|
http://dbpedia.org/resource/Template:Channelergics +
, http://dbpedia.org/resource/Template:Center +
, http://dbpedia.org/resource/Template:Pfam_box +
, http://dbpedia.org/resource/Template:Reflist +
|
| http://purl.org/dc/terms/subject
|
http://dbpedia.org/resource/Category:Spider_toxins +
, http://dbpedia.org/resource/Category:Sodium_channel_blockers +
, http://dbpedia.org/resource/Category:Neurotoxins +
|
| http://www.w3.org/ns/prov#wasDerivedFrom
|
http://en.wikipedia.org/wiki/Versutoxin?oldid=1119452938&ns=0 +
|
| http://xmlns.com/foaf/0.1/depiction
|
http://commons.wikimedia.org/wiki/Special:FilePath/3D_Model_of_1vtx.png +
|
| http://xmlns.com/foaf/0.1/isPrimaryTopicOf
|
http://en.wikipedia.org/wiki/Versutoxin +
|
| owl:sameAs |
http://www.wikidata.org/entity/Q109371553 +
, https://global.dbpedia.org/id/G6aDr +
, http://dbpedia.org/resource/Versutoxin +
|
| rdf:type |
http://dbpedia.org/ontology/Biomolecule +
, http://dbpedia.org/ontology/Protein +
, http://www.wikidata.org/entity/Q8054 +
, http://www.wikidata.org/entity/Q206229 +
|
| rdfs:comment |
Delta hexatoxin Hv1 (δ-HXTX-Hv1a, Versutox … Delta hexatoxin Hv1 (δ-HXTX-Hv1a, Versutoxin, or Versutotoxin, formerly known as Delta atracotoxin Hv1 and δ-ACTX-Hv1a) is a neurotoxic component found in the venom of the Australian funnel web spider (Atrax robustus). Delta hexatoxin Hv1 can result in fatality for primates, by downregulating the inactivation of voltage gated sodium ion channels (VGSCs) found in motor neurons.n channels (VGSCs) found in motor neurons.
|
| rdfs:label |
Versutoxin
|
