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The enzyme UDP-glucose 4-epimerase (EC 5.1 … The enzyme UDP-glucose 4-epimerase (EC 5.1.3.2), also known as UDP-galactose 4-epimerase or GALE, is a homodimeric epimerase found in bacterial, fungal, plant, and mammalian cells. This enzyme performs the final step in the Leloir pathway of galactose metabolism, catalyzing the reversible conversion of UDP-galactose to UDP-glucose. GALE tightly binds nicotinamide adenine dinucleotide (NAD+), a co-factor required for catalytic activity. Additionally, human and some bacterial GALE isoforms reversibly catalyze the formation of UDP-N-acetylgalactosamine (UDP-GalNAc) from UDP-N-acetylglucosamine (UDP-GlcNAc) in the presence of NAD+, an initial step in glycoprotein or glycolipid synthesis.p in glycoprotein or glycolipid synthesis.
, L'UDP-glucose 4-épimérase, ou UDP-galactos … L'UDP-glucose 4-épimérase, ou UDP-galactose 4-épimérase (GALE), est une épimérase homodimérique présente chez les bactéries, les mycètes, les plantes et les mammifères, qui catalyse la réaction : UDP-glucose UDP-galactose. Cette enzyme intervient à l'étape finale de la voie de Leloir de dégradation du galactose. Elle requiert du NAD+ comme cofacteur. Chez l'homme et chez certaines bactéries, cette enzyme est également capable d'agir sur l'UDP-N-acétylglucosamine pour former de l' en présence de NAD+, étape initiale de la biosynthèse de glycoprotéines et de glycolipides.hèse de glycoprotéines et de glycolipides.
, UDP-ガラクトース-4-エピメラーゼ（英：UDP-galactose-4-epimerase、GALE、EC 5.1.3.2）またはUDP-グルコース-4-エピメラーゼは、ガラクトース血症のタイプ3に関連する酵素である。この酵素はUDP-グルコースをUDP-ガラクトースへ転換する。
, UDP-Glucose-4-Epimerase (Gen: GALE), auch … UDP-Glucose-4-Epimerase (Gen: GALE), auch UDP-Galactose-4-Epimerase, ist das Enzym, das die Umlagerung von zu UDP-Glucose und umgekehrt katalysiert. Diese Reaktion ist ein Teilschritt in der Verwertung von Galactose in vielen Lebewesen. Mutationen im GALE-Gen können zum Mangel an Epimerase und dieser zu Galaktosämie Typ 3 führen.e und dieser zu Galaktosämie Typ 3 führen.
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Human GALE bound to NAD+ and UDP-GlcNAc, with N- and C-terminal domains highlighted. Asn 207 contorts to accommodate UDP-GlcNAc within the active site.
, H. sapiens UDP-glucose 4-epimerase homodimer bound to NADH and UDP-glucose. Domains: N-terminal and C-terminal.
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| rdfs:comment |
L'UDP-glucose 4-épimérase, ou UDP-galactos … L'UDP-glucose 4-épimérase, ou UDP-galactose 4-épimérase (GALE), est une épimérase homodimérique présente chez les bactéries, les mycètes, les plantes et les mammifères, qui catalyse la réaction : UDP-glucose UDP-galactose. Cette enzyme intervient à l'étape finale de la voie de Leloir de dégradation du galactose. Elle requiert du NAD+ comme cofacteur. Chez l'homme et chez certaines bactéries, cette enzyme est également capable d'agir sur l'UDP-N-acétylglucosamine pour former de l' en présence de NAD+, étape initiale de la biosynthèse de glycoprotéines et de glycolipides.hèse de glycoprotéines et de glycolipides.
, UDP-ガラクトース-4-エピメラーゼ（英：UDP-galactose-4-epimerase、GALE、EC 5.1.3.2）またはUDP-グルコース-4-エピメラーゼは、ガラクトース血症のタイプ3に関連する酵素である。この酵素はUDP-グルコースをUDP-ガラクトースへ転換する。
, UDP-Glucose-4-Epimerase (Gen: GALE), auch … UDP-Glucose-4-Epimerase (Gen: GALE), auch UDP-Galactose-4-Epimerase, ist das Enzym, das die Umlagerung von zu UDP-Glucose und umgekehrt katalysiert. Diese Reaktion ist ein Teilschritt in der Verwertung von Galactose in vielen Lebewesen. Mutationen im GALE-Gen können zum Mangel an Epimerase und dieser zu Galaktosämie Typ 3 führen.e und dieser zu Galaktosämie Typ 3 führen.
, The enzyme UDP-glucose 4-epimerase (EC 5.1 … The enzyme UDP-glucose 4-epimerase (EC 5.1.3.2), also known as UDP-galactose 4-epimerase or GALE, is a homodimeric epimerase found in bacterial, fungal, plant, and mammalian cells. This enzyme performs the final step in the Leloir pathway of galactose metabolism, catalyzing the reversible conversion of UDP-galactose to UDP-glucose. GALE tightly binds nicotinamide adenine dinucleotide (NAD+), a co-factor required for catalytic activity.co-factor required for catalytic activity.
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UDP-Glucose-4-Epimerase
, UDP-ガラクトース-4-エピメラーゼ
, UDP-glucose 4-epimerase
, UDP-glucose 4-épimérase
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