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تيلينزيبين (بالإنجليزية: Telenzepine) هو مضاد انتقائي مسكاريني 1 المُستخدمة في علاج القُرحة الهضمية.
, Telenzepine is a thienobenzodiazepine acti … Telenzepine is a thienobenzodiazepine acting as selective M1 antimuscarinic. It is used in the treatment of peptic ulcers. Telenzepine is atropisomeric, in other words the molecule has a stereogenic C–N-axis. In neutral aqueous solution it displays a half-life for racemization of the order of 1000 years. The enantiomers have been resolved. The activity is related to the (+)-isomer which is about 500-fold more active than the (–)-isomer at muscarinic receptors in the rat cerebral cortex.inic receptors in the rat cerebral cortex.
, La télenzépine est une substance chimique … La télenzépine est une substance chimique qui est un antimuscarinique M1 sélectif utilisé dans le traitement des ulcères gastro-duodénaux. La télenzépine est atropoisomérique car la molécule a une liaison simple C-N dont la rotation est bloquée et constitue donc un axe stéréogène. En solution aqueuse neutre, elle affiche une demi-vie pour la racémisation de l'ordre de 1000 ans. Les énantiomères ont été résolus. L'isomère dextrogyre (+) est environ 500 fois plus actif que l'isomère lévogyre (-) au niveau des récepteurs muscariniques dans le cortex cérébral du rat.cariniques dans le cortex cérébral du rat.
, La telenzepina è una tienobenzodiazepina c … La telenzepina è una tienobenzodiazepina che agisce come antimuscarinico M1 selettivo. È usato nel trattamento delle ulcere peptiche. La telenzepina è atropisomerica, in altre parole la molecola ha un asse C–N stereogenico. In soluzione acquosa neutra mostra un'emivita per racemizzazione dell'ordine di 1000 anni. Gli enantiomeri sono stati risolti. L'attività è correlata all'isomero (+) che è circa 500 volte più attivo dell'isomero (–) sui recettori muscarinici nella corteccia cerebrale del rattorinici nella corteccia cerebrale del ratto
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| rdfs:comment |
Telenzepine is a thienobenzodiazepine acti … Telenzepine is a thienobenzodiazepine acting as selective M1 antimuscarinic. It is used in the treatment of peptic ulcers. Telenzepine is atropisomeric, in other words the molecule has a stereogenic C–N-axis. In neutral aqueous solution it displays a half-life for racemization of the order of 1000 years. The enantiomers have been resolved. The activity is related to the (+)-isomer which is about 500-fold more active than the (–)-isomer at muscarinic receptors in the rat cerebral cortex.inic receptors in the rat cerebral cortex.
, La télenzépine est une substance chimique … La télenzépine est une substance chimique qui est un antimuscarinique M1 sélectif utilisé dans le traitement des ulcères gastro-duodénaux. La télenzépine est atropoisomérique car la molécule a une liaison simple C-N dont la rotation est bloquée et constitue donc un axe stéréogène. En solution aqueuse neutre, elle affiche une demi-vie pour la racémisation de l'ordre de 1000 ans. Les énantiomères ont été résolus. L'isomère dextrogyre (+) est environ 500 fois plus actif que l'isomère lévogyre (-) au niveau des récepteurs muscariniques dans le cortex cérébral du rat.cariniques dans le cortex cérébral du rat.
, La telenzepina è una tienobenzodiazepina c … La telenzepina è una tienobenzodiazepina che agisce come antimuscarinico M1 selettivo. È usato nel trattamento delle ulcere peptiche. La telenzepina è atropisomerica, in altre parole la molecola ha un asse C–N stereogenico. In soluzione acquosa neutra mostra un'emivita per racemizzazione dell'ordine di 1000 anni. Gli enantiomeri sono stati risolti. L'attività è correlata all'isomero (+) che è circa 500 volte più attivo dell'isomero (–) sui recettori muscarinici nella corteccia cerebrale del rattorinici nella corteccia cerebrale del ratto
, تيلينزيبين (بالإنجليزية: Telenzepine) هو مضاد انتقائي مسكاريني 1 المُستخدمة في علاج القُرحة الهضمية.
|
| rdfs:label |
Telenzepine
, Telenzepina
, Télenzépine
, تيلينزيبين
|
