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Stanford V — режим химиотерапии, разработа … Stanford V — режим химиотерапии, разработанный в 1988 году Стэнфордским Центром по изучению рака при Стэнфордском медицинском университете и предназначенный для лечения лимфогранулематоза, как первая линия терапии. Целью его разработки было добиться не худшей частоты полных ремиссий, чем у режимов MOPP, COPP и ABVD, и в то же время уменьшить частоту острых и отсроченных побочных токсических явлений, частоту повреждений лёгких блеомицином, частоту развития вторичных опухолей и частоту утраты фертильности по сравнению с этими режимами.ертильности по сравнению с этими режимами.
, Stanford V (usually spoken as Stanford Fiv … Stanford V (usually spoken as Stanford Five), is a chemotherapy regimen (with accompanying Radiation therapy) intended as a first-line treatment for Hodgkin lymphoma. The regimen was developed in 1988, with the objective of maintaining a high remission rate while reducing the incidence of acute and long term toxicity, pulmonary damage, and sterility observed in alternative treatment regimens such as ABVD. The chemical agents used are:
* A mustard derivative such as cyclophosphamide, chlormethine or ifosfamide
* Doxorubicin, an anti-tumor antibiotic
* Vinblastine, an alkaloid cell toxin
* Vincristine, another alkaloid cell toxin
* Bleomycin, another anti-tumor antibiotic
* Etoposide, a DNA toxin
* Prednisone, a corticosteroid Drug Regimen The chemotherapy part of Stanford V treatment can last anywhere from 8 to 12 weeks, depending on the staging of the disease. In many cases, this is followed by radiation therapy for anywhere from 2 to 6 weeks to the affected areas of the body. Stanford V is a more rigorously administered form of chemotherapy, with treatments roughly twice as fast as those of other Hodgkin lymphoma treatments. However, in a randomized controlled study, Stanford V was inferior to ABVD. This study has been criticized for not adhering to the proper Stanford V protocol. Specifically, the radiation therapy component following chemotherapy was not properly administered in the Italian study. A retrospective study from the Memorial Sloan-Kettering Cancer Center displayed results similar to the Stanford Cancer Center's own experience. The study concluded that, "Stanford V with appropriate radiotherapy is a highly effective regimen for locally extensive and advanced HL."en for locally extensive and advanced HL."
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Stanford V — режим химиотерапии, разработа … Stanford V — режим химиотерапии, разработанный в 1988 году Стэнфордским Центром по изучению рака при Стэнфордском медицинском университете и предназначенный для лечения лимфогранулематоза, как первая линия терапии. Целью его разработки было добиться не худшей частоты полных ремиссий, чем у режимов MOPP, COPP и ABVD, и в то же время уменьшить частоту острых и отсроченных побочных токсических явлений, частоту повреждений лёгких блеомицином, частоту развития вторичных опухолей и частоту утраты фертильности по сравнению с этими режимами.ертильности по сравнению с этими режимами.
, Stanford V (usually spoken as Stanford Fiv … Stanford V (usually spoken as Stanford Five), is a chemotherapy regimen (with accompanying Radiation therapy) intended as a first-line treatment for Hodgkin lymphoma. The regimen was developed in 1988, with the objective of maintaining a high remission rate while reducing the incidence of acute and long term toxicity, pulmonary damage, and sterility observed in alternative treatment regimens such as ABVD. The chemical agents used are: Drug RegimenThe chemical agents used are: Drug Regimen
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Stanford V
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