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A spindle poison, also known as a spindle … A spindle poison, also known as a spindle toxin, is a poison that disrupts cell division by affecting the protein threads that connect the centromere regions of chromosomes, known as spindles. Spindle poisons effectively cease the production of new cells by interrupting the mitosis phase of cell division at the spindle assembly checkpoint (SAC). However, as numerous and varied as they are, spindle poisons are not yet 100% effective at ending the formation of tumors (neoplasms). Although not 100% effective, substantive therapeutic efficacy has been found in these types of chemotherapeutic treatments. The mitotic spindle is composed of microtubules (polymerized tubulin) that aid, along with regulatory proteins, each other in the activity of appropriately segregating replicated chromosomes. Certain compounds affecting the mitotic spindle have proven highly effective against solid tumors and hematological malignancies. Two specific families of antimitotic agents — vinca alkaloids and taxanes — interrupt the cell’s division by the agitation of microtubule dynamics. The vinca alkaloids work by causing the inhibition of the polymerization of tubulin into microtubules, resulting in the G2/M arrest within the cell cycle and eventually cell death. In contrast, the taxanes arrest the mitotic cell cycle by stabilizing microtubules against depolymerization. Even though numerous other spindle proteins exist that could be the target of novel chemotherapeutics, tubulin-binding agents are the only types in clinical use. Agents that affect the motor protein kinesin are beginning to enter clinical trials. Another type, paclitaxel, acts by attaching to tubulin within existing microtubules. Next, it stabilizes the polymer.otubules. Next, it stabilizes the polymer.
, I farmaci antimitotici, noti anche come to … I farmaci antimitotici, noti anche come tossine antimitotiche, sono veleni che distruggono la divisione cellulare influenzando i fili proteici che collegano le regioni centromeriche dei cromosomi. Tali veleni bloccano in modo efficace la produzione di nuove cellule interrompendo la fase di mitosi della divisione cellulare. Purtroppo, tali farmaci, sono numerosi e vari, e dovrebbero essere efficaci al 100% per porre fine alla formazione dei tumori (neoplasie). Sebbene non efficaci al 100%, è stata rilevata una certa efficacia terapeutica in questi trattamenti chemioterapici. Il fuso mitotico è composto da microtubuli (tubulina polimerizzata) che entrano, insieme a proteine regolatrici, nell'attività di segregare i cromosomi replicati. Alcuni composti che influenzano il fuso mitotico si sono dimostrati molto efficaci contro i tumori solidi e le neoplasie ematologiche. Due famiglie specifiche di agenti antimitotici, alcaloidi della vinca e taxani, interrompono la divisione della cellula per la modificazione della dinamica dei microtubuli. Gli alcaloidi della vinca agiscono provocando l'inibizione della polimerizzazione della tubulina in microtubuli, conseguente all'arresto del G2/M all'interno del ciclo cellulare ed eventualmente la morte cellulare. Al contrario, i taxani arrestano il ciclo cellulare mitotico, stabilizzando i microtubuli inibendo la depolimerizzazione. Anche se numerose esistono altre proteine, che potrebbe essere il bersaglio di nuovi chemioterapici, gli agenti sulla tubulina sono gli unici tipi nell'uso clinico. Gli agenti che influenzano la chinesina motore stanno cominciando ad entrare in studi clinici. Il taxolo, agisce legandosi alla tubulina all'interno dei microtubuli esistenti, stabilizzando il polimero.buli esistenti, stabilizzando il polimero.
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| rdfs:comment |
I farmaci antimitotici, noti anche come to … I farmaci antimitotici, noti anche come tossine antimitotiche, sono veleni che distruggono la divisione cellulare influenzando i fili proteici che collegano le regioni centromeriche dei cromosomi. Tali veleni bloccano in modo efficace la produzione di nuove cellule interrompendo la fase di mitosi della divisione cellulare. Purtroppo, tali farmaci, sono numerosi e vari, e dovrebbero essere efficaci al 100% per porre fine alla formazione dei tumori (neoplasie). Sebbene non efficaci al 100%, è stata rilevata una certa efficacia terapeutica in questi trattamenti chemioterapici. Il fuso mitotico è composto da microtubuli (tubulina polimerizzata) che entrano, insieme a proteine regolatrici, nell'attività di segregare i cromosomi replicati. Alcuni composti che influenzano il fuso mitotico si sonoi che influenzano il fuso mitotico si sono
, A spindle poison, also known as a spindle … A spindle poison, also known as a spindle toxin, is a poison that disrupts cell division by affecting the protein threads that connect the centromere regions of chromosomes, known as spindles. Spindle poisons effectively cease the production of new cells by interrupting the mitosis phase of cell division at the spindle assembly checkpoint (SAC). However, as numerous and varied as they are, spindle poisons are not yet 100% effective at ending the formation of tumors (neoplasms). Although not 100% effective, substantive therapeutic efficacy has been found in these types of chemotherapeutic treatments. The mitotic spindle is composed of microtubules (polymerized tubulin) that aid, along with regulatory proteins, each other in the activity of appropriately segregating replicated chromosomes. Ctely segregating replicated chromosomes. C
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Farmaci antimitotici
, Spindle poison
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