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Selectivity factor is a quantifiable measu … Selectivity factor is a quantifiable measure of how efficient an antibiotic is during the process of gene selection. It measures of the capacity an antibiotic to select for transfected (resistant) cells that contain a selectable marker, while killing untransfected (sensitive) cells that do not contain a selectable marker. A selectivity factor higher than 10 is optimal. This means the concentration of antibiotic is sufficient to kill untransfected cells but not toxic enough to kill transfected cells. A selectivity factor lower than 10 means the concentration of antibiotic needed for selection is too close to the toxic concentration for the transfected cells. As a result, fewer transfected cells survive and more untransfected cells survive. In this case an alternative antibiotic should be considered.ternative antibiotic should be considered.
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| rdfs:comment |
Selectivity factor is a quantifiable measu … Selectivity factor is a quantifiable measure of how efficient an antibiotic is during the process of gene selection. It measures of the capacity an antibiotic to select for transfected (resistant) cells that contain a selectable marker, while killing untransfected (sensitive) cells that do not contain a selectable marker. A selectivity factor higher than 10 is optimal. This means the concentration of antibiotic is sufficient to kill untransfected cells but not toxic enough to kill transfected cells. A selectivity factor lower than 10 means the concentration of antibiotic needed for selection is too close to the toxic concentration for the transfected cells. As a result, fewer transfected cells survive and more untransfected cells survive. In this case an alternative antibiotic should be coase an alternative antibiotic should be co
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| rdfs:label |
Selectivity factor
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