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Le rocaglamide est un produit naturel anti … Le rocaglamide est un produit naturel anticancéreux qui appartient à la famille des flavaglines. Ce composé a été isolé en 1982 par King et collaborateurs du Centre National de Défense Médicale de Taiwan, en se basant sur sa forte activité antileucémique. Comme d’autres flavaglines, le rocaglamide présente de puissantes activités insecticides, antifongiques, anti-inflammatoires, et surtout anticancéreuses. Le rocaglamide a été synthétisé pour la première fois par Barry Trost en 1990. Bien que d’autres synthèses aient été décrites par la suite, celle développée par Trost reste la seule qui permette de préparer le rocaglamide de manière énantiospécifique. rocaglamide de manière énantiospécifique.
, Rocaglamide is a natural product which bel … Rocaglamide is a natural product which belongs to a class of molecules called flavaglines. This compound was isolated in 1982 by King, Ming-Lu (金明儒) and colleagues based on its antileukemic activity. The name of Rocaglamide is named from two parts: Roc- and aglamide. Roc- means Republic of China(中華民國), the place in which this product isolated; aglamide indicates this product is isolated from Large-leaved Aglaia (Latin: ). Like other flavaglines, rocaglamide displays potent insecticidal, antifungal, anti-inflammatory and anticancer activities. Rocaglamide A (RocA) inhibits eukaryotic translation initiation by binding to the translation initiation factor eIF4A and converting it into a translational repressor. Rocaglamide was first synthesized by Barry Trost in 1990. Although other syntheses have been described since, Trost’s remains the only one to afford rocaglamide in an enantio-specific manner.rocaglamide in an enantio-specific manner.
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(1R,2R,3S,3aR,8bS)-1,8b-Dihydroxy-6,8-dimethoxy-3a-(4-methoxyphenyl)-N,N-dimethyl-3-phenyl-2,3,3a,8b-tetrahydro-1H-cyclopenta[b][1]benzofuran-2-carboxamide
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Le rocaglamide est un produit naturel anti … Le rocaglamide est un produit naturel anticancéreux qui appartient à la famille des flavaglines. Ce composé a été isolé en 1982 par King et collaborateurs du Centre National de Défense Médicale de Taiwan, en se basant sur sa forte activité antileucémique. Comme d’autres flavaglines, le rocaglamide présente de puissantes activités insecticides, antifongiques, anti-inflammatoires, et surtout anticancéreuses.nflammatoires, et surtout anticancéreuses.
, Rocaglamide is a natural product which bel … Rocaglamide is a natural product which belongs to a class of molecules called flavaglines. This compound was isolated in 1982 by King, Ming-Lu (金明儒) and colleagues based on its antileukemic activity. The name of Rocaglamide is named from two parts: Roc- and aglamide. Roc- means Republic of China(中華民國), the place in which this product isolated; aglamide indicates this product is isolated from Large-leaved Aglaia (Latin: ). Like other flavaglines, rocaglamide displays potent insecticidal, antifungal, anti-inflammatory and anticancer activities. Rocaglamide A (RocA) inhibits eukaryotic translation initiation by binding to the translation initiation factor eIF4A and converting it into a translational repressor.verting it into a translational repressor.
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Rocaglamide
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