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Ribose-seq is a mapping technique used in … Ribose-seq is a mapping technique used in genetics research to determine the full profile of embedded ribonucleotides, specifically ribonucleoside monophosphates (rNMPs), in genomic DNA. Embedded ribonucleotides are thought to be the most common alteration to DNA in cells, and their presence in genomic DNA can affect genome stability. As recent studies have suggested that ribonucleotides in mouse DNA may affect disease pathology, ribonucleotide incorporation in genomic DNA has become an important target of medical genetics research. Ribose-seq allows scientists to determine the precise location and type of ribonucleotides that have been incorporated into eukaryotic or prokaryotic DNA. The technique exploits the presence of the extra hydroxyl groups (OH) found in the 2’ end of ribonucleotides, which can distort and destabilize DNA. The technique was developed through a collaboration with a group of researchers at the Georgia Institute of Technology including Francesca Storici and Kyung Duk Koh (now at the University of California San Francisco), and Jay Hesselberth at the University of Colorado Anschutz Medical School.rsity of Colorado Anschutz Medical School.
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Ribose-seq is a mapping technique used in … Ribose-seq is a mapping technique used in genetics research to determine the full profile of embedded ribonucleotides, specifically ribonucleoside monophosphates (rNMPs), in genomic DNA. Embedded ribonucleotides are thought to be the most common alteration to DNA in cells, and their presence in genomic DNA can affect genome stability. As recent studies have suggested that ribonucleotides in mouse DNA may affect disease pathology, ribonucleotide incorporation in genomic DNA has become an important target of medical genetics research. Ribose-seq allows scientists to determine the precise location and type of ribonucleotides that have been incorporated into eukaryotic or prokaryotic DNA.orated into eukaryotic or prokaryotic DNA.
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Ribose-seq
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