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Leishmaniose dérmica pós-kala-azar (PKDL) … Leishmaniose dérmica pós-kala-azar (PKDL) é uma sequela de Kala-azar que pode aparecer na pele dos indivíduos afetados até 20 anos após tratamento apropriado ou não. No Sudão, podem ser notados em até 60 por cento dos casos tratados. Eles se manifestar como pápulas, nódulos, ou eritema facial. Apesar de nenhum organismo causador de Kala-zar poder levar a PKLD, isto é comumente associado com L. donovani que dá diferentes padrões de doença na Índia e no Sudão. Na variante indiana, ocorrem nódulos que aumentam com o tempo e formam placas. Envolvimento de nervos periféricos pode ser comum em algumas regiões. Em um exame histológico, observam-se vários tipos de células inflamatórias crônicas; pode haver macrófagos ou . O diagnóstico envolve a demonstração do parasita por microscopia, cultura in vitro, inoculação, técnicas de diagnóstico imunológico e detecção de DNA no tecido. Novas ferramentas baseadas na PCR têm boa sensibilidade e especificidade. O surgimento de Leishmaniose dérmica pós-kala-azar em HIV positivos tem sido relatado. Estibogluconato de sódio (SSG) isoladamente ou em combinação com rifampicina é utilizado para o tratamento de PKLD a longo prazo (até quatro meses). de PKLD a longo prazo (até quatro meses).
, Post-kala-azar dermal leishmaniasis (PKDL) … Post-kala-azar dermal leishmaniasis (PKDL) is a complication of visceral leishmaniasis (VL); it is characterised by a macular, maculopapular, and nodular rash in a patient who has recovered from VL and who is otherwise well. The rash usually starts around the mouth from where it spreads to other parts of the body depending on severity. Post-kala-azar dermal leishmaniasis (also known as "Post-kala-azar dermatosis") found mainly on the face, arms, and upper part of the trunk. It occurs years (in the Indian variation) or a few months (in the African strain) after the successful treatment of visceral leishmaniasis. It is mainly seen in Sudan and India where it follows treated VL in 50% and 5-10% of cases, respectively. Thus, it is largely restricted to areas where Leishmania donovani is the causative parasite. The interval at which PKDL follows VL is 0–6 months in Sudan and 2–3 years in India. PKDL probably has an important role in interepidemic periods of VL, acting as a reservoir for parasites. PKDL was first identified by Sir Upendranath Brahmachari, who initially called it dermal leishmanoid. He published his observations in the Indian Medical Gazette in 1922.ons in the Indian Medical Gazette in 1922.
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Post-kala-azar dermal leishmaniasis (PKDL) … Post-kala-azar dermal leishmaniasis (PKDL) is a complication of visceral leishmaniasis (VL); it is characterised by a macular, maculopapular, and nodular rash in a patient who has recovered from VL and who is otherwise well. The rash usually starts around the mouth from where it spreads to other parts of the body depending on severity. PKDL was first identified by Sir Upendranath Brahmachari, who initially called it dermal leishmanoid. He published his observations in the Indian Medical Gazette in 1922.ons in the Indian Medical Gazette in 1922.
, Leishmaniose dérmica pós-kala-azar (PKDL) … Leishmaniose dérmica pós-kala-azar (PKDL) é uma sequela de Kala-azar que pode aparecer na pele dos indivíduos afetados até 20 anos após tratamento apropriado ou não. No Sudão, podem ser notados em até 60 por cento dos casos tratados. Eles se manifestar como pápulas, nódulos, ou eritema facial. Apesar de nenhum organismo causador de Kala-zar poder levar a PKLD, isto é comumente associado com L. donovani que dá diferentes padrões de doença na Índia e no Sudão. Na variante indiana, ocorrem nódulos que aumentam com o tempo e formam placas. Envolvimento de nervos periféricos pode ser comum em algumas regiões. Em um exame histológico, observam-se vários tipos de células inflamatórias crônicas; pode haver macrófagos ou .órias crônicas; pode haver macrófagos ou .
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Leishmaniose dérmica pós-calazar
, Post-kala-azar dermal leishmaniasis
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