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Piromelatine (Neu-P11) is a multimodal sle … Piromelatine (Neu-P11) is a multimodal sleep drug under development by . It is an agonist at melatonin MT1/MT2 and serotonin 5-HT1A/5-HT1D receptors. Neurim is conducting a phase II randomized, placebo controlled trial of cognitive and sleep effects in Alzheimer's disease. Results of a phase II trial on insomnia in 120 adults were announced in 2013, finding piromelatine 20/50 mg improved sleep over 4 weeks vs placebo. Phase 1A/1B studies in 2011, showed safe dose-dependent improvement in sleep. Pre-clinical studies showed antinociceptive antihypertensive and cognitive benefits in rat disease models of pain, hypertension, and Alzheimer's disease. Antidepressant and anti-anxiety effects were also demonstrated in animal models.s were also demonstrated in animal models.
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Piromelatine (Neu-P11) is a multimodal sle … Piromelatine (Neu-P11) is a multimodal sleep drug under development by . It is an agonist at melatonin MT1/MT2 and serotonin 5-HT1A/5-HT1D receptors. Neurim is conducting a phase II randomized, placebo controlled trial of cognitive and sleep effects in Alzheimer's disease. Antidepressant and anti-anxiety effects were also demonstrated in animal models.s were also demonstrated in animal models.
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Piromelatine
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