| http://dbpedia.org/ontology/abstract
|
The PilZ protein family is named after the … The PilZ protein family is named after the type IV pilus control protein first identified in Pseudomonas aeruginosa, expressed as part of the pil operon. It has a cytoplasmic location and is essential for type IV fimbrial, or pilus, biogenesis. PilZ is a c-di-GMP binding domain and PilZ domain-containing proteins represent the best studied class of c-di-GMP effectors. C-di-GMP, cyclic diguanosine monophosphate, the second messenger in cells, is widespread in and unique to the bacterial kingdom. Elevated intracellular levels of c-di-GMP generally cause bacteria to change from a motile single-cell state to a sessile, adhesive surface-attached multicellular state called biofilm. Proteins which contain PilZ are known to interact with the flagellar switch-complex proteins FliG and FliM and this is mediated via the c-di-GMP-PliZ complex. This interaction results in a reduction of torque-generation and induces counterclockwise motor bias that slows the motor and induces counterclockwise rotation, inhibiting chemotaxis. Binding and mutagenesis studies of several PilZ domain proteins have shown that c-di-GMP binding depends on residues in RxxxR and D/NxSxxG sequence-motifs. The crystal structure, at 1.7 A, of a PilZ domain::c-di-GMP complex from Vibrio cholerae shows c-di-GMP contacting seven of nine strongly conserved residues. Binding of c-di-GMP causes a conformational switch whereby the C- and N-terminal domains are brought into close opposition forming a new allosteric interaction surface that spans these domains and the c-di-GMP at their interface. The PilZ domain is also implicated in the bacterial pathogenicity of the Lyme disease spirochaete, Borrelia burgdorferi, through its binding partner c-di-GMP.eri, through its binding partner c-di-GMP.
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| http://dbpedia.org/ontology/symbol
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PilZ
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http://commons.wikimedia.org/wiki/Special:FilePath/PDB_1ywu_EBI.jpg?width=300 +
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31902906
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5492
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995942874
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http://dbpedia.org/resource/Chemotaxis +
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, http://dbpedia.org/resource/Effector_%28biology%29 +
, http://dbpedia.org/resource/Motile +
, http://dbpedia.org/resource/Carrier_protein +
, http://dbpedia.org/resource/Sessility_%28zoology%29 +
, http://dbpedia.org/resource/Pseudomonas_aeruginosa +
, http://dbpedia.org/resource/Flagellar_motor_switch +
, http://dbpedia.org/resource/Spirochaete +
, http://dbpedia.org/resource/Vibrio_cholerae +
, http://dbpedia.org/resource/Torque +
, http://dbpedia.org/resource/Biofilm +
, http://dbpedia.org/resource/Sequence_motif +
, http://dbpedia.org/resource/Mutagenesis%2C_site-directed +
, http://dbpedia.org/resource/Lyme_disease +
, http://dbpedia.org/resource/Protein%E2%80%93protein_interaction +
, http://dbpedia.org/resource/Type_IV_pilus +
, http://dbpedia.org/resource/Cell_%28biology%29 +
, http://dbpedia.org/resource/Allosteric_interaction +
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, http://dbpedia.org/resource/Fimbria_%28bacteriology%29 +
, http://dbpedia.org/resource/Protein +
, http://dbpedia.org/resource/Crystal_structure +
, http://dbpedia.org/resource/Biogenesis +
, http://dbpedia.org/resource/Cytoplasm +
, http://dbpedia.org/resource/Category:Protein_domains +
, http://dbpedia.org/resource/Adhesive_surface_forces +
, http://dbpedia.org/resource/Flagellar_motility +
, http://dbpedia.org/resource/Multicellular_organism +
, http://dbpedia.org/resource/Pathogenicity +
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| http://dbpedia.org/property/caption
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the solution NMR structure of the protein of unknown function vca0042 from vibrio cholerae o1
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| http://dbpedia.org/property/interpro
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IPR009875
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| http://dbpedia.org/property/name
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PilZ
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| http://dbpedia.org/property/pfam
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PF07238
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| http://dbpedia.org/property/symbol
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PilZ
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http://dbpedia.org/resource/Template:InterPro_content +
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http://dbpedia.org/resource/Category:Protein_domains +
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| rdfs:comment |
The PilZ protein family is named after the … The PilZ protein family is named after the type IV pilus control protein first identified in Pseudomonas aeruginosa, expressed as part of the pil operon. It has a cytoplasmic location and is essential for type IV fimbrial, or pilus, biogenesis. PilZ is a c-di-GMP binding domain and PilZ domain-containing proteins represent the best studied class of c-di-GMP effectors. C-di-GMP, cyclic diguanosine monophosphate, the second messenger in cells, is widespread in and unique to the bacterial kingdom. Elevated intracellular levels of c-di-GMP generally cause bacteria to change from a motile single-cell state to a sessile, adhesive surface-attached multicellular state called biofilm.tached multicellular state called biofilm.
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| rdfs:label |
PilZ domain
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