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Phenotypic response surfaces (PRS) is an a … Phenotypic response surfaces (PRS) is an artificial intelligence-guided personalized medicine platform that relies on combinatorial optimization principles to quantify drug interactions and efficacies to develop optimized combination therapies to treat a broad spectrum of illnesses. Phenotypic response surfaces fit a parabolic surface to a set of drug doses and biomarker values based on the understanding that the relationship between drugs, their interactions, and their effect on the measure biomarker can be modeled by quadric surface. The resulting surface allows for the omission of both in-vitro and in-silico screening of multi-drug combinations based on a patients unique phenotypic response. This provides a method to utilize small data sets to create time-critical personalized therapies that is independent of the disease or drug mechanism. The adaptable nature of the platform allows it to tackle a wide range of applications from isolating novel combination therapies to predicting daily drug regimen adjustments to support in-patient treatments.ustments to support in-patient treatments.
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| rdfs:comment |
Phenotypic response surfaces (PRS) is an a … Phenotypic response surfaces (PRS) is an artificial intelligence-guided personalized medicine platform that relies on combinatorial optimization principles to quantify drug interactions and efficacies to develop optimized combination therapies to treat a broad spectrum of illnesses.es to treat a broad spectrum of illnesses.
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Phenotypic response surfaces
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