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Periannan Senapathy is a molecular biologi … Periannan Senapathy is a molecular biologist, geneticist, author and entrepreneur. He is the founder, president and chief scientific officer at Genome International Corporation, a biotechnology, bioinformatics, and information technology firm based in Madison, Wisconsin, which develops computational genomics applications of next-generation DNA sequencing (NGS) and clinical decision support systems for analyzing patient genome data that aids in diagnosis and treatment of diseases. Dr. Senapathy is known for his contributions in genetics, genomics and clinical genomics, especially in the biology of RNA splicing and the split structure of eukaryotic genes. He developed the Shapiro & Senapathy algorithm (S&S) for predicting the splice sites, exons and genes of eukaryotes, which has become the primary methodology for discovering disease-causing mutations in splice junctions. The S&S has been implemented in many gene-finding and mutation detection tools that are used extensively in major clinical and research institutions around the world for uncovering mutations in thousands of patients with numerous diseases, including cancers and inherited disorders. It is increasingly used in the Next Generation Sequencing era, as it is widely realized that >50% of all diseases and adverse drug reactions in humans and other animals possibly occur within the splicing regions of genes. The S&S algorithm has been cited in ~4,000 publications on finding splicing mutations in thousands of cancer and inherited disorders. Dr. Senapathy offered a new hypothesis on the origin of introns, split genes and splice junctions in eukaryotic genes. As the split structure of genes is central to eukaryotic biology, their origin has been a major question in biology. Dr. Senapathy proposed the "split gene theory," which states that the split structure arose due to the origin of split genes from random DNA sequences, and provided tangible evidence from genome sequences of several organisms. He also showed that the splice junctions of eukaryotic genes could have originated from the stop codon ends of the Open Reading Frames (ORFs) in random DNA sequences based on analysis of eukaryotic genomic DNA sequences. Dr. Marshall Nirenberg, the Nobel Laureate who had deciphered codons, communicated the papers to the PNAS. Senapathy has published his other scientific findings in journals including Science, Nucleic Acids Research, PNAS, Journal of Biological Chemistry, and Journal of Molecular Biology, and is the author of several patents in the genomics field. of several patents in the genomics field.
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Periannan Senapathy is a molecular biologi … Periannan Senapathy is a molecular biologist, geneticist, author and entrepreneur. He is the founder, president and chief scientific officer at Genome International Corporation, a biotechnology, bioinformatics, and information technology firm based in Madison, Wisconsin, which develops computational genomics applications of next-generation DNA sequencing (NGS) and clinical decision support systems for analyzing patient genome data that aids in diagnosis and treatment of diseases.ds in diagnosis and treatment of diseases.
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