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Papillary carcinomas of the breast (PCB), … Papillary carcinomas of the breast (PCB), also termed malignant papillary carcinomas of the breast, are rare forms of the breast cancers. The World Health Organization (2019) classified papillary neoplasms (i.e. benign or cancerous tumors) of the breast into 5 types: intraductal papilloma, papillary ductal carcinoma in situ (PDCIS), encapsulated papillary carcinoma (EPC), solid-papillary carcinoma (SPC), and invasive papillary carcinoma (IPC). The latter four carcinomas are considered here; intraductal papilloma is a benign neoplasm considered in its Wikipedia page. The World Health Organization regarded solid papillary carcinoma as having two subtypes: in situ and invasive SPC. PCB develop from the epithelial cells that line the outer surfaces of ducts leading from exocrine glands or organs, blood vessels, or inner surfaces of the cavities in many internal organs. PCB are carcinomas derived from the epithelial cells of mammary gland ducts. They are a clinically, histologically, and biologically heterogeneous group of breast cancers that are often difficult to distinguish from each other as well as from other papillary breast lesions. The identification of PBS tumors may require the input of breast pathologists familiar with papillary lesions of the breast. The four types of PCB are defined and diagnosed in part by several of their microscopic features including: 1) the presence of tumor invasion into adjacent normal tissues; 2) the presence and location of myoepithelial cells, i.e. cells that normally rest on the basement membrane of mammary gland ducts and function to contract and thereby expel milk from mammary glands (these cells are identified by immunohistochemistry staining tumor tissue with, e.g. cytokeratin 5/6 antibodies that detect two markers of myoepithelial cells, cytokeratin 5 and keratin 6A); 3) the presence of a thick fibrous capsule enclosing the carcinoma; 4) the presence of areas of neuroendocrine differentiation, i.e. sites of accumulated neoplastic cells with features combining those of nerve and hormone-producing cells including in particular the presence of neurosecretory granules, i.e. cytoplasmic granules about 180 nanometers in diameter that are found in neurons and secretory cells; and 5) the presence of signet ring-shaped cells bearing mucin-containing granules.d cells bearing mucin-containing granules.
, Il carcinoma papillare in campo medico, è una forma di carcinoma che colpisce la mammella. Fra i tumori simili ricopre un 1-2% della casistica.
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Malignant papillary carcinomas of the breast
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Papillary carcinomas of the breast
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Primarily middle aged and older females and, uncommonly, males
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excellent
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Breast pathology, Medical oncology, Surgical oncology
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Malignant papillary carcinomas of the breast
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Papillary ductal carcinoma in situ; Encapsulated papillary carcinoma; Solid-papillary carcinoma; Invasive papillary carcinoma
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| rdfs:comment |
Il carcinoma papillare in campo medico, è una forma di carcinoma che colpisce la mammella. Fra i tumori simili ricopre un 1-2% della casistica.
, Papillary carcinomas of the breast (PCB), … Papillary carcinomas of the breast (PCB), also termed malignant papillary carcinomas of the breast, are rare forms of the breast cancers. The World Health Organization (2019) classified papillary neoplasms (i.e. benign or cancerous tumors) of the breast into 5 types: intraductal papilloma, papillary ductal carcinoma in situ (PDCIS), encapsulated papillary carcinoma (EPC), solid-papillary carcinoma (SPC), and invasive papillary carcinoma (IPC). The latter four carcinomas are considered here; intraductal papilloma is a benign neoplasm considered in its Wikipedia page. The World Health Organization regarded solid papillary carcinoma as having two subtypes: in situ and invasive SPC.ng two subtypes: in situ and invasive SPC.
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Papillary carcinomas of the breast
, Carcinoma papillare
|
