| http://dbpedia.org/ontology/abstract
|
Les PHLPP (de l'anglais : PH domain and Le … Les PHLPP (de l'anglais : PH domain and Leucine rich repeat Protein Phosphatase) sont une famille de protéines de type phosphatase, permettant l'inactivation des protéine Akt. Cette famille est composée de trois isoformes : PHLPP1α, PHLPP1β (issu du même gène PHLPP1 mais épissée différemment) et PHLPP2.LPP1 mais épissée différemment) et PHLPP2.
, The PHLPP isoforms (PH domain and Leucine … The PHLPP isoforms (PH domain and Leucine rich repeat Protein Phosphatases) are a pair of protein phosphatases, PHLPP1 and PHLPP2, that are important regulators of Akt serine-threonine kinases (Akt1, Akt2, Akt3) and conventional/novel protein kinase C (PKC) isoforms. PHLPP may act as a tumor suppressor in several types of cancer due to its ability to block growth factor-induced signaling in cancer cells. PHLPP dephosphorylates Ser-473 (the hydrophobic motif) in Akt, thus partially inactivating the kinase. In addition, PHLPP dephosphorylates conventional and novel members of the protein kinase C family at their hydrophobic motifs, corresponding to Ser-660 in PKCβII.otifs, corresponding to Ser-660 in PKCβII.
|
| http://dbpedia.org/ontology/arm
|
q
|
| http://dbpedia.org/ontology/band
|
21.32
, 22.2
|
| http://dbpedia.org/ontology/chromosome
|
16
, 18
|
| http://dbpedia.org/ontology/ecNumber
|
3.1.3.16
|
| http://dbpedia.org/ontology/entrezgene
|
23035
, 23239
|
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|
29149
, 20610
|
| http://dbpedia.org/ontology/omim
|
611066
, 609396
|
| http://dbpedia.org/ontology/refseq
|
XM_166290
, NM_015020
|
| http://dbpedia.org/ontology/symbol
|
PHLPP1, PLEKHE1
, PHLPPL
, PHLPP
, PHLPP2
|
| http://dbpedia.org/ontology/uniprot
|
Q6ZVD8
, O60346
|
| http://dbpedia.org/ontology/wikiPageID
|
10292285
|
| http://dbpedia.org/ontology/wikiPageLength
|
12054
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|
1118754945
|
| http://dbpedia.org/ontology/wikiPageWikiLink
|
http://dbpedia.org/resource/Magnesium +
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, http://dbpedia.org/resource/Protein_kinase_C +
, http://dbpedia.org/resource/N-terminus +
, http://dbpedia.org/resource/Oncogene +
, http://dbpedia.org/resource/PIP3 +
|
| http://dbpedia.org/property/altsymbols
|
PHLPP2
, PHLPP1, PLEKHE1
|
| http://dbpedia.org/property/arm
|
q
|
| http://dbpedia.org/property/band
|
21.32
, 22.2
|
| http://dbpedia.org/property/chromosome
|
16
, 18
|
| http://dbpedia.org/property/ecnumber
|
3.1
|
| http://dbpedia.org/property/entrezgene
|
23035
, 23239
|
| http://dbpedia.org/property/hgncid
|
20610
, 29149
|
| http://dbpedia.org/property/name
|
http://dbpedia.org/resource/PHLPPL +
, http://dbpedia.org/resource/PHLPP_%28gene%29 +
|
| http://dbpedia.org/property/omim
|
611066
, 609396
|
| http://dbpedia.org/property/refseq
|
XM_166290
, NM_015020
|
| http://dbpedia.org/property/symbol
|
http://dbpedia.org/resource/PHLPPL +
, http://dbpedia.org/resource/PHLPP_%28gene%29 +
|
| http://dbpedia.org/property/uniprot
|
O60346
, Q6ZVD8
|
| http://dbpedia.org/property/wikiPageUsesTemplate
|
http://dbpedia.org/resource/Template:Citation_needed +
, http://dbpedia.org/resource/Template:Esterases +
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|
| http://purl.org/dc/terms/subject
|
http://dbpedia.org/resource/Category:Signal_transduction +
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|
| http://purl.org/linguistics/gold/hypernym
|
http://dbpedia.org/resource/Pair +
|
| http://www.w3.org/ns/prov#wasDerivedFrom
|
http://en.wikipedia.org/wiki/PHLPP?oldid=1118754945&ns=0 +
|
| http://xmlns.com/foaf/0.1/isPrimaryTopicOf
|
http://en.wikipedia.org/wiki/PHLPP +
|
| http://xmlns.com/foaf/0.1/name
|
PH domain and leucine-rich repeat protein phosphatase
, PH domain and leucine rich repeat protein phosphatase-like
|
| owl:sameAs |
http://dbpedia.org/resource/PHLPP +
, http://www.wikidata.org/entity/Q7119246 +
, http://rdf.freebase.com/ns/m.02q7lz3 +
, https://global.dbpedia.org/id/4sZxF +
, http://fr.dbpedia.org/resource/PHLPP +
|
| rdf:type |
http://dbpedia.org/ontology/Place +
, http://dbpedia.org/ontology/Biomolecule +
, http://umbel.org/umbel/rc/ProteinMolecule +
, http://www.wikidata.org/entity/Q8054 +
, http://www.wikidata.org/entity/Q206229 +
, http://dbpedia.org/ontology/Protein +
|
| rdfs:comment |
Les PHLPP (de l'anglais : PH domain and Le … Les PHLPP (de l'anglais : PH domain and Leucine rich repeat Protein Phosphatase) sont une famille de protéines de type phosphatase, permettant l'inactivation des protéine Akt. Cette famille est composée de trois isoformes : PHLPP1α, PHLPP1β (issu du même gène PHLPP1 mais épissée différemment) et PHLPP2.LPP1 mais épissée différemment) et PHLPP2.
, The PHLPP isoforms (PH domain and Leucine … The PHLPP isoforms (PH domain and Leucine rich repeat Protein Phosphatases) are a pair of protein phosphatases, PHLPP1 and PHLPP2, that are important regulators of Akt serine-threonine kinases (Akt1, Akt2, Akt3) and conventional/novel protein kinase C (PKC) isoforms. PHLPP may act as a tumor suppressor in several types of cancer due to its ability to block growth factor-induced signaling in cancer cells. PHLPP dephosphorylates Ser-473 (the hydrophobic motif) in Akt, thus partially inactivating the kinase.t, thus partially inactivating the kinase.
|
| rdfs:label |
PHLPP
|
