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PDBsum is a database that provides an over … PDBsum is a database that provides an overview of the contents of each 3D macromolecular structure deposited in the Protein Data Bank. The original version of the database was developed around 1995 by Roman Laskowski and collaborators at University College London. As of 2014, PDBsum is maintained by Laskowski and collaborators in the laboratory of Janet Thornton at the European Bioinformatics Institute (EBI). Each structure in the PDBsum database includes an image of structure (main view, Bottom view and right view), molecular components contained in the complex(structure), enzyme reaction diagram if appropriate, Gene ontology functional assignments, a 1D sequence annotated by Pfam and InterPro domain assignments, description of bound molecules and graphic showing interactions between protein and secondary structure, schematic diagrams of protein–protein interactions, analysis of clefts contained within the structure and links to external databases. The RasMol and Jmol molecular graphics software are used to provide a 3D view of molecules and their interactions within PDBsum. Since the release of the 1000 Genomes Project in October 2012, all single amino acid variants identified by the project have been mapped to the corresponding protein sequences in the Protein Data Bank. These variants are also displayed within PDBsum, cross-referenced to the relevant UniProt identifier. PDBsum contains a number of protein structures that may be of interest in structure-based drug design. One branch of PDBsum, known as DrugPort, focuses on these models and is linked with the DrugBank drug target database.ed with the DrugBank drug target database.
, PDBSum és una base de dades que proporcion … PDBSum és una base de dades que proporciona una visió general en tres dimensions del contingut de cada estructura macromolecular dipositada a la Protein Data Bank. La versió original de la base de dades va ser desenvolupada al 1995 per i col·laboradors a la University College de Londres. Posteriorment l'han anat actualitzant i mantenint de forma col·laborativa amb Janet Thornton a l'European Bioinformatics Institute (EBI). Cada estructura macromolecular a la base de dades de PDBsum inclou una imatge de la seva estructura (vista principal, vista inferior i vista dreta), els components moleculars que conté el complex, un diagrama de la reacció enzimàtica si escau, ontologia genètica i assignacions funcionals de la proteïna, una seqüència unidireccional marcada per assignacions de dominis Pfam i InterPro, una descripció dels enllaços moleculars amb un gràfic que mostra les interaccions entre proteïna i estructura secundària, diagrames esquemàtics d'interaccions proteïna-proteïna, una anàlisi de clivelles contingudes a l'estructura, i enllaços a bases de dades externes. S'utilitzen els software de gràfics moleculars de RasMol i Jmol per la visualització en 3D de les molècules i les seves interaccions. Des del llançament del l'octubre de 2012, tots els totes les variants d'aminoàcids individuals identificades pel projecte s'han inclòs a les seqüències de proteïnes corresponents al Protein Data Bank. Aquestes variants també es mostren dins de PDBsum, amb referències creuades a l'identificador UniProt corresponent. PDBsum també conté una gran quantitat d'estructures proteiques que poden ser d'interès en el disseny de nous fàrmacs, i té una branca a part coneguda com a DrugPort que se centra en aquests models i està connectada amb la base de dades de DrugBank.nnectada amb la base de dades de DrugBank.
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PDBsum is a database that provides an over … PDBsum is a database that provides an overview of the contents of each 3D macromolecular structure deposited in the Protein Data Bank. The original version of the database was developed around 1995 by Roman Laskowski and collaborators at University College London. As of 2014, PDBsum is maintained by Laskowski and collaborators in the laboratory of Janet Thornton at the European Bioinformatics Institute (EBI).e European Bioinformatics Institute (EBI).
, PDBSum és una base de dades que proporcion … PDBSum és una base de dades que proporciona una visió general en tres dimensions del contingut de cada estructura macromolecular dipositada a la Protein Data Bank. La versió original de la base de dades va ser desenvolupada al 1995 per i col·laboradors a la University College de Londres. Posteriorment l'han anat actualitzant i mantenint de forma col·laborativa amb Janet Thornton a l'European Bioinformatics Institute (EBI).l'European Bioinformatics Institute (EBI).
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