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TNFSF4, или OX40L (от англ. Tumor necrosis factor ligand superfamily member 4; OX40 ligand) — цитокин семейства факторов некроза опухоли, лиганд рецептора CD134 (OX40). Продукт гена человека TNFSF4.
, OX40L je ligandem molekuly (známé také pod … OX40L je ligandem molekuly (známé také pod názvy CD134 nebo TNFRSF4) a je stabilně exprimován na mnoha antigen prezentujících buňkách, například dendritických buňkách (typu DC2), makrofázích a aktivovaných B lymfocytech. Molekula OX40 se nachází především na povrchu aktivovaných T lymfocytů (především CD4+), ale také NK buněk, NKT buněk a neutrofilů. OX40-OX40L vede k produkci signálu přežití T buněk (survival signálu) a napomáhá vývoji paměťových T lymfocytů. Tato interakce též indukuje polarizaci směrem k Th2 imunitní odpovědi, a to i v prostředí s nízkou hladinou IL-4 cytokinu (Th2 polarizace nezávislá na IL-4). OX40L je rovněž přítomen na povrchu mnoha neimunitních buněk, například buněk endotelu a buněk hladké svaloviny. Povrchová exprese molekuly OX40L je indukována mnoha prozánětlivými mediátory, například TNF-α, produkovaným žírnými buňkami, IFN-γ a PGE2 (prostaglandinem E2). OX40L je označován též jako CD252 (diferenciační skupina 252). Bylo identifikováno mnoho jednonukleotidových polymorfismů (SNPs) v genu pro OX40L. Pro některé z nich byla zjištěna asociace se systémovým lupem. Dosud nebyla zjištěna korelace polymorfismů v OX40L s výskytem aterosklerózy.morfismů v OX40L s výskytem aterosklerózy.
, La superfamiglia dei ligando del tumor nec … La superfamiglia dei ligando del tumor necrosis factor 4, anche nota come TNFSF4, comprende le varie isoforme del ligando del TNF. È espresso in un sottotipo di cellula dendritica (DC2s) e attiva l'amplificazione della differenziazione cellulare dei linfociti Th2.ferenziazione cellulare dei linfociti Th2.
, OX40L is the ligand for OX40 (also known a … OX40L is the ligand for OX40 (also known as CD134 or TNFRSF4) and is stably expressed on many antigen-presenting cells such as DC2s (a subtype of dendritic cells), macrophages, and activated B lymphocytes. The OX40 molecule, conversely, is present on the surface of activated T lymphocytes (mainly CD4+ T cells), but also on NK cells, NKT cells, and neutrophils. The ligation of OX40-OX40L is a source of survival signal for T cells and enables the development of memory T cells. Signaling through these two molecules also leads to polarization towards Th2 immune response even in an environment with low levels of IL-4 cytokine. OX40L is also present on the surface of many non-immune cells, for example, endothelial cells and smooth muscle cells. The surface expression of OX40L is induced by many pro-inflammatory mediators, such as TNF-α, e.g. produced by mast cells, IFN-γ and PGE2 (prostaglandin E2). OX40L has also been designated CD252 (cluster of differentiation 252). Various single-nucleotide polymorphisms (SNPs) of the OX40L gene have been identified. For some of them association with systemic lupus erythematosus has been reported. No association with occurrence of atherosclerosis has been found.urrence of atherosclerosis has been found.
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| rdfs:comment |
TNFSF4, или OX40L (от англ. Tumor necrosis factor ligand superfamily member 4; OX40 ligand) — цитокин семейства факторов некроза опухоли, лиганд рецептора CD134 (OX40). Продукт гена человека TNFSF4.
, OX40L je ligandem molekuly (známé také pod … OX40L je ligandem molekuly (známé také pod názvy CD134 nebo TNFRSF4) a je stabilně exprimován na mnoha antigen prezentujících buňkách, například dendritických buňkách (typu DC2), makrofázích a aktivovaných B lymfocytech. OX40L je rovněž přítomen na povrchu mnoha neimunitních buněk, například buněk endotelu a buněk hladké svaloviny. Povrchová exprese molekuly OX40L je indukována mnoha prozánětlivými mediátory, například TNF-α, produkovaným žírnými buňkami, IFN-γ a PGE2 (prostaglandinem E2). OX40L je označován též jako CD252 (diferenciační skupina 252).éž jako CD252 (diferenciační skupina 252).
, OX40L is the ligand for OX40 (also known a … OX40L is the ligand for OX40 (also known as CD134 or TNFRSF4) and is stably expressed on many antigen-presenting cells such as DC2s (a subtype of dendritic cells), macrophages, and activated B lymphocytes. OX40L is also present on the surface of many non-immune cells, for example, endothelial cells and smooth muscle cells. The surface expression of OX40L is induced by many pro-inflammatory mediators, such as TNF-α, e.g. produced by mast cells, IFN-γ and PGE2 (prostaglandin E2). OX40L has also been designated CD252 (cluster of differentiation 252).ed CD252 (cluster of differentiation 252).
, La superfamiglia dei ligando del tumor nec … La superfamiglia dei ligando del tumor necrosis factor 4, anche nota come TNFSF4, comprende le varie isoforme del ligando del TNF. È espresso in un sottotipo di cellula dendritica (DC2s) e attiva l'amplificazione della differenziazione cellulare dei linfociti Th2.ferenziazione cellulare dei linfociti Th2.
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| rdfs:label |
OX40 ligand
, OX40L
, TNFSF4
|
