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Notch — семейство трансмембранных белков, … Notch — семейство трансмембранных белков, содержащие повторяющиеся внеклеточные последовательности — домены EGF и DSL. Эти белки принимают участие в латеральном ингибировании и эмбриогенезе. является эволюционно консервативным внутриклеточным путём передачи сигнала и регулирует взаимодействия между соседними клетками. У дрозофилы взаимодействия Notch с лигандами включает внутриклеточный путь передачи сигнала, который играет ключевую роль в развитии. Представители этого семейства имеют характеристики, сходные с внеклеточным доменом фактора роста эпидермиса (EGF).ым доменом фактора роста эпидермиса (EGF).
, Notch proteins are a family of type-1 tran … Notch proteins are a family of type-1 transmembrane proteins that form a core component of the Notch signaling pathway, which is highly conserved in metazoans. The Notch extracellular domain mediates interactions with DSL family ligands, allowing it to participate in juxtacrine signaling. The Notch intracellular domain acts as a transcriptional activator when in complex with CSL family transcription factors. Members of this Type 1 transmembrane protein family share several core structures, including an extracellular domain consisting of multiple epidermal growth factor (EGF)-like repeats and an intracellular domain transcriptional activation domain (TAD). Notch family members operate in a variety of different tissues and play a role in a variety of developmental processes by controlling cell fate decisions. Much of what is known about Notch function comes from studies done in Caenorhabditis elegans (C.elegans) and Drosophila melanogaster. Human homologs have also been identified, but details of Notch function and interactions with its ligands are not well known in this context.igands are not well known in this context.
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Notch
, DSL
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Structure of a prototype LNR module from human Notch 1
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IPR026219
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Notch domain
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SM00004
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DSL
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| rdfs:comment |
Notch — семейство трансмембранных белков, … Notch — семейство трансмембранных белков, содержащие повторяющиеся внеклеточные последовательности — домены EGF и DSL. Эти белки принимают участие в латеральном ингибировании и эмбриогенезе. является эволюционно консервативным внутриклеточным путём передачи сигнала и регулирует взаимодействия между соседними клетками. У дрозофилы взаимодействия Notch с лигандами включает внутриклеточный путь передачи сигнала, который играет ключевую роль в развитии. Представители этого семейства имеют характеристики, сходные с внеклеточным доменом фактора роста эпидермиса (EGF).ым доменом фактора роста эпидермиса (EGF).
, Notch proteins are a family of type-1 tran … Notch proteins are a family of type-1 transmembrane proteins that form a core component of the Notch signaling pathway, which is highly conserved in metazoans. The Notch extracellular domain mediates interactions with DSL family ligands, allowing it to participate in juxtacrine signaling. The Notch intracellular domain acts as a transcriptional activator when in complex with CSL family transcription factors. Members of this Type 1 transmembrane protein family share several core structures, including an extracellular domain consisting of multiple epidermal growth factor (EGF)-like repeats and an intracellular domain transcriptional activation domain (TAD). Notch family members operate in a variety of different tissues and play a role in a variety of developmental processes by controlling ce developmental processes by controlling ce
|
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Notch proteins
, Notch
|
