http://dbpedia.org/ontology/abstract
|
Nortilidin ist ein pharmakologisch aktives … Nortilidin ist ein pharmakologisch aktives Stoffwechselprodukt (Metabolit) des Arzneistoffs Tilidin. Die Substanz aus der Gruppe der Opioide entsteht in der Leber durch Demethylierung aus Tilidin. Nortilidin übt die hauptsächliche Wirkung des verabreichten Tilidins aus, da dieses als Prodrug kaum Wirkung zeigt. Nortilidin wird weiterhin in der Leber nach und nach zum analgetisch inaktiven Bisnortilidin metabolisiert.sch inaktiven Bisnortilidin metabolisiert.
, Nortilidine is the major active metabolite … Nortilidine is the major active metabolite of tilidine. It is formed from tilidine by demethylation in the liver. The racemate has opioid analgesic effects roughly equivalent in potency to that of morphine. The (1R,2S) isomer has NMDA antagonist activity. The drug also acts as a dopamine reuptake inhibitor. The reversed-ester of nortilidine is also known, as is the corresponding analogue with the cyclohexene ring replaced by cyclopentane, which have almost identical properties to nortilidine.lmost identical properties to nortilidine.
|
http://dbpedia.org/ontology/casNumber
|
38677-94-0
|
http://dbpedia.org/ontology/chEBI
|
77839
|
http://dbpedia.org/ontology/chEMBL
|
1614654
|
http://dbpedia.org/ontology/fdaUniiCode
|
7145G6817J
|
http://dbpedia.org/ontology/pubchem
|
162321
|
http://dbpedia.org/ontology/thumbnail
|
http://commons.wikimedia.org/wiki/Special:FilePath/Nortilidine.svg?width=300 +
|
http://dbpedia.org/ontology/wikiPageID
|
31734951
|
http://dbpedia.org/ontology/wikiPageLength
|
4753
|
http://dbpedia.org/ontology/wikiPageRevisionID
|
1082987664
|
http://dbpedia.org/ontology/wikiPageWikiLink
|
http://dbpedia.org/resource/Active_metabolite +
, http://dbpedia.org/resource/Demethylation +
, http://dbpedia.org/resource/Designer_drug +
, http://dbpedia.org/resource/Desmetramadol +
, http://dbpedia.org/resource/Category:Cyclohexenes +
, http://dbpedia.org/resource/Dopamine_reuptake_inhibitor +
, http://dbpedia.org/resource/Category:Dopamine_reuptake_inhibitors +
, http://dbpedia.org/resource/Category:NMDA_receptor_antagonists +
, http://dbpedia.org/resource/Tilidine +
, http://dbpedia.org/resource/Tapentadol +
, http://dbpedia.org/resource/Liver +
, http://dbpedia.org/resource/NMDA_antagonist +
, http://dbpedia.org/resource/Category:Opioids +
|
http://dbpedia.org/property/c
|
16
|
http://dbpedia.org/property/casNumber
|
38677
|
http://dbpedia.org/property/chebi
|
77839
|
http://dbpedia.org/property/chembl
|
1614654
|
http://dbpedia.org/property/chemspiderid
|
142535
|
http://dbpedia.org/property/h
|
21
|
http://dbpedia.org/property/iupacName
|
ethyl -2--1-phenylcyclohex-3-ene-1-carboxylate
|
http://dbpedia.org/property/n
|
1
|
http://dbpedia.org/property/o
|
2
|
http://dbpedia.org/property/pubchem
|
162321
|
http://dbpedia.org/property/smiles
|
CCOC[C@]1C2=CC=CC=C2
|
http://dbpedia.org/property/stdinchi
|
1
|
http://dbpedia.org/property/stdinchikey
|
PDJZPNKVLDWEKI-GOEBONIOSA-N
|
http://dbpedia.org/property/unii
|
7145
|
http://dbpedia.org/property/wikiPageUsesTemplate
|
http://dbpedia.org/resource/Template:Ebicite +
, http://dbpedia.org/resource/Template:Opioidergics +
, http://dbpedia.org/resource/Template:Drugbox +
, http://dbpedia.org/resource/Template:Commons_category-inline +
, http://dbpedia.org/resource/Template:Short_description +
, http://dbpedia.org/resource/Template:Glutamatergics +
, http://dbpedia.org/resource/Template:Analgesic-stub +
, http://dbpedia.org/resource/Template:Reflist +
, http://dbpedia.org/resource/Template:Dopaminergics +
|
http://purl.org/dc/terms/subject
|
http://dbpedia.org/resource/Category:NMDA_receptor_antagonists +
, http://dbpedia.org/resource/Category:Cyclohexenes +
, http://dbpedia.org/resource/Category:Opioids +
, http://dbpedia.org/resource/Category:Dopamine_reuptake_inhibitors +
|
http://purl.org/linguistics/gold/hypernym
|
http://dbpedia.org/resource/Metabolite +
|
http://www.w3.org/ns/prov#wasDerivedFrom
|
http://en.wikipedia.org/wiki/Nortilidine?oldid=1082987664&ns=0 +
|
http://xmlns.com/foaf/0.1/depiction
|
http://commons.wikimedia.org/wiki/Special:FilePath/Nortilidine.svg +
|
http://xmlns.com/foaf/0.1/isPrimaryTopicOf
|
http://en.wikipedia.org/wiki/Nortilidine +
|
owl:sameAs |
http://www.wikidata.org/entity/Q12746349 +
, http://yago-knowledge.org/resource/Nortilidine +
, http://rdf.freebase.com/ns/m.0gtw4rz +
, http://dbpedia.org/resource/Nortilidine +
, http://de.dbpedia.org/resource/Nortilidin +
, http://sr.dbpedia.org/resource/Nortilidin +
, http://sh.dbpedia.org/resource/Nortilidin +
, https://global.dbpedia.org/id/JNmB +
|
rdf:type |
http://dbpedia.org/class/yago/Message106598915 +
, http://dbpedia.org/class/yago/Statement106722453 +
, http://dbpedia.org/ontology/Drug +
, http://dbpedia.org/class/yago/Communication100033020 +
, http://www.ontologydesignpatterns.org/ont/dul/DUL.owl#ChemicalObject +
, http://dbpedia.org/ontology/ChemicalSubstance +
, http://dbpedia.org/class/yago/MolecularFormula106817173 +
, http://dbpedia.org/class/yago/Formula106816935 +
, http://dbpedia.org/class/yago/WikicatMolecularFormulas +
, http://www.wikidata.org/entity/Q8386 +
, http://dbpedia.org/class/yago/Abstraction100002137 +
, http://dbpedia.org/ontology/ChemicalCompound +
|
rdfs:comment |
Nortilidine is the major active metabolite … Nortilidine is the major active metabolite of tilidine. It is formed from tilidine by demethylation in the liver. The racemate has opioid analgesic effects roughly equivalent in potency to that of morphine. The (1R,2S) isomer has NMDA antagonist activity. The drug also acts as a dopamine reuptake inhibitor. The reversed-ester of nortilidine is also known, as is the corresponding analogue with the cyclohexene ring replaced by cyclopentane, which have almost identical properties to nortilidine.lmost identical properties to nortilidine.
, Nortilidin ist ein pharmakologisch aktives … Nortilidin ist ein pharmakologisch aktives Stoffwechselprodukt (Metabolit) des Arzneistoffs Tilidin. Die Substanz aus der Gruppe der Opioide entsteht in der Leber durch Demethylierung aus Tilidin. Nortilidin übt die hauptsächliche Wirkung des verabreichten Tilidins aus, da dieses als Prodrug kaum Wirkung zeigt. Nortilidin wird weiterhin in der Leber nach und nach zum analgetisch inaktiven Bisnortilidin metabolisiert.sch inaktiven Bisnortilidin metabolisiert.
|
rdfs:label |
Nortilidine
, Nortilidin
|