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Никотинамидмономнуклеотид-аденилилтрансфер … Никотинамидмономнуклеотид-аденилилтрансфераза (англ. Nicotinamide mononucleotide adenylyltransferase; КФ 2.7.7.1) — фермент, катализирующий образование НАД+ из никотинамидмононуклеотида и АТФ. Реакция выглядит следующим образом: АТФ + никотинамидрибонуклеотид дифосфат + НАД++ никотинамидрибонуклеотид дифосфат + НАД+
, Nicotinamidmononukleotid-Adenylyltransfera … Nicotinamidmononukleotid-Adenylyltransferase (NMNAT) ist das Enzym, das die Übertragung eines Moleküls Adenosinmonophosphat (AMP) auf Nicotinamidmononukleotid (NMN) katalysiert. Dies ist der letzte Schritt bei der Biosynthese von NAD. NMNAT kommt in Tieren, Bakterien und manchen Pilzen vor. Die meisten Tiere haben zwei paraloge Gene für dieses Enzym, bei Menschen und Mäusen sind drei bekannt, deren Translationsprodukte in jeweils verschiedenen Gewebetypen und Zellkompartimenten lokalisiert sind.n und Zellkompartimenten lokalisiert sind.
, In enzymology, nicotinamide-nucleotide ade … In enzymology, nicotinamide-nucleotide adenylyltransferase (NMNAT) (EC 2.7.7.1) are enzymes that catalyzes the chemical reaction ATP + nicotinamide mononucleotide diphosphate + NAD+ Thus, the two substrates of this enzyme are ATP and nicotinamide mononucleotide (NMN), whereas its two products are diphosphate and NAD+. This enzyme participates in nicotinate and nicotinamide metabolism. Humans have three protein isoforms: NMNAT1 (widespread), NMNAT2 (predominantly in brain), and NMNAT3 (highest in liver, heart, skeletal muscle, and erythrocytes). Mutations in the NMNAT1 gene lead to the LCA9 form of Leber congenital amaurosis. Mutations in NMNAT2 or NMNAT3 genes are not known to cause any human disease. NMNAT2 is critical for neurons: loss of NMNAT2 is associated with neurodegeneration. All NMNAT isoforms reportedly decline with age.MNAT isoforms reportedly decline with age.
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| rdfs:comment |
In enzymology, nicotinamide-nucleotide ade … In enzymology, nicotinamide-nucleotide adenylyltransferase (NMNAT) (EC 2.7.7.1) are enzymes that catalyzes the chemical reaction ATP + nicotinamide mononucleotide diphosphate + NAD+ Thus, the two substrates of this enzyme are ATP and nicotinamide mononucleotide (NMN), whereas its two products are diphosphate and NAD+. This enzyme participates in nicotinate and nicotinamide metabolism.in nicotinate and nicotinamide metabolism.
, Никотинамидмономнуклеотид-аденилилтрансфер … Никотинамидмономнуклеотид-аденилилтрансфераза (англ. Nicotinamide mononucleotide adenylyltransferase; КФ 2.7.7.1) — фермент, катализирующий образование НАД+ из никотинамидмононуклеотида и АТФ. Реакция выглядит следующим образом: АТФ + никотинамидрибонуклеотид дифосфат + НАД++ никотинамидрибонуклеотид дифосфат + НАД+
, Nicotinamidmononukleotid-Adenylyltransfera … Nicotinamidmononukleotid-Adenylyltransferase (NMNAT) ist das Enzym, das die Übertragung eines Moleküls Adenosinmonophosphat (AMP) auf Nicotinamidmononukleotid (NMN) katalysiert. Dies ist der letzte Schritt bei der Biosynthese von NAD. NMNAT kommt in Tieren, Bakterien und manchen Pilzen vor. Die meisten Tiere haben zwei paraloge Gene für dieses Enzym, bei Menschen und Mäusen sind drei bekannt, deren Translationsprodukte in jeweils verschiedenen Gewebetypen und Zellkompartimenten lokalisiert sind.n und Zellkompartimenten lokalisiert sind.
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Nicotinamidnukleotid-Adenylyltransferase
, Никотинамидмономнуклеотид-аденилилтрансфераза
, Nicotinamide-nucleotide adenylyltransferase
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