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The NhaD family (TC# 2.A.62) belongs to th … The NhaD family (TC# 2.A.62) belongs to the Ion Transporter (IT) Superfamily. A representative list of proteins belonging to the NhaD family can be found in the Transporter Classification Database. The NhaD Na+/H+ antiporter has been characterized from two Vibrio species: V. parahaemolyticus and V. cholerae and in the haloalkaliphile, . These proteins and their homologues are 400-500 aas long and exhibit 10-13 TMSs. They catalyze Na+/H+ and Li+/H+ antiport. They exhibit activity at basic pH (8-10) with no activity at pH 7.5. The Amylolytica antiporter has low Na+ affinity and has optimal activity at 600 mM Na+. Homologues are found in Pseudomonadota of all groups, Flavobacteriia, and Chlamydia. Distant homologues of the IT superfamily are ubiquitous. The generalized reaction catalyzed by NhaD is: nH+ (in) + mNa+ (out) ⇌ nH+ (out) + mNa+ (in).(in) + mNa+ (out) ⇌ nH+ (out) + mNa+ (in).
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http://www.tcdb.org/search/result.php?tc=2.A.62|sourcearticle=2.A.62 The NhaD Na+:H+ Antiporter Family
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| rdfs:comment |
The NhaD family (TC# 2.A.62) belongs to th … The NhaD family (TC# 2.A.62) belongs to the Ion Transporter (IT) Superfamily. A representative list of proteins belonging to the NhaD family can be found in the Transporter Classification Database. The NhaD Na+/H+ antiporter has been characterized from two Vibrio species: V. parahaemolyticus and V. cholerae and in the haloalkaliphile, . These proteins and their homologues are 400-500 aas long and exhibit 10-13 TMSs. They catalyze Na+/H+ and Li+/H+ antiport. They exhibit activity at basic pH (8-10) with no activity at pH 7.5. The Amylolytica antiporter has low Na+ affinity and has optimal activity at 600 mM Na+. Homologues are found in Pseudomonadota of all groups, Flavobacteriia, and Chlamydia. Distant homologues of the IT superfamily are ubiquitous.gues of the IT superfamily are ubiquitous.
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| rdfs:label |
NhaD family
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