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http://dbpedia.org/ontology/abstract Multi-wavelength anomalous diffraction (soMulti-wavelength anomalous diffraction (sometimes Multi-wavelength anomalous dispersion; abbreviated MAD) is a technique used in X-ray crystallography that facilitates the determination of the three-dimensional structure of biological macromolecules (e.g. DNA, drug receptors) via solution of the phase problem. MAD was developed by Wayne Hendrickson while working as a postdoctoral researcher under Jerome Karle at the United States Naval Research Laboratory. The mathematics upon which MAD (and progenitor Single wavelength anomalous dispersion) were based were developed by Jerome Karle, work for which he was awarded the 1985 Nobel Prize in Chemistry (along with Herbert Hauptman).n Chemistry (along with Herbert Hauptman). , Se conoce como MAD (Multiwavelength AnomalSe conoce como MAD (Multiwavelength Anomalous Dispersion/Diffraction o Dispersión/Difracción Anómala Múltiple) a una técnica cristalográfica empleada para determinar la estructura de moléculas. Se basa en las pequeñas diferencias en la intensidad de la difracción causadas por el fenómeno de la dispersión anómala o absorción de los rayos X por ciertos átomos presentes en la molécula. Se utiliza principalmente para determinar la estructura de macromoléculas, como las proteínas. El uso de sincrotrones como fuentes de rayos X y el desarrollo teórico y experimental, llevado a cabo por Jerome Karle y entre otros, resultaron en una notable expansión del método a finales del siglo XX.​​nsión del método a finales del siglo XX.​​
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rdfs:comment Multi-wavelength anomalous diffraction (soMulti-wavelength anomalous diffraction (sometimes Multi-wavelength anomalous dispersion; abbreviated MAD) is a technique used in X-ray crystallography that facilitates the determination of the three-dimensional structure of biological macromolecules (e.g. DNA, drug receptors) via solution of the phase problem.eptors) via solution of the phase problem. , Se conoce como MAD (Multiwavelength AnomalSe conoce como MAD (Multiwavelength Anomalous Dispersion/Diffraction o Dispersión/Difracción Anómala Múltiple) a una técnica cristalográfica empleada para determinar la estructura de moléculas. Se basa en las pequeñas diferencias en la intensidad de la difracción causadas por el fenómeno de la dispersión anómala o absorción de los rayos X por ciertos átomos presentes en la molécula. Se utiliza principalmente para determinar la estructura de macromoléculas, como las proteínas. El uso de sincrotrones como fuentes de rayos X y el desarrollo teórico y experimental, llevado a cabo por Jerome Karle y entre otros, resultaron en una notable expansión del método a finales del siglo XX.​​nsión del método a finales del siglo XX.​​
rdfs:label Multi-wavelength anomalous dispersion , Difracción Anómala Múltiple
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