| http://dbpedia.org/ontology/abstract
|
Die Monoklonale Gammopathie renaler Signif … Die Monoklonale Gammopathie renaler Signifikanz (MGRS) stellt eine symptomatische Monoklonale Gammopathie mit einer Nierenerkrankung dar, bei der die Kriterien für eine (per Definition) maligne Erkrankung wie dem Multiplen Myelom nicht erfüllt sind. Somit ist die MGRS eine Krankheits-Vorstufe, bei der in bestimmten Fällen auch eine hämatologisch-onkologische Therapie notwendig sein kann. Im weiteren Sinne können auch maligne Erkrankungen wie die AL-Amyloidose als MGRS kategorisiert werden.-Amyloidose als MGRS kategorisiert werden.
, Monoclonal gammopathy of renal significanc … Monoclonal gammopathy of renal significance (MGRS) are a group of kidney disorders that present with kidney damage due to nephrotoxic monoclonal immunoglobulins (M proteins) secreted by clonal plasma cells or B cells. By definition, people with MGRS do not meet criteria for multiple myeloma or other hematologic malignancies. The term MGRS was introduced in 2012 by the International Kidney and Monoclonal Gammopathy Research Group (IKMG). MGRS is associated with monoclonal gammopathy of undetermined significance (MGUS). People with MGUS have a monoclonal gammopathy (presence of monoclonal immunoglobulins) but does not meet the criteria for the clonal burden nor the presence of end organ damage seen in hematologic malignancies. In a population based study based on the NHANES III health survey; 6% of patients with MGUS were subsequently classified as having MGRS. The prevalence and incidence of MGRS in the general population or in specific populations is not known but it is more prevalent in those over the age of 50 as there is a monoclonal protein (M-protein) present in 3% of those 50 and years older and 5% of those 70 years and older (the presence of MGUS), placing those 50 and older at increased risk of MGRS. MGRS disorders generally do not respond well to immunosuppressive treatment. MGRS disorders also have a greater than 90% rate of recurrence if the monoclonal gammopathy is not eliminated either before or immediately after a renal transplant. People with MGRS are at risk of progression to the corresponding hematologic malignancy. the corresponding hematologic malignancy.
|
| http://dbpedia.org/ontology/wikiPageID
|
68680620
|
| http://dbpedia.org/ontology/wikiPageLength
|
14575
|
| http://dbpedia.org/ontology/wikiPageRevisionID
|
1048560084
|
| http://dbpedia.org/ontology/wikiPageWikiLink
|
http://dbpedia.org/resource/Cyclophosphamide +
, http://dbpedia.org/resource/Plasma_cells +
, http://dbpedia.org/resource/Proteinuria +
, http://dbpedia.org/resource/Fanconi_Syndrome +
, http://dbpedia.org/resource/Serum_protein_electrophoresis +
, http://dbpedia.org/resource/Monoclonal_gammopathy_of_undetermined_significance +
, http://dbpedia.org/resource/Daratumumab +
, http://dbpedia.org/resource/Hematuria +
, http://dbpedia.org/resource/Complement_component_3 +
, http://dbpedia.org/resource/Monoclonal_antibody +
, http://dbpedia.org/resource/Bortezomib +
, http://dbpedia.org/resource/Monocytes +
, http://dbpedia.org/resource/CD20 +
, http://dbpedia.org/resource/Rituximab +
, http://dbpedia.org/resource/AL_amyloidosis +
, http://dbpedia.org/resource/B_cells +
, http://dbpedia.org/resource/CD38 +
, http://dbpedia.org/resource/Dexamethasone +
, http://dbpedia.org/resource/NHANES +
, http://dbpedia.org/resource/Category:Kidney_diseases +
, http://dbpedia.org/resource/Factor_H +
, http://dbpedia.org/resource/Alternative_complement_pathway +
, http://dbpedia.org/resource/Glomeruli +
, http://dbpedia.org/resource/Chronic_lymphocytic_leukemia +
, http://dbpedia.org/resource/UPEP +
, http://dbpedia.org/resource/Thalidomide +
, http://dbpedia.org/resource/Waldenstrom%27s_macroglobulinemia +
, http://dbpedia.org/resource/Nephron +
, http://dbpedia.org/resource/Transforming_growth_factor_beta +
, http://dbpedia.org/resource/Nephrotic_syndrome +
, http://dbpedia.org/resource/Multiple_myeloma +
, http://dbpedia.org/resource/Cryoglobulinemia +
, http://dbpedia.org/resource/Lenalidomide +
, http://dbpedia.org/resource/Immunofixation +
, http://dbpedia.org/resource/Non-Hodgkin_lymphoma +
, http://dbpedia.org/resource/Periodic_acid-Schiff_stain +
, http://dbpedia.org/resource/Mephalan +
|
| http://dbpedia.org/property/complications
|
Kidney failure,
|
| http://dbpedia.org/property/diagnosis
|
Kidney biopsy, serum protein electrophoresis with immunofixation, serum free light chain assay
|
| http://dbpedia.org/property/differential
|
http://dbpedia.org/resource/Multiple_myeloma +
, http://dbpedia.org/resource/Non-Hodgkin_lymphoma +
, http://dbpedia.org/resource/Chronic_lymphocytic_leukemia +
, http://dbpedia.org/resource/Waldenstrom%27s_macroglobulinemia +
|
| http://dbpedia.org/property/field
|
Nephrology, Pathology, Hematology
|
| http://dbpedia.org/property/name
|
Monoclonal gammopathy of renal significance
|
| http://dbpedia.org/property/risks
|
Presence of a monoclonal gammopathy, age greater than 50
|
| http://dbpedia.org/property/treatment
|
Clone directed therapy , immunomodulating medications , autologous stem cell transplantation, kidney transplantation,
|
| http://dbpedia.org/property/wikiPageUsesTemplate
|
http://dbpedia.org/resource/Template:Reflist +
, http://dbpedia.org/resource/Template:Infobox_medical_condition_%28new%29 +
, http://dbpedia.org/resource/Template:Distinguish +
, http://dbpedia.org/resource/Template:Technical +
|
| http://purl.org/dc/terms/subject
|
http://dbpedia.org/resource/Category:Kidney_diseases +
|
| http://www.w3.org/ns/prov#wasDerivedFrom
|
http://en.wikipedia.org/wiki/Monoclonal_gammopathy_of_renal_significance?oldid=1048560084&ns=0 +
|
| http://xmlns.com/foaf/0.1/isPrimaryTopicOf
|
http://en.wikipedia.org/wiki/Monoclonal_gammopathy_of_renal_significance +
|
| owl:differentFrom |
http://dbpedia.org/resource/Monoclonal_gammopathy +
|
| owl:sameAs |
http://dbpedia.org/resource/Monoclonal_gammopathy_of_renal_significance +
, https://global.dbpedia.org/id/3q2At +
, http://de.dbpedia.org/resource/Monoklonale_Gammopathie_renaler_Signifikanz +
, http://www.wikidata.org/entity/Q41333323 +
|
| rdfs:comment |
Monoclonal gammopathy of renal significanc … Monoclonal gammopathy of renal significance (MGRS) are a group of kidney disorders that present with kidney damage due to nephrotoxic monoclonal immunoglobulins (M proteins) secreted by clonal plasma cells or B cells. By definition, people with MGRS do not meet criteria for multiple myeloma or other hematologic malignancies. The term MGRS was introduced in 2012 by the International Kidney and Monoclonal Gammopathy Research Group (IKMG). MGRS is associated with monoclonal gammopathy of undetermined significance (MGUS). People with MGUS have a monoclonal gammopathy (presence of monoclonal immunoglobulins) but does not meet the criteria for the clonal burden nor the presence of end organ damage seen in hematologic malignancies. In a population based study based on the NHANES III health surveytudy based on the NHANES III health survey
, Die Monoklonale Gammopathie renaler Signif … Die Monoklonale Gammopathie renaler Signifikanz (MGRS) stellt eine symptomatische Monoklonale Gammopathie mit einer Nierenerkrankung dar, bei der die Kriterien für eine (per Definition) maligne Erkrankung wie dem Multiplen Myelom nicht erfüllt sind. Somit ist die MGRS eine Krankheits-Vorstufe, bei der in bestimmten Fällen auch eine hämatologisch-onkologische Therapie notwendig sein kann. Im weiteren Sinne können auch maligne Erkrankungen wie die AL-Amyloidose als MGRS kategorisiert werden.-Amyloidose als MGRS kategorisiert werden.
|
| rdfs:label |
Monoclonal gammopathy of renal significance
, Monoklonale Gammopathie renaler Signifikanz
|
