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lin-4是最早发现的microRNA，1993年发现于模式生物秀麗隱桿線蟲的基因组中，转录形成70碱基的前体后由Dicer酶切割形成21碱基的产物。
, In molecular biology lin-4 is a microRNA ( … In molecular biology lin-4 is a microRNA (miRNA) that was identified from a study of developmental timing in the nematode Caenorhabditis elegans. It was the first to be discovered of the miRNAs, a class of non-coding RNAs involved in gene regulation. miRNAs are transcribed as ~70 nucleotide precursors and subsequently processed by the Dicer enzyme to give a 21 nucleotide product. The extents of the hairpin precursors are not generally known and are estimated based on hairpin prediction. The products are thought to have regulatory roles through complete or partial complementarity to mRNA. The lin-4 gene has been found to lie within a 4.11kb intron of a separate host gene (see also [1]).on of a separate host gene (see also [1]).
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https://archive.today/20121223141415/http:/microrna.sanger.ac.uk/cgi-bin/sequences/mirna_entry.pl%3Facc=MI0000002 +
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Predicted secondary structure and sequence conservation of lin-4
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lin-4 microRNA precursor
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lin-4
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In molecular biology lin-4 is a microRNA ( … In molecular biology lin-4 is a microRNA (miRNA) that was identified from a study of developmental timing in the nematode Caenorhabditis elegans. It was the first to be discovered of the miRNAs, a class of non-coding RNAs involved in gene regulation. miRNAs are transcribed as ~70 nucleotide precursors and subsequently processed by the Dicer enzyme to give a 21 nucleotide product. The extents of the hairpin precursors are not generally known and are estimated based on hairpin prediction. The products are thought to have regulatory roles through complete or partial complementarity to mRNA. The lin-4 gene has been found to lie within a 4.11kb intron of a separate host gene (see also [1]).on of a separate host gene (see also [1]).
, lin-4是最早发现的microRNA，1993年发现于模式生物秀麗隱桿線蟲的基因组中，转录形成70碱基的前体后由Dicer酶切割形成21碱基的产物。
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Lin-4
, Lin-4 microRNA precursor
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