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Leukoencephalopathy with neuroaxonal spher … Leukoencephalopathy with neuroaxonal spheroids (LENAS) is an extremely rare kind of leukoencephalopathy and is classified as a neurodegenerative disease. LENAS is a cause of severe and subacute dementia that results from damage to certain areas of the brain. This damage is to a type of brain tissue called white matter and axon damage due to swellings which are termed spheroids. The rarity and unknown prevalence of this disease may be due to most symptoms being similar to other common disorders, leading to misdiagnosis. LENAS normally has an adult onset (but also can be present in childhood), which can present on MRIs that mimics progressive multiple sclerosis and is thus misdiagnosed for this instead. The genetic etiology of LENAS is known to follow an autosomal dominant pattern through a mutation in the CSF1R gene.tern through a mutation in the CSF1R gene.
, اعتلال بيضاء الدماغ مع الأجسام شبه الكروية … اعتلال بيضاء الدماغ مع الأجسام شبه الكروية المحورية هو نوع نادر من اعتلال بيضاء الدماغ ويصنف من أمراض التنكس العصبي. وهو سبب الخرف الحاد وتحت الحاد الذي ينتج عن تأذي مناطق معينة من الدماغ. تصاب المادة البيضاء والمحاور العصبية ويؤدي تورمها إلى تشكيل الأجسام شبه الكروية. تعزى ندرة هذا المرض وقلة انتشاره إلى تشابه أعراضه مع الكثير من الاضطرابات الشائعة ويؤدي ذلك إلى تشخيصه بشكل خاطئ. يصيب اعتلال بيضاء الدماغ البالغين بشكل شائع، وقد يبدأ في سن الطفولة، تظهر الإصابة على التصوير بالرنين المغناطيسي بشكل مماثل للتصلب المتعدد المترقي، ويشخص بشكل خاطئ على هذا الأساس. قد ينتج هذا المرض عن طفرة في جين CSF1R وينتقل بشكل وراثي سائد. طفرة في جين CSF1R وينتقل بشكل وراثي سائد.
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اعتلال بيضاء الدماغ مع الأجسام شبه الكروية … اعتلال بيضاء الدماغ مع الأجسام شبه الكروية المحورية هو نوع نادر من اعتلال بيضاء الدماغ ويصنف من أمراض التنكس العصبي. وهو سبب الخرف الحاد وتحت الحاد الذي ينتج عن تأذي مناطق معينة من الدماغ. تصاب المادة البيضاء والمحاور العصبية ويؤدي تورمها إلى تشكيل الأجسام شبه الكروية.يؤدي تورمها إلى تشكيل الأجسام شبه الكروية.
, Leukoencephalopathy with neuroaxonal spher … Leukoencephalopathy with neuroaxonal spheroids (LENAS) is an extremely rare kind of leukoencephalopathy and is classified as a neurodegenerative disease. LENAS is a cause of severe and subacute dementia that results from damage to certain areas of the brain. This damage is to a type of brain tissue called white matter and axon damage due to swellings which are termed spheroids. The genetic etiology of LENAS is known to follow an autosomal dominant pattern through a mutation in the CSF1R gene.tern through a mutation in the CSF1R gene.
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Leukoencephalopathy with neuroaxonal spheroids
, اعتلال بيضاء الدماغ مع الأجسام شبه الكروية المحورية
|
