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Laropiprant ist ein Arzneistoff aus der Gr … Laropiprant ist ein Arzneistoff aus der Gruppe der Prostaglandin-Antagonisten. In Kombination mit dem zur Behandlung von Fettstoffwechselstörungen verwendeten Lipidsenkers Nicotinsäure soll er nicotinsäurebedingte Nebenwirkungen des Flush-Syndroms (Erröten) reduzieren. Der Zulassungsinhaber stellte den Vertrieb der in ca. 70 Ländern (in Europa unter dem Markennamen Tredaptive) zugelassenen Nicotinsäure-Laropiprant-Kombination weltweit ein, nachdem Ende 2012 Daten aus der kardiovaskulären Endpunktstudie HPS2-THRIVE mit Tredaptive bekannt wurden.HPS2-THRIVE mit Tredaptive bekannt wurden.
, Laropiprant (INN) was a drug used in combi … Laropiprant (INN) was a drug used in combination with niacin to reduce blood cholesterol (LDL and VLDL) that is no longer sold, due to increases in side-effects with no cardiovascular benefit. Laropiprant itself has no cholesterol lowering effect, but it reduces facial flushes induced by niacin. Merck & Co. planned to market this combination under the trade names Cordaptive in the US and Tredaptive in Europe. Both brands contained 1000 mg of niacin and 20 mg of laropiprant in each tablet.n and 20 mg of laropiprant in each tablet.
, Laropiprant (DCI) ou laropiprante é um fár … Laropiprant (DCI) ou laropiprante é um fármaco que era utilizado em associação com a niacina no tratamento de dislipidemia e hipercolesterolemia primária. Não é mais comercializado devido aos efeitos colaterais cardiovasculares. O ácido nicotínico é um fármaco que diminui a produção hepática de VLDL, metabólito do LDL-c. Inibe também o transporte de colesterol do HDL-c para o VLDL. O efeito colateral mais notável do ácido nicotínico era o rubor causado pela ação da prostaglandina D. Esta associação com o laropiprant (antagonista da prostaglandina) reduziu este efeito colateral, sem alterar as propriedades do ácido nicotínico.terar as propriedades do ácido nicotínico.
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| rdfs:comment |
Laropiprant (INN) was a drug used in combi … Laropiprant (INN) was a drug used in combination with niacin to reduce blood cholesterol (LDL and VLDL) that is no longer sold, due to increases in side-effects with no cardiovascular benefit. Laropiprant itself has no cholesterol lowering effect, but it reduces facial flushes induced by niacin. Merck & Co. planned to market this combination under the trade names Cordaptive in the US and Tredaptive in Europe. Both brands contained 1000 mg of niacin and 20 mg of laropiprant in each tablet.n and 20 mg of laropiprant in each tablet.
, Laropiprant ist ein Arzneistoff aus der Gr … Laropiprant ist ein Arzneistoff aus der Gruppe der Prostaglandin-Antagonisten. In Kombination mit dem zur Behandlung von Fettstoffwechselstörungen verwendeten Lipidsenkers Nicotinsäure soll er nicotinsäurebedingte Nebenwirkungen des Flush-Syndroms (Erröten) reduzieren. Der Zulassungsinhaber stellte den Vertrieb der in ca. 70 Ländern (in Europa unter dem Markennamen Tredaptive) zugelassenen Nicotinsäure-Laropiprant-Kombination weltweit ein, nachdem Ende 2012 Daten aus der kardiovaskulären Endpunktstudie HPS2-THRIVE mit Tredaptive bekannt wurden.HPS2-THRIVE mit Tredaptive bekannt wurden.
, Laropiprant (DCI) ou laropiprante é um fármaco que era utilizado em associação com a niacina no tratamento de dislipidemia e hipercolesterolemia primária. Não é mais comercializado devido aos efeitos colaterais cardiovasculares.
|
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Laropiprante
, Laropiprant
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