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Żyłki o wysokim śródbłonku (ang. high endo … Żyłki o wysokim śródbłonku (ang. high endothelial venules, HEV) – naczynia krwionośne zlokalizowane na granicy stref: korowej i podkorowej węzła chłonnego, przez które do węzła wnikają limfocyty i umożliwiające ich recyrkulację. Charakterystyczny fenotyp tych naczyń umożliwiający ich funkcję wynika z oddziaływania produkowanej przez komórki dendrytyczne.a produkowanej przez komórki dendrytyczne.
, High endothelial venules (HEV) are special … High endothelial venules (HEV) are specialized post-capillary venous swellings characterized by plump endothelial cells as opposed to the usual thinner endothelial cells found in regular venules. HEVs enable lymphocytes circulating in the blood to directly enter a lymph node (by crossing through the HEV). In humans, HEVs are found in all secondary lymphoid organs (with the exception of spleen, where blood exits through open arterioles and enters the red pulp), including hundreds of lymph nodes dispersed in the body, tonsils and adenoids in the pharynx, Peyer's patches (PIs) in the small intestine, appendix, and small aggregates of lymphoid tissue in the stomach and large intestine. In contrast to the endothelial cells from other vessels, the high endothelial cells of HEVs have a distinctive appearance, consisting of a cuboidal morphology and with various receptors to interact with leukocytes (express specialized ligands for lymphocytes and are able to support high levels of lymphocyte extravasation). HEVs enable naïve lymphocytes to move in and out of the lymph nodes from the circulatory system. HEV cells express addressins, which are specific adhesion molecules that attach to the L-selectins on lymphocytes and anchor them to the HEV wall in preparation for crossing the endothelium. The endothelial cells of HEVs have a 'plump' appearance different from the flat morphology of endothelial cells that line other vessels, and are therefore called high endothelial cells by reference to their thickness. Another characteristic of HEVs, revealed by light-microscopic examination, is the presence of a large number of lymphocytes within their walls. This illustrates the function of HEVs in lymphocyte recruitment, and explains why these vessels were implicated in lymphocyte traffic from the time of their initial description.rom the time of their initial description.
, Les veinules à endothélium épais (ou veinu … Les veinules à endothélium épais (ou veinules postcapillaires à endothélium épais), que l'on trouve parfois sous l'appellation anglaise : High endothelial venules ou HEV, sont des vaisseaux permettant aux lymphocytes d'entrer dans les ganglions lymphatiques et dans certains autres organes lymphoïdes secondaires, à l'exception de la rate.
* Portail de la biologie
* Portail de la médecine
* Portail de l’anatomieil de la médecine
* Portail de l’anatomie
, Der Begriff hochendotheliale Venole (HEV) … Der Begriff hochendotheliale Venole (HEV) oder postkapilläre (epitheloide) Venole, oft auch englisch high endothelial venule, bezeichnet ein kleines venöses Blutgefäß, das in lymphatischen Organen (Lymphknoten, Peyersche Platten, Mandeln) direkt neben den Lymphfollikeln zu finden ist.kt neben den Lymphfollikeln zu finden ist.
, Le venule ad endotelio alto (HEV, high end … Le venule ad endotelio alto (HEV, high endothelial venules) sono specializzazioni di venule post-capillari caratterizzate dall'essere rivestite da cellule rigonfie del tipo cubico semplice in contrapposizione al normale endotelio delle venule. Le HEV permettono la migrazione dei linfociti dalla circolazione sanguigna agli organi linfoidi secondari e al timo. agli organi linfoidi secondari e al timo.
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| rdfs:comment |
High endothelial venules (HEV) are special … High endothelial venules (HEV) are specialized post-capillary venous swellings characterized by plump endothelial cells as opposed to the usual thinner endothelial cells found in regular venules. HEVs enable lymphocytes circulating in the blood to directly enter a lymph node (by crossing through the HEV). lymph node (by crossing through the HEV).
, Le venule ad endotelio alto (HEV, high end … Le venule ad endotelio alto (HEV, high endothelial venules) sono specializzazioni di venule post-capillari caratterizzate dall'essere rivestite da cellule rigonfie del tipo cubico semplice in contrapposizione al normale endotelio delle venule. Le HEV permettono la migrazione dei linfociti dalla circolazione sanguigna agli organi linfoidi secondari e al timo. agli organi linfoidi secondari e al timo.
, Żyłki o wysokim śródbłonku (ang. high endo … Żyłki o wysokim śródbłonku (ang. high endothelial venules, HEV) – naczynia krwionośne zlokalizowane na granicy stref: korowej i podkorowej węzła chłonnego, przez które do węzła wnikają limfocyty i umożliwiające ich recyrkulację. Charakterystyczny fenotyp tych naczyń umożliwiający ich funkcję wynika z oddziaływania produkowanej przez komórki dendrytyczne.a produkowanej przez komórki dendrytyczne.
, Les veinules à endothélium épais (ou veinu … Les veinules à endothélium épais (ou veinules postcapillaires à endothélium épais), que l'on trouve parfois sous l'appellation anglaise : High endothelial venules ou HEV, sont des vaisseaux permettant aux lymphocytes d'entrer dans les ganglions lymphatiques et dans certains autres organes lymphoïdes secondaires, à l'exception de la rate.
* Portail de la biologie
* Portail de la médecine
* Portail de l’anatomieil de la médecine
* Portail de l’anatomie
, Der Begriff hochendotheliale Venole (HEV) … Der Begriff hochendotheliale Venole (HEV) oder postkapilläre (epitheloide) Venole, oft auch englisch high endothelial venule, bezeichnet ein kleines venöses Blutgefäß, das in lymphatischen Organen (Lymphknoten, Peyersche Platten, Mandeln) direkt neben den Lymphfollikeln zu finden ist.kt neben den Lymphfollikeln zu finden ist.
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Veinule à endothélium épais
, High endothelial venules
, Venule ad endotelio alto
, Hochendotheliale Venole
, Żyłki o wysokim śródbłonku
|
