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The hepatitis delta virus (HDV) ribozyme i … The hepatitis delta virus (HDV) ribozyme is a non-coding RNA found in the hepatitis delta virus that is necessary for viral replication and is the only known human virus that utilizes ribozyme activity to infect its host. The ribozyme acts to process the RNA transcripts to unit lengths in a self-cleavage reaction during replication of the hepatitis delta virus, which is thought to propagate by a double rolling circle mechanism. The ribozyme is active in vivo in the absence of any protein factors and was the fastest known naturally occurring self-cleaving RNA at the time of its discovery. The crystal structure of this ribozyme has been solved using X-ray crystallography and shows five helical segments connected by a double pseudoknot. In addition to the sense (genomic version), all HDV viruses also have an antigenomic version of the HDV ribozyme. This version is not the exact complementary sequence but adopts the same structure as the sense (genomic) strand. The only "significant" differences between the two are a small bulge in P4 stem and a shorter J4/2 junction. Both the genomic and antigenomic ribozymes are necessary for replication.c ribozymes are necessary for replication.
, La ribozima del virus de hepatitis delta ( … La ribozima del virus de hepatitis delta (VHD) es una secuencia de ARN no codificante en el virus de hepatitis delta necesaria para la replicación viral y es el único ejemplo de un ARN catalítico asociado a un virus animal. La ribozima actúa procesando secuencias transcritas de ARN en unidades con el largo necesario en una reacción de autoescisión. La estructura del cristal de esta ribozima ha sido resuelta utilizando cristalografía de rayos X y muestra cinco segmentos conectados por un pseudonudo doble. La replicación del ADN viral produce multímeros lineales de ARN genómico y antigenómico, los cuales también poseen la actividad de autoescisión. La versión antigenómica no es una secuencia complementaria exacta, pero adopta la misma estructura que la hebra genómica. La única diferencia significativa entre las dos es un pequeño abultamiento en el tallo P4 y una unión J4/2 más corta. La estructura de la ribozima del virus de hepatitis delta está estructuralmente y bioquímicamente relacionada con la ribozima mamífera CPEB3. Secuencias no relacionadas con alta similitud a la ribozima VHD han evolucionado mediante evolución convergente en algunos retrotransposones (por ejemplo, en el elemento de ARN R2 en insectos y en el L1Tc y probablemente otros retrotransposones en tripanosomátidos).etrotransposones en tripanosomátidos).
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Predicted secondary structure and sequence conservation of HDV ribozyme
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Hepatitis delta virus ribozyme
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La ribozima del virus de hepatitis delta ( … La ribozima del virus de hepatitis delta (VHD) es una secuencia de ARN no codificante en el virus de hepatitis delta necesaria para la replicación viral y es el único ejemplo de un ARN catalítico asociado a un virus animal. La ribozima actúa procesando secuencias transcritas de ARN en unidades con el largo necesario en una reacción de autoescisión. La estructura del cristal de esta ribozima ha sido resuelta utilizando cristalografía de rayos X y muestra cinco segmentos conectados por un pseudonudo doble.entos conectados por un pseudonudo doble.
, The hepatitis delta virus (HDV) ribozyme i … The hepatitis delta virus (HDV) ribozyme is a non-coding RNA found in the hepatitis delta virus that is necessary for viral replication and is the only known human virus that utilizes ribozyme activity to infect its host. The ribozyme acts to process the RNA transcripts to unit lengths in a self-cleavage reaction during replication of the hepatitis delta virus, which is thought to propagate by a double rolling circle mechanism. The ribozyme is active in vivo in the absence of any protein factors and was the fastest known naturally occurring self-cleaving RNA at the time of its discovery.cleaving RNA at the time of its discovery.
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Ribozima del virus de hepatitis delta
, Hepatitis delta virus ribozyme
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