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Un ribozyme en tête de marteau (hammerhead … Un ribozyme en tête de marteau (hammerhead ribozyme en anglais) est un segment d'ARN qui catalyse le clivage et la jonction réversibles d'un site spécifique sur une molécule d'ARN. Ces ribozymes sont utilisés comme modèles pour la recherche sur les structures et les propriétés de l'ARN ainsi que dans les expériences de clivage ciblé de l'ARN, certaines en vue d'applications thérapeutiques. Ils tirent leur nom de la ressemblance des premières représentations de leur structure secondaire avec le requin marteau. Ils ont d'abord été identifiés parmi des ARN satellites et des viroïdes puis se sont révélés être très largement distribués à travers de nombreuses formes de vie. Les réactions d'auto-clivage, publiées pour la première fois en 1986, font partie d'un mécanisme de réplication circulaire. La séquence de ces ribozymes est suffisante pour l'auto-clivage et agit en formant une structure tertiaire tridimensionnelle conservée.ure tertiaire tridimensionnelle conservée.
, El ribozim hammerhead o cap de martell és … El ribozim hammerhead o cap de martell és un tipus d'àcid ribonucleic que s'autocatalitza (es talla a si mateix) mitjançant un petit motiu d'estructura secundària conservada que s'anomena cap de martell per la seva forma. La majoria de ARNs hammerhead són subconjunts de dues classes d'ARN patogènic vegetal: els ARN satèl·lit dels RNA vírics i dels viroides. Les reaccions autocatalítiques, les quals foren descrites per primer cop el 1986, són part d'un mecanisme de replicació cíclica. La seqüència del hammerhead és suficient per a l'autocatalització i actua formant una estructura terciària tridimensional conservada.ctura terciària tridimensional conservada.
, Рибозимы типа hammerhead — это малые самор … Рибозимы типа hammerhead — это малые саморазрезающие РНК, которые имеют консервативную последовательность и обнаружены у некоторых вироидов и ассоциированы с сателлитными РНК некоторых вирусов растений. Впервые рибозимы типа hammerhead были открыты у вириоидов растений, такие рибозимы катализировали сиквенс-специфичное разрезание в молекулах РНК благодаря специфической третичной структуре. Вторичная структура напоминает головку молотка — англ. hammerhead.минает головку молотка — англ. hammerhead.
, The hammerhead ribozyme is an RNA motif th … The hammerhead ribozyme is an RNA motif that catalyzes reversible cleavage and ligation reactions at a specific site within an RNA molecule. It is one of several catalytic RNAs (ribozymes) known to occur in nature. It serves as a model system for research on the structure and properties of RNA, and is used for targeted RNA cleavage experiments, some with proposed therapeutic applications. Named for the resemblance of early secondary structure diagrams to a hammerhead shark, hammerhead ribozymes were originally discovered in two classes of plant virus-like RNAs: satellite RNAs and viroids. They are also known in some classes of retrotransposons, including the retrozymes. The hammerhead ribozyme motif has been ubiquitously reported in lineages across the tree of life. The self-cleavage reactions, first reported in 1986, are part of a rolling circle replication mechanism. The hammerhead sequence is sufficient for self-cleavage and acts by forming a conserved three-dimensional tertiary structure.rved three-dimensional tertiary structure.
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Predicted secondary structure and sequence conservation of the HH9 ribozyme found conserved from lizard to human genomes
, Predicted secondary structure and sequence conservation of Hammerhead ribozyme
, Predicted secondary structure and sequence conservation of Hammerhead_1
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The hammerhead ribozyme is an RNA motif th … The hammerhead ribozyme is an RNA motif that catalyzes reversible cleavage and ligation reactions at a specific site within an RNA molecule. It is one of several catalytic RNAs (ribozymes) known to occur in nature. It serves as a model system for research on the structure and properties of RNA, and is used for targeted RNA cleavage experiments, some with proposed therapeutic applications. Named for the resemblance of early secondary structure diagrams to a hammerhead shark, hammerhead ribozymes were originally discovered in two classes of plant virus-like RNAs: satellite RNAs and viroids. They are also known in some classes of retrotransposons, including the retrozymes. The hammerhead ribozyme motif has been ubiquitously reported in lineages across the tree of life.orted in lineages across the tree of life.
, Рибозимы типа hammerhead — это малые самор … Рибозимы типа hammerhead — это малые саморазрезающие РНК, которые имеют консервативную последовательность и обнаружены у некоторых вироидов и ассоциированы с сателлитными РНК некоторых вирусов растений. Впервые рибозимы типа hammerhead были открыты у вириоидов растений, такие рибозимы катализировали сиквенс-специфичное разрезание в молекулах РНК благодаря специфической третичной структуре. Вторичная структура напоминает головку молотка — англ. hammerhead.минает головку молотка — англ. hammerhead.
, Un ribozyme en tête de marteau (hammerhead … Un ribozyme en tête de marteau (hammerhead ribozyme en anglais) est un segment d'ARN qui catalyse le clivage et la jonction réversibles d'un site spécifique sur une molécule d'ARN. Ces ribozymes sont utilisés comme modèles pour la recherche sur les structures et les propriétés de l'ARN ainsi que dans les expériences de clivage ciblé de l'ARN, certaines en vue d'applications thérapeutiques. Ils tirent leur nom de la ressemblance des premières représentations de leur structure secondaire avec le requin marteau. Ils ont d'abord été identifiés parmi des ARN satellites et des viroïdes puis se sont révélés être très largement distribués à travers de nombreuses formes de vie.ués à travers de nombreuses formes de vie.
, El ribozim hammerhead o cap de martell és … El ribozim hammerhead o cap de martell és un tipus d'àcid ribonucleic que s'autocatalitza (es talla a si mateix) mitjançant un petit motiu d'estructura secundària conservada que s'anomena cap de martell per la seva forma. La majoria de ARNs hammerhead són subconjunts de dues classes d'ARN patogènic vegetal: els ARN satèl·lit dels RNA vírics i dels viroides. Les reaccions autocatalítiques, les quals foren descrites per primer cop el 1986, són part d'un mecanisme de replicació cíclica. La seqüència del hammerhead és suficient per a l'autocatalització i actua formant una estructura terciària tridimensional conservada.ctura terciària tridimensional conservada.
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Hammerhead ribozyme
, Ribozyme en tête de marteau
, Рибозим типа hammerhead
, Ribozim cap de martell
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