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In molecular biology, the HORMA domain (na … In molecular biology, the HORMA domain (named after the Hop1p, Rev7p and MAD2 proteins) is a protein domain that has been suggested to recognise chromatin states resulting from DNA adducts, double stranded breaks or non-attachment to the spindle and act as an adaptor that recruits other proteins. Hop1 is a meiosis-specific protein, Rev7 is required for DNA damage induced mutagenesis, and MAD2 is a spindle checkpoint protein which prevents progression of the cell cycle upon detection of a defect in mitotic spindle integrity. of a defect in mitotic spindle integrity.
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HORMA
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2041
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crystal structure of mad1-mad2 reveals a conserved mad2 binding motif in mad1 and cdc20.
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IPR003511
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HORMA domain
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PF02301
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1
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HORMA
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| rdfs:comment |
In molecular biology, the HORMA domain (na … In molecular biology, the HORMA domain (named after the Hop1p, Rev7p and MAD2 proteins) is a protein domain that has been suggested to recognise chromatin states resulting from DNA adducts, double stranded breaks or non-attachment to the spindle and act as an adaptor that recruits other proteins. Hop1 is a meiosis-specific protein, Rev7 is required for DNA damage induced mutagenesis, and MAD2 is a spindle checkpoint protein which prevents progression of the cell cycle upon detection of a defect in mitotic spindle integrity. of a defect in mitotic spindle integrity.
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HORMA domain
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