| http://dbpedia.org/ontology/abstract
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The Lariat capping ribozyme (formerly call … The Lariat capping ribozyme (formerly called GIR1 branching ribozyme) is a ~180 nt ribozyme with an apparent resemblance to a group I ribozyme.It is found within a complex type of group I introns also termed twin-ribozyme introns.Rather than splicing, it catalyses a branching reaction in which the 2'OH of an internal residue is involved in a nucleophilic attack at a nearby phosphodiester bond.As a result, the RNA is cleaved at an internal processing site (IPS), leaving a 3'OH and a downstream product with a 3 nt lariat at its 5' end. The lariat has the first and the third nucleotide joined by a 2',5' phosphodiester bond and is referred to as 'the lariat cap' because it caps an intron-encoded mRNA. The resulting lariat cap seems to contribute by increasing the half-life of the HE mRNA, thus conferring an evolutionary advantage to the HE.rring an evolutionary advantage to the HE.
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http://commons.wikimedia.org/wiki/Special:FilePath/WikiDiGIR-rDNA.png?width=300 +
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https://archive.today/20130223001701/http:/www2.uit.no/ikbViewer/page/ansatte/organisasjon/hjem%3Fp_dimension_id=92436&p_menu=42374&p_lang=2 +
, http://www-ibmc.u-strasbg.fr/arn/Westhof/index.html +
, https://web.archive.org/web/20090806020436/http:/icmm.ku.dk/Forskergrupper/rna/research_projects/ +
, https://web.archive.org/web/20081028204053/http:/www.pulasthi.info/2007/08/not-all-enzymatic-reactions-are.html +
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21252747
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10653
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1058649975
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http://dbpedia.org/resource/Didymium_iridis +
, http://dbpedia.org/resource/File:WikiDiGIR-rDNA.png +
, http://dbpedia.org/resource/Ribosomal_DNA +
, http://dbpedia.org/resource/Category:RNA_splicing +
, http://dbpedia.org/resource/Group_I_catalytic_intron +
, http://dbpedia.org/resource/Category:Ribozymes +
, http://dbpedia.org/resource/Biocatalysis +
, http://dbpedia.org/resource/Reduction_%28chemistry%29 +
, http://dbpedia.org/resource/MRNA +
, http://dbpedia.org/resource/Group_I_intron +
, http://dbpedia.org/resource/Secondary_structure +
, http://dbpedia.org/resource/Naegleria +
, http://dbpedia.org/resource/Evolution +
, http://dbpedia.org/resource/5%27 +
, http://dbpedia.org/resource/Homing_endonuclease +
, http://dbpedia.org/resource/Ribozyme +
, http://dbpedia.org/resource/Eric_Westhof +
, http://dbpedia.org/resource/Nucleophilic_attack +
, http://dbpedia.org/resource/Half-life +
, http://dbpedia.org/resource/Hydroxyl +
, http://dbpedia.org/resource/RNA_splicing +
, http://dbpedia.org/resource/Ribonuclease_P +
, http://dbpedia.org/resource/Nucleotide +
, http://dbpedia.org/resource/Residue_%28chemistry%29 +
, http://dbpedia.org/resource/In_vitro +
, http://dbpedia.org/resource/Phosphodiester_bond +
, http://dbpedia.org/resource/Protist +
, http://dbpedia.org/resource/Transesterification +
, http://dbpedia.org/resource/Intron +
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| http://dbpedia.org/property/caption
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Conserved secondary structure of GIR1
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| http://dbpedia.org/property/id
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RF01807
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| http://dbpedia.org/property/name
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GIR1 branching ribozyme
, GIR1 Branching Ribozyme
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| http://dbpedia.org/property/rfam
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RF01807
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| http://dbpedia.org/property/rnaType
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Intron
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| http://dbpedia.org/property/symbol
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GIR1
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Naegleria
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http://dbpedia.org/resource/Category:Ribozymes +
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| rdfs:comment |
The Lariat capping ribozyme (formerly call … The Lariat capping ribozyme (formerly called GIR1 branching ribozyme) is a ~180 nt ribozyme with an apparent resemblance to a group I ribozyme.It is found within a complex type of group I introns also termed twin-ribozyme introns.Rather than splicing, it catalyses a branching reaction in which the 2'OH of an internal residue is involved in a nucleophilic attack at a nearby phosphodiester bond.As a result, the RNA is cleaved at an internal processing site (IPS), leaving a 3'OH and a downstream product with a 3 nt lariat at its 5' end. The lariat has the first and the third nucleotide joined by a 2',5' phosphodiester bond and is referred to as 'the lariat cap' because it caps an intron-encoded mRNA. The resulting lariat cap seems to contribute by increasing the half-life of the HE mRNA, thusreasing the half-life of the HE mRNA, thus
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| rdfs:label |
GIR1 branching ribozyme
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