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eIF-2 is a kinase enzyme that phosphorylat … eIF-2 is a kinase enzyme that phosphorylates eIF-2. There are four forms in mammals:
* EIF2AK1: heme-regulated inhibitor kinase (HRI)
* EIF2AK2: the double-stranded RNA-dependent kinase (PKR)
* EIF2AK3: PEK/PERK
* EIF2AK4: GCN2 These are all responsible for the phosphorylation of the alpha subunit of eIF-2 at serine 51, one of the best-characterized mechanisms for down-regulating protein synthesis in eukaryotes in response to various cellular stress response's.nse to various cellular stress response's.
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| rdfs:comment |
eIF-2 is a kinase enzyme that phosphorylat … eIF-2 is a kinase enzyme that phosphorylates eIF-2. There are four forms in mammals:
* EIF2AK1: heme-regulated inhibitor kinase (HRI)
* EIF2AK2: the double-stranded RNA-dependent kinase (PKR)
* EIF2AK3: PEK/PERK
* EIF2AK4: GCN2 These are all responsible for the phosphorylation of the alpha subunit of eIF-2 at serine 51, one of the best-characterized mechanisms for down-regulating protein synthesis in eukaryotes in response to various cellular stress response's.nse to various cellular stress response's.
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| rdfs:label |
EIF-2 kinase
|
