| http://dbpedia.org/ontology/abstract
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Cytochrome P450 aromatic O-demethylase is … Cytochrome P450 aromatic O-demethylase is a bacterial enzyme that catalyzes the demethylation of lignin and various lignols. The net reaction follows the following stoichiometry, illustrated with a generic methoxy arene: ArOCH3 + O2 + 2 e− + 2 H+ → ArOH + CH2O + H2O The enzyme is notable for its promiscuity, it effects the O-demethylation of a range of substrates, including lignin. It is a heterodimeric protein derived from the products of two genes. The component proteins are a cytochrome P450 enzyme (encoded by the gcoA gene from the family CYP255A) and a three-domain reductase (encoded by the gcoB gene) complexed with three cofactors (2Fe-2S, FAD, and NADH).h three cofactors (2Fe-2S, FAD, and NADH).
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63122178
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8513
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1110745557
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| http://dbpedia.org/ontology/wikiPageWikiLink
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http://dbpedia.org/resource/Guaiacol +
, http://dbpedia.org/resource/Category:EC_1.14.14 +
, http://dbpedia.org/resource/NAD%2B +
, http://dbpedia.org/resource/Oxygen_rebound_mechanism +
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, http://dbpedia.org/resource/Category:EC_1.6.2 +
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, http://dbpedia.org/resource/Monolignol +
, http://dbpedia.org/resource/Heme +
, http://dbpedia.org/resource/FAD +
, http://dbpedia.org/resource/Oxidoreductase +
, http://dbpedia.org/resource/Cofactor_%28biochemistry%29 +
, http://dbpedia.org/resource/NADH +
, http://dbpedia.org/resource/Heterodimeric +
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| http://dbpedia.org/property/caption
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Crystal structure of gcoA in complex with heme and guaiacol based on .
, Crystal structure of gcoB complexed with FAD and an iron–sulfur cluster based on .
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| http://dbpedia.org/property/ecnumber
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1.14
, 1.6
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| http://dbpedia.org/property/name
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Aromatic O-demethylase, reductase subunit
, Aromatic O-demethylase, cytochrome P450 subunit
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| http://dbpedia.org/property/organism
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Amycolatopsis sp.
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| http://dbpedia.org/property/pdb
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5
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| http://dbpedia.org/property/symbol
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gcoB
, gcoA
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| http://dbpedia.org/property/taxid
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385957
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P0DPQ7
, P0DPQ8
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http://dbpedia.org/resource/Category:Prokaryote_genes +
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http://en.wikipedia.org/wiki/Cytochrome_P450_aromatic_O-demethylase?oldid=1110745557&ns=0 +
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| rdfs:comment |
Cytochrome P450 aromatic O-demethylase is … Cytochrome P450 aromatic O-demethylase is a bacterial enzyme that catalyzes the demethylation of lignin and various lignols. The net reaction follows the following stoichiometry, illustrated with a generic methoxy arene: ArOCH3 + O2 + 2 e− + 2 H+ → ArOH + CH2O + H2O The enzyme is notable for its promiscuity, it effects the O-demethylation of a range of substrates, including lignin.f a range of substrates, including lignin.
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| rdfs:label |
Cytochrome P450 aromatic O-demethylase
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