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Cromakalim (INN) is a potassium channel-op … Cromakalim (INN) is a potassium channel-opening vasodilator. The active isomer is levcromakalim. It acts on ATP-sensitive potassium channels and so causes membrane hyperpolarization. It can be used to treat hypertension as it will relax vascular smooth muscle to lower blood pressure. Hyperpolarisation of smooth muscle cell membranes pulls their membrane potential away from the threshold, so making it more difficult to excite them and thereby cause relaxation. excite them and thereby cause relaxation.
, クロマカリム(Cromakalim)は、カリウムチャネルを開放する血管拡張薬である。活性型異性体は、レブクロマカリムである。ATP感受性カリウムチャネルに作用するため、膜のの原因となる。血管の平滑筋を拡張して血圧を下げるため、高血圧の治療に用いられる。平滑筋細胞膜の過分極は、膜の電位を閾値から引き下げるため、励起して収縮させることを困難にする。
, Il cromakalim è un farmaco antiipertensivo appartenente alla classe farmacologica degli attivatori del canale del potassio e alla classe chimica dei .
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, Structural formula of cromakalim
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| rdfs:comment |
Cromakalim (INN) is a potassium channel-op … Cromakalim (INN) is a potassium channel-opening vasodilator. The active isomer is levcromakalim. It acts on ATP-sensitive potassium channels and so causes membrane hyperpolarization. It can be used to treat hypertension as it will relax vascular smooth muscle to lower blood pressure. Hyperpolarisation of smooth muscle cell membranes pulls their membrane potential away from the threshold, so making it more difficult to excite them and thereby cause relaxation. excite them and thereby cause relaxation.
, クロマカリム(Cromakalim)は、カリウムチャネルを開放する血管拡張薬である。活性型異性体は、レブクロマカリムである。ATP感受性カリウムチャネルに作用するため、膜のの原因となる。血管の平滑筋を拡張して血圧を下げるため、高血圧の治療に用いられる。平滑筋細胞膜の過分極は、膜の電位を閾値から引き下げるため、励起して収縮させることを困難にする。
, Il cromakalim è un farmaco antiipertensivo appartenente alla classe farmacologica degli attivatori del canale del potassio e alla classe chimica dei .
|
| rdfs:label |
Cromakalim
, クロマカリム
|
