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Calcium concentration microdomains (CCMs) … Calcium concentration microdomains (CCMs) are sites in a cell's cytoplasm with a localised high calcium ion (Ca2+) concentration. They are found immediately around the intracellular opening of calcium channels; when a calcium channel opens, the Ca2+ concentration in the adjacent CCM increases up to several hundred micromolar (μM). These microdomains take part in calcium signaling, which has a diverse range of potential outcomes. Calcium concentration microdomains can be visualised with fluorescence microscopy by using aequorin as a reporter protein.y by using aequorin as a reporter protein.
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Calcium concentration microdomains (CCMs) … Calcium concentration microdomains (CCMs) are sites in a cell's cytoplasm with a localised high calcium ion (Ca2+) concentration. They are found immediately around the intracellular opening of calcium channels; when a calcium channel opens, the Ca2+ concentration in the adjacent CCM increases up to several hundred micromolar (μM). These microdomains take part in calcium signaling, which has a diverse range of potential outcomes. Calcium concentration microdomains can be visualised with fluorescence microscopy by using aequorin as a reporter protein.y by using aequorin as a reporter protein.
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Calcium concentration microdomains
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