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Inhibitoren im Calcitonin-Gene-Related-Pep … Inhibitoren im Calcitonin-Gene-Related-Peptide-Signalweg sind Wirkstoffe, welche die Wirkung des Calcitonin Gene-Related Peptide (CGRP) hemmen. Sie heben die blutgefäßerweiternden Eigenschaften des CGRP auf. Ihr Einsatz in der Akuttherapie oder Prophylaxe der Migräne basiert auf der Beobachtung, dass das Neuropeptid CGRP eine wichtige Rolle an der während einer Migräneattacke pathologischen Erweiterung der meningealen Blutgefäße spielt. Diese Erkenntnis führte zur Entwicklung zweier Wirkstoffgruppen: Antikörper, die gegen das CGRP oder gegen den CGRP-Rezeptor wirken und die niedermolekularen CGRP-Rezeptorantagonisten.edermolekularen CGRP-Rezeptorantagonisten.
, Calcitonin gene-related peptide (CGRP) rec … Calcitonin gene-related peptide (CGRP) receptor antagonists are a class of drugs that act as antagonists of the calcitonin gene-related peptide receptor (CGRPR). Several monoclonal antibodies which binds to the CGRP receptor or peptide have been approved for prevention of migraine. Three small molecule CGRPR antagonists are approved in the U.S. as antimigraine agents. Drugs of this class have also been investigated for use in osteoarthritis.en investigated for use in osteoarthritis.
, ضادات مستقبل الببتيد المرتبط بجين الكالسيت … ضادات مستقبل الببتيد المرتبط بجين الكالسيتونين (بالإنجليزية: CGRP receptor antagonists أو Calcitonin gene-related peptide receptor antagonists) هي مجموعة من الأدوية الضادة لمستقبلات الببتيد المرتبط بجين الكالسيتونين. من أمثلة هذه المجموعة:
* أولسيجيبانت
* تلكاجيبانت
* . وتجرى التجارب السريرية على هذه الأدوية لاحتمال فعاليتها في علاج الصداع النصفي.ية لاحتمال فعاليتها في علاج الصداع النصفي.
, Gli antagonisti del recettore del peptide correlato al gene della calcitonina sono una classe di farmaci che inibiscono il recettore del peptide correlato al gene della calcitonina (CGRP).
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Inhibitoren im Calcitonin-Gene-Related-Peptide-Signalweg sind Wirkstoffe, welche die Wirkung des Calcitonin Gene-Related Peptide (CGRP) hemmen. Sie heben die blutgefäßerweiternden Eigenschaften des CGRP auf.
, Calcitonin gene-related peptide (CGRP) rec … Calcitonin gene-related peptide (CGRP) receptor antagonists are a class of drugs that act as antagonists of the calcitonin gene-related peptide receptor (CGRPR). Several monoclonal antibodies which binds to the CGRP receptor or peptide have been approved for prevention of migraine. Three small molecule CGRPR antagonists are approved in the U.S. as antimigraine agents. Drugs of this class have also been investigated for use in osteoarthritis.en investigated for use in osteoarthritis.
, ضادات مستقبل الببتيد المرتبط بجين الكالسيت … ضادات مستقبل الببتيد المرتبط بجين الكالسيتونين (بالإنجليزية: CGRP receptor antagonists أو Calcitonin gene-related peptide receptor antagonists) هي مجموعة من الأدوية الضادة لمستقبلات الببتيد المرتبط بجين الكالسيتونين. من أمثلة هذه المجموعة:
* أولسيجيبانت
* تلكاجيبانت
* . وتجرى التجارب السريرية على هذه الأدوية لاحتمال فعاليتها في علاج الصداع النصفي.ية لاحتمال فعاليتها في علاج الصداع النصفي.
, Gli antagonisti del recettore del peptide correlato al gene della calcitonina sono una classe di farmaci che inibiscono il recettore del peptide correlato al gene della calcitonina (CGRP).
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| rdfs:label |
Antagonisti del recettore del peptide correlato al gene della calcitonina
, ضاد مستقبل الببتيد المرتبط بجين الكالسيتونين
, Inhibitoren im Calcitonin-Gene-Related-Peptide-Signalweg
, CGRP-hämmare
, Calcitonin gene-related peptide receptor antagonist
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