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Buccal tablets are a type of solid dosage … Buccal tablets are a type of solid dosage form administered orally in between the gums and the inner linings of the cheek. These tablets, held within the buccal pouch, either act on the oral mucosa or are rapidly absorbed through the buccal mucosal membrane. Since drugs "absorbed through the buccal mucosa bypass gastrointestinal enzymatic degradation and hepatic first-pass effect", prescribing buccal tablets is increasingly common among healthcare professionals. Buccal tablets serve as an alternative drug delivery in patients where compliance is a known issue, including those who are unconscious, nauseous, or having difficulty in swallowing (i.e. dysphagia). A wide variety of these drugs are available on the market to be prescribed in hospitals and other healthcare settings, including common examples like Corlan®, Fentora®, and Buccastem®. The most common route for drug transport through the buccal mucosa is the paracellular pathway. Most hydrophilic drugs permeate the cheek linings via the paracellular pathway through the mechanism of passive diffusion, and hydrophobic drugs are transported through the transcellular pathway. This route of administration is beneficial for mucosal administration and transmucosal administration. Buccal tablets are typically formulated through the direct compression of drug, powder mixture, swollen polymer, and other agents that assist in processing. Buccal tablets offer many advantages in terms of accessibility, ease of administration and withdrawal, and hence may improve patient compliance. Notable drawbacks of buccal tablets include the hazard of choking by involuntarily swallowing the tablet and irritation of the gums. Caution should be exercised along with counselling from medical practitioners before use of these tablets.practitioners before use of these tablets.
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| rdfs:comment |
Buccal tablets are a type of solid dosage … Buccal tablets are a type of solid dosage form administered orally in between the gums and the inner linings of the cheek. These tablets, held within the buccal pouch, either act on the oral mucosa or are rapidly absorbed through the buccal mucosal membrane. Since drugs "absorbed through the buccal mucosa bypass gastrointestinal enzymatic degradation and hepatic first-pass effect", prescribing buccal tablets is increasingly common among healthcare professionals.gly common among healthcare professionals.
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Buccal tablet
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