| http://dbpedia.org/ontology/abstract
|
Alphabodies, also known as Cell-Penetratin … Alphabodies, also known as Cell-Penetrating Alphabodies or CPAB for short, are small 10 kDa proteins engineered to bind to a variety of antigens. Despite their name, they are not structurally similar to antibodies, which makes them a type of antibody mimetic. Alphabodies are different from many other antibody mimetics in their ability to reach and bind to intracellular protein targets. Their single chain alpha-helical structure is designed by computer modelling, inspired by naturally existing coiled-coil protein structures. Alphabodies are being developed by the Belgian biotechnology company Complix N.V. as potential new pharmaceutical drugs against cancer and autoimmune disease. In 2012, a collaboration agreement was signed with Monsanto to develop the technology for agricultural applications as well.ogy for agricultural applications as well.
|
| http://dbpedia.org/ontology/thumbnail
|
http://commons.wikimedia.org/wiki/Special:FilePath/Alphabody1.png?width=300 +
|
| http://dbpedia.org/ontology/wikiPageExternalLink
|
http://www.complix.com/ +
, http://www.rcsb.org/pdb/explore/explore.do%3FstructureId=4OG9 +
|
| http://dbpedia.org/ontology/wikiPageID
|
46234477
|
| http://dbpedia.org/ontology/wikiPageLength
|
10933
|
| http://dbpedia.org/ontology/wikiPageRevisionID
|
951695047
|
| http://dbpedia.org/ontology/wikiPageWikiLink
|
http://dbpedia.org/resource/Receptor_antagonist +
, http://dbpedia.org/resource/Affinity_maturation +
, http://dbpedia.org/resource/Agriculture +
, http://dbpedia.org/resource/Crohn%27s_disease +
, http://dbpedia.org/resource/Antibody_mimetic +
, http://dbpedia.org/resource/Category:Antibody_mimetics +
, http://dbpedia.org/resource/Protein_structure +
, http://dbpedia.org/resource/Gimv +
, http://dbpedia.org/resource/Autoimmune_disease +
, http://dbpedia.org/resource/Private_equity +
, http://dbpedia.org/resource/Ghent_University +
, http://dbpedia.org/resource/Gene_expression +
, http://dbpedia.org/resource/Interleukin_12 +
, http://dbpedia.org/resource/Antibodies +
, http://dbpedia.org/resource/Concentration +
, http://dbpedia.org/resource/Monobody +
, http://dbpedia.org/resource/Peptide +
, http://dbpedia.org/resource/Glycine +
, http://dbpedia.org/resource/Proteins +
, http://dbpedia.org/resource/Pharmaceutical_drug +
, http://dbpedia.org/resource/Belgium +
, http://dbpedia.org/resource/Shareholders +
, http://dbpedia.org/resource/File:AlphabodyCD.jpg +
, http://dbpedia.org/resource/Biotech_Fund_Flanders +
, http://dbpedia.org/resource/File:AlphabodyDN.jpg +
, http://dbpedia.org/resource/Binding_selectivity +
, http://dbpedia.org/resource/File:Alphabody1.png +
, http://dbpedia.org/resource/Ligand_%28biochemistry%29 +
, http://dbpedia.org/resource/File:AlphabodyXRC.jpg +
, http://dbpedia.org/resource/Interleukin_12_subunit_beta +
, http://dbpedia.org/resource/Psoriasis +
, http://dbpedia.org/resource/Interleukin_23 +
, http://dbpedia.org/resource/Collaboration +
, http://dbpedia.org/resource/Intracellular +
, http://dbpedia.org/resource/Circular_dichroism +
, http://dbpedia.org/resource/Affitin +
, http://dbpedia.org/resource/Cost-effectiveness_analysis +
, http://dbpedia.org/resource/Amino_acid_residues +
, http://dbpedia.org/resource/Denaturation_%28biochemistry%29 +
, http://dbpedia.org/resource/Non-covalent_interactions +
, http://dbpedia.org/resource/Antigens +
, http://dbpedia.org/resource/Isoleucine +
, http://dbpedia.org/resource/Alanine +
, http://dbpedia.org/resource/Cancer +
, http://dbpedia.org/resource/Inflammation +
, http://dbpedia.org/resource/Rheumatoid_arthritis +
, http://dbpedia.org/resource/Thermostability +
, http://dbpedia.org/resource/DARPin +
, http://dbpedia.org/resource/Biotechnology +
, http://dbpedia.org/resource/Alpha-helix +
, http://dbpedia.org/resource/Cytokine +
, http://dbpedia.org/resource/Anticalin +
, http://dbpedia.org/resource/Serine +
, http://dbpedia.org/resource/Affimer +
, http://dbpedia.org/resource/X-ray_crystallography +
, http://dbpedia.org/resource/Small_molecule +
, http://dbpedia.org/resource/Coiled-coil +
, http://dbpedia.org/resource/Protein_trimer +
, http://dbpedia.org/resource/Apoptosis +
, http://dbpedia.org/resource/Monsanto +
, http://dbpedia.org/resource/Side-effects +
, http://dbpedia.org/resource/Affibody_molecule +
, http://dbpedia.org/resource/Phage_display +
|
| http://dbpedia.org/property/wikiPageUsesTemplate
|
http://dbpedia.org/resource/Template:Reflist +
, http://dbpedia.org/resource/Template:Further +
, http://dbpedia.org/resource/Template:Engineered_antibodies +
|
| http://purl.org/dc/terms/subject
|
http://dbpedia.org/resource/Category:Antibody_mimetics +
|
| http://purl.org/linguistics/gold/hypernym
|
http://dbpedia.org/resource/Proteins +
|
| http://www.w3.org/ns/prov#wasDerivedFrom
|
http://en.wikipedia.org/wiki/Alphabody?oldid=951695047&ns=0 +
|
| http://xmlns.com/foaf/0.1/depiction
|
http://commons.wikimedia.org/wiki/Special:FilePath/Alphabody1.png +
, http://commons.wikimedia.org/wiki/Special:FilePath/AlphabodyCD.jpg +
, http://commons.wikimedia.org/wiki/Special:FilePath/AlphabodyDN.jpg +
, http://commons.wikimedia.org/wiki/Special:FilePath/AlphabodyXRC.jpg +
|
| http://xmlns.com/foaf/0.1/isPrimaryTopicOf
|
http://en.wikipedia.org/wiki/Alphabody +
|
| owl:sameAs |
https://global.dbpedia.org/id/uPZA +
, http://www.wikidata.org/entity/Q19903259 +
, http://dbpedia.org/resource/Alphabody +
, http://rdf.freebase.com/ns/m.01311lg5 +
|
| rdf:type |
http://dbpedia.org/ontology/Protein +
|
| rdfs:comment |
Alphabodies, also known as Cell-Penetratin … Alphabodies, also known as Cell-Penetrating Alphabodies or CPAB for short, are small 10 kDa proteins engineered to bind to a variety of antigens. Despite their name, they are not structurally similar to antibodies, which makes them a type of antibody mimetic. Alphabodies are different from many other antibody mimetics in their ability to reach and bind to intracellular protein targets. Their single chain alpha-helical structure is designed by computer modelling, inspired by naturally existing coiled-coil protein structures. Alphabodies are being developed by the Belgian biotechnology company Complix N.V. as potential new pharmaceutical drugs against cancer and autoimmune disease. In 2012, a collaboration agreement was signed with Monsanto to develop the technology for agricultural applicatp the technology for agricultural applicat
|
| rdfs:label |
Alphabody
|
