| http://dbpedia.org/ontology/abstract
|
AM-411 (part of the AM cannabinoid series) … AM-411 (part of the AM cannabinoid series) is an analgesic drug that is a cannabinoid agonist. It is a derivative of Δ8-THC substituted with an adamantyl group at the 3-position, demonstrating that the binding pocket for the alkyl chain at this position can accommodate significant bulk. AM-411 is a potent and fairly selective CB1 full agonist with a Ki of 6.80 nM, but is still also a moderately potent CB2 agonist with a Ki of 52.0 nM. It produces similar effects to other cannabinoid agonists such as analgesia, sedation, and anxiolysis.ch as analgesia, sedation, and anxiolysis.
|
| http://dbpedia.org/ontology/casNumber
|
212835-02-4
|
| http://dbpedia.org/ontology/chEMBL
|
434351
|
| http://dbpedia.org/ontology/fdaUniiCode
|
2K9WS7SUR3
|
| http://dbpedia.org/ontology/pubchem
|
9799945
|
| http://dbpedia.org/ontology/thumbnail
|
http://commons.wikimedia.org/wiki/Special:FilePath/AM-411_Structure.svg?width=300 +
|
| http://dbpedia.org/ontology/wikiPageID
|
17257897
|
| http://dbpedia.org/ontology/wikiPageLength
|
3370
|
| http://dbpedia.org/ontology/wikiPageRevisionID
|
1088094619
|
| http://dbpedia.org/ontology/wikiPageWikiLink
|
http://dbpedia.org/resource/Category:Adamantanes +
, http://dbpedia.org/resource/Agonist +
, http://dbpedia.org/resource/Sedation +
, http://dbpedia.org/resource/Category:Benzochromenes +
, http://dbpedia.org/resource/Cannabinoid +
, http://dbpedia.org/resource/List_of_AM_cannabinoids +
, http://dbpedia.org/resource/Category:AM_cannabinoids +
, http://dbpedia.org/resource/AM-087 +
, http://dbpedia.org/resource/THC +
, http://dbpedia.org/resource/KM-233 +
, http://dbpedia.org/resource/Adamantane +
, http://dbpedia.org/resource/AM-1248 +
, http://dbpedia.org/resource/Dissociation_constant +
, http://dbpedia.org/resource/Category:Phenols +
, http://dbpedia.org/resource/Analgesia +
, http://dbpedia.org/resource/Anxiolytic +
, http://dbpedia.org/resource/Analgesic +
, http://dbpedia.org/resource/Alkyl +
|
| http://dbpedia.org/property/c
|
26
|
| http://dbpedia.org/property/casNumber
|
212835
|
| http://dbpedia.org/property/chembl
|
434351
|
| http://dbpedia.org/property/chemspiderid
|
7975710
|
| http://dbpedia.org/property/h
|
34
|
| http://dbpedia.org/property/iupacName
|
-3
|
| http://dbpedia.org/property/o
|
2
|
| http://dbpedia.org/property/pubchem
|
9799945
|
| http://dbpedia.org/property/smiles
|
C5C6CC4CC5cccc1C2CC=CCC2C3C
|
| http://dbpedia.org/property/stdinchi
|
1
|
| http://dbpedia.org/property/stdinchikey
|
RPBMPWGKZFLMFN-OKFSJJLXSA-N
|
| http://dbpedia.org/property/unii
|
2
|
| http://dbpedia.org/property/verifiedrevid
|
415995491
|
| http://dbpedia.org/property/width
|
240
|
| http://dbpedia.org/property/wikiPageUsesTemplate
|
http://dbpedia.org/resource/Template:Cascite +
, http://dbpedia.org/resource/Template:Reflist +
, http://dbpedia.org/resource/Template:Chemspidercite +
, http://dbpedia.org/resource/Template:Cannabinoid-stub +
, http://dbpedia.org/resource/Template:Cannabinoids +
, http://dbpedia.org/resource/Template:Ebicite +
, http://dbpedia.org/resource/Template:Stdinchicite +
, http://dbpedia.org/resource/Template:Drugbox +
, http://dbpedia.org/resource/Template:Fdacite +
, http://dbpedia.org/resource/Template:Short_description +
|
| http://purl.org/dc/terms/subject
|
http://dbpedia.org/resource/Category:Benzochromenes +
, http://dbpedia.org/resource/Category:Phenols +
, http://dbpedia.org/resource/Category:Adamantanes +
, http://dbpedia.org/resource/Category:AM_cannabinoids +
|
| http://purl.org/linguistics/gold/hypernym
|
http://dbpedia.org/resource/Drug +
|
| http://www.w3.org/ns/prov#wasDerivedFrom
|
http://en.wikipedia.org/wiki/AM-411?oldid=1088094619&ns=0 +
|
| http://xmlns.com/foaf/0.1/depiction
|
http://commons.wikimedia.org/wiki/Special:FilePath/AM-411_Structure.svg +
|
| http://xmlns.com/foaf/0.1/isPrimaryTopicOf
|
http://en.wikipedia.org/wiki/AM-411 +
|
| owl:sameAs |
https://global.dbpedia.org/id/MB66 +
, http://sh.dbpedia.org/resource/AM-411 +
, http://www.wikidata.org/entity/Q13424933 +
, http://rdf.freebase.com/ns/m.043rwx0 +
, http://yago-knowledge.org/resource/AM-411 +
, http://sr.dbpedia.org/resource/AM-411 +
, http://dbpedia.org/resource/AM-411 +
|
| rdf:type |
http://dbpedia.org/class/yago/Chemical114806838 +
, http://dbpedia.org/class/yago/Substance100019613 +
, http://www.ontologydesignpatterns.org/ont/dul/DUL.owl#ChemicalObject +
, http://dbpedia.org/class/yago/Relation100031921 +
, http://dbpedia.org/class/yago/Part113809207 +
, http://www.wikidata.org/entity/Q8386 +
, http://dbpedia.org/ontology/Drug +
, http://dbpedia.org/ontology/ChemicalSubstance +
, http://dbpedia.org/class/yago/PhysicalEntity100001930 +
, http://dbpedia.org/class/yago/WikicatPhenols +
, http://dbpedia.org/class/yago/Phenol114989545 +
, http://umbel.org/umbel/rc/DrugProduct +
, http://dbpedia.org/class/yago/Abstraction100002137 +
, http://dbpedia.org/class/yago/Matter100020827 +
, http://dbpedia.org/class/yago/OrganicCompound114727670 +
, http://dbpedia.org/class/yago/Material114580897 +
, http://dbpedia.org/class/yago/Compound114818238 +
|
| rdfs:comment |
AM-411 (part of the AM cannabinoid series) … AM-411 (part of the AM cannabinoid series) is an analgesic drug that is a cannabinoid agonist. It is a derivative of Δ8-THC substituted with an adamantyl group at the 3-position, demonstrating that the binding pocket for the alkyl chain at this position can accommodate significant bulk. AM-411 is a potent and fairly selective CB1 full agonist with a Ki of 6.80 nM, but is still also a moderately potent CB2 agonist with a Ki of 52.0 nM. It produces similar effects to other cannabinoid agonists such as analgesia, sedation, and anxiolysis.ch as analgesia, sedation, and anxiolysis.
|
| rdfs:label |
AM-411
|
