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8-フェニルテオフィリン(8-Phenyltheophylline)または8-フェニ … 8-フェニルテオフィリン(8-Phenyltheophylline)または8-フェニル-1,3-ジメチルキサンチン(8-Phenyl-1,3-dimethylxanthine)は、キサンチン系の薬品であり、及びの強い選択的アンタゴニストとして作用するが、他のキサンチン誘導体と異なり、ホスホジエステラーゼ阻害活性は持たない。動物に対しては、カフェインと同程度の強さの覚醒作用を持つ。また、8-フェニルテオフィリンは肝臓の酵素であるCYP1A2を強く選択的に阻害する効果も見られ、通常はCYP1A2によって代謝される他の薬品とも相互作用する。阻害する効果も見られ、通常はCYP1A2によって代謝される他の薬品とも相互作用する。
, 8-Fenilteofilina (8-fenil-1,3-dimetilxanti … 8-Fenilteofilina (8-fenil-1,3-dimetilxantina, 8-PT) é uma droga derivada da família da xantina a qual atua como um potente e para os receptores de adenosina A1 e , mas diferentemente de outros derivados de xantina não tem virtualmente atividade como um inibidor da fosfodiesterase. Tem efeitos estimulantes em animais com potencial similar a cafeína.m animais com potencial similar a cafeína.
, 8-Phenyltheophylline (8-phenyl-1,3-dimethy … 8-Phenyltheophylline (8-phenyl-1,3-dimethylxanthine, 8-PT) is a drug derived from the xanthine family which acts as a potent and selective antagonist for the adenosine receptors A1 and A2A, but unlike other xanthine derivatives has virtually no activity as a phosphodiesterase inhibitor. It has stimulant effects in animals with similar potency to caffeine. Coincidentally 8-phenyltheophylline has also been found to be a potent and selective inhibitor of the liver enzyme CYP1A2 which makes it likely to cause interactions with other drugs which are normally metabolised by CYP1A2. which are normally metabolised by CYP1A2.
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Ball-and-stick model of the 8-phenyltheophylline molecule
, Skeletal formula of 8-phenyltheophylline
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| rdfs:comment |
8-Fenilteofilina (8-fenil-1,3-dimetilxanti … 8-Fenilteofilina (8-fenil-1,3-dimetilxantina, 8-PT) é uma droga derivada da família da xantina a qual atua como um potente e para os receptores de adenosina A1 e , mas diferentemente de outros derivados de xantina não tem virtualmente atividade como um inibidor da fosfodiesterase. Tem efeitos estimulantes em animais com potencial similar a cafeína.m animais com potencial similar a cafeína.
, 8-フェニルテオフィリン(8-Phenyltheophylline)または8-フェニ … 8-フェニルテオフィリン(8-Phenyltheophylline)または8-フェニル-1,3-ジメチルキサンチン(8-Phenyl-1,3-dimethylxanthine)は、キサンチン系の薬品であり、及びの強い選択的アンタゴニストとして作用するが、他のキサンチン誘導体と異なり、ホスホジエステラーゼ阻害活性は持たない。動物に対しては、カフェインと同程度の強さの覚醒作用を持つ。また、8-フェニルテオフィリンは肝臓の酵素であるCYP1A2を強く選択的に阻害する効果も見られ、通常はCYP1A2によって代謝される他の薬品とも相互作用する。阻害する効果も見られ、通常はCYP1A2によって代謝される他の薬品とも相互作用する。
, 8-Phenyltheophylline (8-phenyl-1,3-dimethy … 8-Phenyltheophylline (8-phenyl-1,3-dimethylxanthine, 8-PT) is a drug derived from the xanthine family which acts as a potent and selective antagonist for the adenosine receptors A1 and A2A, but unlike other xanthine derivatives has virtually no activity as a phosphodiesterase inhibitor. It has stimulant effects in animals with similar potency to caffeine. Coincidentally 8-phenyltheophylline has also been found to be a potent and selective inhibitor of the liver enzyme CYP1A2 which makes it likely to cause interactions with other drugs which are normally metabolised by CYP1A2. which are normally metabolised by CYP1A2.
|
| rdfs:label |
8-Phenyltheophylline
, 8-フェニルテオフィリン
, 8-Fenilteofilina
|
