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3-O-Methyldopa (3-OMD) is one of the most … 3-O-Methyldopa (3-OMD) is one of the most important metabolites of L-DOPA, a drug used in the treatment of the Parkinson's disease. 3-O-methyldopa is produced by the methylation of L-DOPA by the enzyme catechol-O-methyltransferase. The necessary cofactor for this enzymatic reaction is s-adenosyl methionine (SAM). Its half-life (approximately 15 hours) is longer than L-DOPA's half-life, which is about one hour. This means that it is accumulated in the plasma and the brain of chronic L-DOPA therapy patients such as people suffering from Parkinson's disease. 3-OMD is often elevated in the plasma and cerebrospinal fluid of Parkinson's disease patients taking L-DOPA.arkinson's disease patients taking L-DOPA.
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3-Methoxytyrosine; 3-Methoxydopa; (L)-3-O-Methyl-DOPA; 3-Methoxy-(L)-tyrosine; (L)-4-Hydroxy-3-methoxyphenylalanine; (L)-3-Methoxytyrosine; (L)-3-Methoxy-4-hydroxyphenylalanine
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2-Amino-3-(4-hydroxy-3-methoxyphenyl)propanoic acid
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| rdfs:comment |
3-O-Methyldopa (3-OMD) is one of the most … 3-O-Methyldopa (3-OMD) is one of the most important metabolites of L-DOPA, a drug used in the treatment of the Parkinson's disease. 3-O-methyldopa is produced by the methylation of L-DOPA by the enzyme catechol-O-methyltransferase. The necessary cofactor for this enzymatic reaction is s-adenosyl methionine (SAM). Its half-life (approximately 15 hours) is longer than L-DOPA's half-life, which is about one hour. This means that it is accumulated in the plasma and the brain of chronic L-DOPA therapy patients such as people suffering from Parkinson's disease.people suffering from Parkinson's disease.
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3-O-Methyldopa
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